Stefania Ferraro,Greta Demichelis,Jean Paul Medina Carrion et al.
Stefania Ferraro et al.
Background: This study aimed to identify mesocorticolimbic functional abnormalities in cluster headache (CH) patients, disentangling the roles of chronification and affective symptoms. ...
GIANT: a prospective, multicenter, real-world study on the effectiveness, safety, and tolerability of atogepant in migraine patients with multiple therapeutic failures [0.03%]
千帆研究：一项真实世界、多中心前瞻性研究，评估既往治疗失败的 migrain人群使用Atogepant的有效性、安全性和耐受性
Piero Barbanti,Gabriella Egeo,Francesca Pistoia et al.
Piero Barbanti et al.
Background: Atogepant, the first oral CGRP receptor antagonist approved for migraine prevention, has demonstrated efficacy and safety in randomized clinical trials (RCT). However, prospective real-world data are lacking. ...
Multicenter Study
The journal of headache and pain. 2025 May 19;26(1):122. DOI:10.1186/s10194-025-02068-2 2025
The impact of CSF venous fistula embolization on patient's quality of life, a longitudinal clinical-radiological exploration [0.03%]
脑脊液静脉瘘栓塞对患者生活质量影响的临床影像学纵向研究
Malo Goapper,Liesjet E H van Dokkum,Vincent Costalat et al.
Malo Goapper et al.
Background: Transvenous Onyx embolization of cerebrospinal fluid-venous fistulas (CSFVF) is an emerging and effective treatment for symptomatic spontaneous intracranial hypotension (SIH). This condition significantly impa...
Substance P release from rat dura mater is inversely correlated with CGRP release- experiments using glycerol trinitrate and anti-CGRP antibodies [0.03%]
NO释放与CGRP释放呈负相关性的实验研究-甘油硝酸酯和抗CGRP抗体的使用
Mária Dux,Karl Messlinger
Mária Dux
Background: The neuropeptides calcitonin gene-related peptide (CGRP) and substance P are important mediators of neurogenic inflammation when they are released from activated primary nociceptive afferents. It is long evide...
Astrocytic spermidine insufficiency contributes to enhanced pain sensitivity associated with ApoE4 [0.03%]
ApoE4相关痛觉过敏与精胺不足的星形胶质细胞有关
Kaiming Yu,Xiongyao Zhou,Baolong Li et al.
Kaiming Yu et al.
Neuropathic pain is a chronic condition with limited effective treatments, closely associated with astrocytes and their role in central sensitization. Apolipoprotein E (ApoE), predominantly expressed in astrocytes in central nervous system,...
Prevalence, disability, and economic impact of migraine in Spain: a nationwide population-based study [0.03%]
西班牙全国基于人口的患病率、致残率及偏头痛带来的经济损失研究
Margarita Sanchez-Del-Rio,David García-Azorín,Carmen Peral et al.
Margarita Sanchez-Del-Rio et al.
Background: This study updates data on migraine prevalence in Spain, examining regional variations, healthcare resource utilization (HCRU), and patient-reported outcomes (PROs). ...
White matter and cortical gray matter microstructural alterations in migraine: a NODDI and DTI analysis [0.03%]
偏头痛患者白质和皮层灰质微结构的改变：NODDI和DTI研究
Zhilei Li,Yanliang Mei,Lei Wang et al.
Zhilei Li et al.
Background: The pathophysiological mechanism of migraine remains elusive, thereby impeding the effective treatment of the disease. Current neuroimaging research focuses on changes in brain functional connectivity, functio...
Ahmed Amir Samir,Ahmed W Hageen,Ahmed Elgammal et al.
Ahmed Amir Samir et al.
Introduction: Migraine is a prevalent debilitating neurological illness that stands among the top causes of disability and significantly impacts the quality of life. Migraine-related functional impairment involves physica...
Unraveling the paradox: cardiovascular risk profiling in migraine- a correspondence [0.03%]
解开悖论：偏头痛的心血管风险评估——一封来信回复
Linda Al-Hassany,Ruben W A van Drie,Deirdre M Boucherie et al.
Linda Al-Hassany et al.
We read with great interest the recent publication by Marston and colleagues in Nature Medicine, entitled "Endothelial cell-related genetic variants identify LDL cholesterol-sensitive individuals who derive greater benefit from aggressive l...
Differential inhibitory effects of endocannabinoids on neuronal firing of mouse meningeal afferents [0.03%]
内源大麻素对小鼠脑膜神经元放电的不同抑制效果
Georgii Krivoshein,Adriana Della Pietra,Juha Savinainen et al.
Georgii Krivoshein et al.
Background: Increasing endocannabinoids (endoCBs), anandamide (AEA) and 2-arachidonoylglycerol (2-AG), through inhibition of the degrading hydrolase enzymes, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (...