Migraine triggers and lifestyle modifications: an assessment of patients' awareness and the role of healthcare providers in patient education [0.03%]
头痛诱发因素及生活方式的调整：患者认知状况及医务工作者宣传教育作用的评估
Alaa Elmazny,Rehab Magdy,Mona Hussein et al.
Alaa Elmazny et al.
Background and objectives: Lifestyle modifications and coping with migraine triggers have a crucial role in migraine management. This study aimed to assess the knowledge of patients with migraine about triggers, managing ...
Exploring the epigenetic modifications of the RONS-TRPA1-CGRP axis in migraine pathophysiology [0.03%]
探究RONS-TRPA1-CGRP轴表观遗传改变在偏头痛发病机制中的作用
Michal Fila,Elzbieta Pawlowska,Jan Krekora et al.
Michal Fila et al.
Background: Epigenetic studies in migraine provided results on the occurrence or lack of epigenetic modifications of genes whose products are important in migraine pathogenesis. However, these studies focus on single gene...
A nomogram for the prediction of response to anti-CGRP mAbs: the CGRP score [0.03%]
一种预测反CGRP-mAb反应的评分卡：CGRP评分
Marina Romozzi,Ammar Lokhandwala,Catello Vollono et al.
Marina Romozzi et al.
Introduction: Real-world studies have explored potential predictors of response to anti-calcitonin gene related peptide (CGRP) monoclonal antibodies (mAbs), though results have remained inconsistent. Machine learning (ML)...
State-of-the-art preclinical techniques to study the impact of spreading depolarizations in awake rodents [0.03%]
清醒啮齿动物中用于研究扩散去极化影响的最新前期技术
Alejandro Labastida-Ramirez,Neela K Codadu,Kagan Agan et al.
Alejandro Labastida-Ramirez et al.
Background: Understanding the mechanisms of pathological brain network activity and the efficacy of therapies requires testing hypothesis in vivo, where brain circuitry remains preserved. Therefore, animal models are a ke...
Oral atogepant mitigates spreading depolarization-induced pain and anxiety behavior in mice [0.03%]
口服atogepant可缓解小鼠由皮层扩散去极化引起的疼痛和焦虑行为
Melih Z Kaya,Pradeep Banerjee,Cenk Ayata et al.
Melih Z Kaya et al.
Background: Spreading depolarization (SD) is the most likely cause of migraine aura and may be linked to trigeminal nociception. Using minimally invasive optogenetic SD induction (opto-SD), we previously showed that SD tr...
The epidemiology, management, and the associated burden of migraine in Australian primary care: a retrospective analysis of electronic health record data [0.03%]
澳大利亚初级保健中偏头痛的流行病学、管理及相关负担：电子健康记录数据的回顾性分析
Nicole Limberg,Jason C Ray,Benjamin Harvey et al.
Nicole Limberg et al.
Background: Migraine accounts for more disability than all other neurologic conditions combined. Despite this, more than 40% of people with migraine do not seek medical care. Migraine is associated with a higher risk of c...
Unveiling migraine subtype heterogeneity and risk loci: integrated genome-wide association study and single-cell transcriptomics discovery [0.03%]
解开偏头痛亚型异质性及风险位点：全基因组关联研究和单细胞转录组学发现的综合分析
Shuxu Wei,Yan Quan,Xinyi Li et al.
Shuxu Wei et al.
Background: Migraine, a debilitating neurological disorder with distinct subtypes (migraine with aura [MA] and migraine without aura [MO]), exhibits genetic and spatial heterogeneity that remains poorly understood. While ...
Longitudinal assessment of migraine burden in resistant and refractory migraine - Data from the prospective REFINE study [0.03%]
难治性和顽固性偏头痛负担的纵向评估——前瞻性REFINE研究的数据分析
Umberto Pensato,Raffaele Ornello,Chiara Rosignoli et al.
Umberto Pensato et al.
Background: Some individuals with migraine fail to respond adequately to preventive treatments, bearing most of migraine burden. The European Headache Federation (EHF) classifies these individuals into resistant migraine ...
Substrate-selective COX-2 inhibition by IMMA attenuates posttraumatic headache via endocannabinoid modulation and neuroinflammatory suppression [0.03%]
选择性作用于底物的环氧化酶-2抑制剂IMMA可通过内源大麻素调节和神经炎症抑制减轻创伤后头痛
Jie Wen,Mikiei Tanaka,Yumin Zhang
Jie Wen
Background: Posttraumatic headache (PTH) is a common and debilitating consequence of traumatic brain injury (TBI), characterized by neuroinflammation and pain hypersensitivity. Current treatments are limited, and novel th...
Neural signature of chronic migraine mice model and related photophobia in the primary visual cortex [0.03%]
慢性偏头痛小鼠模型在初级视觉皮层中的神经特征及相关光敏感性研究
Kai-Bo Zhang,Cheng Peng,Zhen Liu et al.
Kai-Bo Zhang et al.
Background: Migraine episodes are known to induce heightened photosensitivity. Neuroimaging investigations have revealed that the primary visual cortex exhibits abnormal activation patterns both during and between migrain...