Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis [0.03%]
通过神经炎症和血管生成缓解慢性压迫损伤引起的疼痛敏化
Hao-Jung Cheng,Nan-Fu Chen,Wu-Fu Chen et al.
Hao-Jung Cheng et al.
Background: Neuropathic pain involves neuroinflammation and upregulation of glycolysis in the central nervous system. Unfortunately, few effective treatments are available for managing this type of pain. The overactivatio...
Disrupted topologic efficiency of white matter structural connectome in migraine: a graph-based connectomics study [0.03%]
基于图论的连接组学研究发现偏头痛患者的结构连接组拓扑效率异常
Yanliang Mei,Dong Qiu,Zhonghua Xiong et al.
Yanliang Mei et al.
Objective: To delineate the structural connectome alterations in patients with chronic migraine (CM), episodic migraine (EM), and healthy controls (HCs). ...
Plasma pQTL and brain eQTL integration identifies PNKP as a therapeutic target and reveals mechanistic insights into migraine pathophysiology [0.03%]
整合血浆pQTL和大脑eQTL识别PNKP为治疗靶点并揭示偏头痛发病机制的见解
Jiafei Lou,Miaoqian Tu,Maosheng Xu et al.
Jiafei Lou et al.
Background: Migraine is a prevalent neurological disorder affecting 14.1% of the global population. Despite advances in genetic research, further investigation is needed to identify therapeutic targets and better understa...
Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headache [0.03%]
独特的表达谱揭示了三叉神经系统的胶质细胞参与创伤后头痛形成的作用
Gurueswar Nagarajan,Yumin Zhang
Gurueswar Nagarajan
Background: Post-traumatic headache (PTH) is a common comorbid symptom affecting at least one-third of patients with mild traumatic brain injury (mTBI). While neuroinflammation is known to contribute to the development of...
The PopHEAD study: a population-based, cross-sectional study on headache burden in Norway: methods and validation of questionnaire-based diagnoses [0.03%]
挪威头痛负担的流行病学调查：方法及基于问卷诊断的有效性研究
Maria Bengtson Argren,Helene Engstrand,Andreas Kattem Husøy et al.
Maria Bengtson Argren et al.
Background: There is a lack of up-to-date information on the prevalence and burden of headache in Norway. Here we describe the methods and validation of the diagnostic tool of the PopHEAD study, a study designed to determ...
Formoterol dynamically alters endocannabinoid tone in the periaqueductal gray inducing headache [0.03%]
_formoterol动态改变periaqueductal灰质中的内源性大麻素张力以诱导头痛_
Ingrid L Peterson,Erika Liktor-Busa,Kelly L Karlage et al.
Ingrid L Peterson et al.
Background: Headache is a pain disorder present in populations world-wide with a higher incidence in females. Specifically, the incidences of medication overuse headache (MOH) have increased worldwide. Comorbidities of MO...
The prevalence of headache disorders among medical students in Vietnam: a cross-sectional study [0.03%]
越南医学生头痛患病率：一项横断面研究
Hieu Trung Vo,Khoi Hong Vo,Lam Tung Duong et al.
Hieu Trung Vo et al.
Background: Headache disorders are among the leading causes of disability worldwide, especially in young adults. However, no data on the burden of these disorders in Vietnam have been published to date. This study is the ...
Serum microRNA qPCR profiling and validation indicate upregulation of circulating miR-145-5p and miR-26a-5p in migraineurs [0.03%]
血清microRNA的qPCR检测和验证表明偏头痛患者循环miR-145-5p和miR-26a-5p上调
Joanna Kordacka,Renata Gruszka,Magdalena Zakrzewska
Joanna Kordacka
Background: In recent years, miRNAs found in biological fluids have gained interest as biomarkers of numerous conditions, including migraine. This study aimed to identify differences in the levels of circulating miRNAs in...
Attentional network deficits in patients with migraine: behavioral and electrophysiological evidence [0.03%]
偏头痛患者的注意力网络缺陷：行为和电生理学证据
Yuxin Chen,Siyuan Xie,Libo Zhang et al.
Yuxin Chen et al.
Background: Patients with migraine often experience not only headache pain but also cognitive dysfunction, particularly in attention, which is frequently overlooked in both diagnosis and treatment. The influence of these ...
Regulatory T cells require peripheral CCL2-CCR2 signaling to facilitate the resolution of medication overuse headache-related behavioral sensitization [0.03%]
调节性T细胞需要外周CCL2-CCR2信号传导来促进药物过度使用性头痛相关的行为敏感化的解决过程
Sun Ryu,Jintao Zhang,Roli Simoes et al.
Sun Ryu et al.
Background: Medication overuse headache (MOH) is the most common secondary headache disorder, resulting from chronic and excessive use of medication to treat headaches, for example, sumatriptan. In a recent study, we have...