Efficacy and continuability of 675 mg fremanezumab administration over 2 years [0.03%]
弗雷马珠单抗675毫克治疗两年的有效性和可延续性
Shohei Yoshida,Noboru Imai,Masato Keicho et al.
Shohei Yoshida et al.
Background: Real-world data on the long-term adherence to- and efficacy of fremanezumab 675 mg quarterly dosing remain scarce. Our study evaluated the efficacy of- and patient adherence to 675 mg fremanezumab for episodic...
Observational Study
The journal of headache and pain. 2025 Mar 11;26(1):51. DOI:10.1186/s10194-025-01994-5 2025
Offset analgesia as a marker of dysfunctional pain modulation in episodic and chronic migraine [0.03%]
偏头痛和慢性偏头痛中异常疼痛调节的标志之offset镇痛效应
Giuseppe Cosentino,Elisa Antoniazzi,Camilla Cavigioli et al.
Giuseppe Cosentino et al.
Background: The offset analgesia phenomenon refers to the disproportionately large decrease in the perceived pain following a slight decrease in intensity of a noxious heat stimulus. It is considered an expression of the ...
The burden of migraine and tension-type headache in Asia from 1990 to 2021 [0.03%]
1990年至2021年亚洲地区偏头痛和紧张型头痛的疾病负担分析
Yingzhu Zhao,Yujie Yi,Hong Zhou et al.
Yingzhu Zhao et al.
Background: In recent years, headache diseases have spread throughout the world, causing great suffering and even severe disability to patients, and increasing the burden on health care systems. However, studies of specif...
The efficacy and safety of zavegepant nasal inhalation versus oral calcitonin-gene related peptide receptor antagonists in the acute treatment of migraine: a systematic review and network meta-analysis of the literature [0.03%]
扎珠肽鼻吸剂与口服降钙素基因相关肽受体拮抗剂在偏头痛急性治疗中的有效性和安全性：文献的系统评价和网络荟萃分析
Zixiang Zhu,Yanbing Tang,Longyuan Li et al.
Zixiang Zhu et al.
Background: The latest randomized controlled trial (RCT) revealed that zavegepant, a new nasal inhalation calcitonin gene-related peptide (CGRP) receptor antagonist, has a clear efficacy in the acute treatment of migraine...
Exploring vestibulocerebellum-vestibular nuclei-spinal trigeminal nucleus causals communication and TRPV2 ion channel in a mouse model of vestibular migraine [0.03%]
前庭小脑-前庭核-脊髓三叉神经核因果通讯及TRPV2离子通道在鼠源性前庭偏头痛模型中的探索研究
Qingling Zhai,Qihui Chen,Ning Zhang et al.
Qingling Zhai et al.
Background: Vestibular migraine (VM) is a disorder characterized by recurrent episodes of dizziness or vertigo and is often accompanied by headache. The mechanisms underlying vestibular dysfunction and pain in VM remain u...
Burden of hidden migraine among the Arab general population: a cross-sectional study [0.03%]
阿拉伯普通人群中隐藏性偏头痛的疾病负担：一项横断面研究
Mohamed A Elzayat,Shorouq A Kassab,Mona A F Nada et al.
Mohamed A Elzayat et al.
Background: Migraine is a common type of primary headache which is responsible for one-third of the headache cases. It's also considered the third highest neurological disease with disability in 2021, however, underdiagno...
Advances in GLP-1 receptor agonists for pain treatment and their future potential [0.03%]
GLP-1受体激动剂在疼痛治疗中的进展及其未来潜力
Yongtao He,Biao Xu,Mengna Zhang et al.
Yongtao He et al.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) show substantial efficacy in regulating blood glucose levels and lipid metabolism, initially as an effective treatment for diabetes mellitus. In recent years, GLP-1RAs have become a focal...
Network meta-analysis comparing efficacy of different strategies on medication-overuse headache [0.03%]
网络荟萃分析比较不同策略在药物过量性头痛疗效中的效果
Prut Koonalintip,Suppakorn Yamutai,Suwanna Setthawatcharawanich et al.
Prut Koonalintip et al.
Background: Medication-overuse headache (MOH) is the most common secondary headache disorder, resulting from or leading to the frequent use of acute headache medications. Despite the availability of various treatment stra...
Optogenetic cortical spreading depression originating from the primary visual cortex induces migraine-like pain and anxiety behaviors in freely moving C57BL/6 J mice [0.03%]
光遗传学源自视觉皮层的皮质扩散抑竭可诱导自由活动C57BL/6 J小鼠产生类似偏头痛和焦虑的行为
Huijuan Yuan,Weinan Na,Bozhi Li et al.
Huijuan Yuan et al.
Background: Migraine is the second disabling neurological disorder with a high prevalence. Aura occurs in one-third of migraineurs and visual aura accounts for over 90%. Cortical spreading depression (CSD) underlies aura ...
Pregnenolone sulfate potentiates tetrodotoxin-resistant Na+ channels to increase the excitability of dural afferent neurons in rats [0.03%]
硫酸孕烯醇酮通过加强河豚毒素抗性钠离子通道来增加大鼠脑膜传入神经元的兴奋性
Il-Sung Jang,Michiko Nakamura
Il-Sung Jang
Background: Although peripheral administration of pregnenolone sulfate (PS) has been reported to produce pronociceptive effects, the mechanisms by which PS modulates the excitability of nociceptive neurons are poorly unde...