Predictive factors of response to anti-CGRP pathway drugs in people with multiple sclerosis [0.03%]
预测抗CGRP通路药物对多发性硬化患者反应的影响因素
Viviana Nociti,Simone Cesarano,Marina Romozzi et al.
Viviana Nociti et al.
Background: Migraine is common in people with multiple sclerosis (PwMS) and substantially contributes to disability and impaired quality of life. Although (CGRP)-targeting therapies have reshaped migraine prevention, evid...
Trigeminovascular calcitonin gene-related peptide release and peripheral vascular responses in a mouse model of accelerated aging: Implications for migraine [0.03%]
加速衰老小鼠模型中的三叉血管降钙素基因相关肽释放及外周血管反应：对偏头痛的意义
Linda Al-Hassany,Eloisa Rubio-Beltrán,Alejandro Labastida-Ramirez et al.
Linda Al-Hassany et al.
Objective: Understanding age-related changes in migraine is pivotal, considering the increasing global life expectancy. In addition, both aging and migraine are prominent cardiovascular risk factors. It remains unclear wh...
Adam S Sprouse Blum,Richard Watts,Scott G Hipko et al.
Adam S Sprouse Blum et al.
Background and objectives: Prior studies assessing cerebrovascular reactivity (CVR) in participants with migraine primarily utilized Doppler ultrasonography and focused on large vascular territories due to limitations of ...
Observational Study
The journal of headache and pain. 2026 Jul 3;27(1):168. DOI:10.1186/s10194-026-02432-w 2026
Profile of migraine patients in Middle East and North Africa (MENA) region: a multi-center study [0.03%]
一项多中心研究：中东和北非地区偏头痛患者的特征
Mona Hussein,Jasem Al-Hashel,Derya Uludüz et al.
Mona Hussein et al.
Background: The Middle East and North Africa (MENA) region presents a unique demographic, cultural, and socioeconomic profile that influence migraine burden and management. Comprehensive multicenter data on patient charac...
CXCL10 knockdown attenuates vestibular migraine in rats by inhibiting PI3K-mediated neuroinflammation and central sensitization [0.03%]
CXCL10敲低通过抑制PI3K介导的神经炎症和中枢敏化来缓解实验性前庭型偏头痛
Mao-Mei Song,Gianluca Coppola,Ying-Jie Gao et al.
Mao-Mei Song et al.
Background: Vestibular migraine (VM) is characterized by recurrent episodes of headache and vertigo, and its pathogenesis is closely associated with neuroinflammation and central sensitization. C-X-C motif chemokine ligan...
Is migraine a spectrum disorder? Questioning the concept of "episodic" and "chronic" migraine using population-based data from 10,226 adults with migraine from 14 countries [0.03%]
偏头痛是谱系疾病吗？利用来自14个国家的10,226名成年偏头痛患者的基于人口的数据质疑“发作性”和“慢性”偏头痛的概念
Andreas Kattem Husøy,Timothy J Steiner
Andreas Kattem Husøy
Background: The first edition of the International Classification of Headache Disorders (ICHD-I) did not recognize chronic migraine (CM). ICHD-II introduced CM as a complication of migraine, with criteria that were widely...
Prelimbic cortex layer 5 GABAergic neurons mediate chronic pain and memory impairment by regulating excitatory/inhibitory imbalance [0.03%]
前扣带回皮层第5层GABA能神经元通过调节兴奋/抑制失衡介导慢性疼痛和记忆障碍
Xiaoling Wang,Zhongyuan Lu,Tian Mao et al.
Xiaoling Wang et al.
Background: Chronic pain can cause both hyperalgesia and cognitive impairment symptoms and involves long-term alterations in the neural circuits, leading to abnormal cortical activity. GABAergic signaling are particularly...
Dissecting the shared genetic architecture between migraine subtypes and cardiovascular diseases: a multi-layered genomic analysis [0.03%]
migraine亚型与心血管疾病之间的共享遗传结构的多层基因组分析
Yiming Liu,You Ma,Yiwei Liu
Yiming Liu
Background: Epidemiological studies have linked migraine to an increased risk of cardiovascular disease (CVD); however, the shared genetic basis and putative causal relationships between migraine subtypes and cardiovascul...
Headache among children and adolescents in Zambia: revised prevalence estimates, and estimates of attributed burden, from a national schools-based study [0.03%]
赞比亚中小学生头痛患病率的修订估计及其归因负担的估算
Nfwama Kawatu,Somwe Wa Somwe,Ornella Ciccone et al.
Nfwama Kawatu et al.
Background: In our earlier report of headache prevalence among children (6-11 years) and adolescents (12-17) in Zambia, we defined undifferentiated headache (UdH) conventionally as mild headache lasting < 1 h. However, we...
Gnao1 acts as a gatekeeper to alleviate neuropathic pain by silencing pro-nociceptive signaling cascades [0.03%]
Gnao1通过沉默促痛信号通路充当缓解神经病理性疼痛的守门者
Jieyi Cai,Hui Li,Lü Chen et al.
Jieyi Cai et al.
Background: Neuropathic pain is a debilitating condition with limited effective treatments, highlighting an urgent need for non-opioid analgesic targets. Gαo, encoded by the Gnao1 gene, is an abundant G protein in the ne...