Twelve-months prospective real-world assessment of effectiveness and safety of eptinezumab in migraine patients difficult-to-treat and naïve to CGRP monoclonal antibodies: results of the French FHU INOVPAIN registry [0.03%]
法国FHU INOVPAIN登记处难治性偏头痛和CGRP单克隆抗体初治的偏头痛患者中Eptinezumab有效性和安全性的前瞻性真实世界一年评估结果分析
S Ferrao-Malheiro,R Fabre,T Jiacomini et al.
S Ferrao-Malheiro et al.
Background: Randomized clinical trials have demonstrated the efficacy and safety of eptinezumab. The aim of this study was to evaluate the effectiveness and safety of eptinezumab in a real-world setting among patients wit...
Interictal burden in migraine: a systematic review of conceptual domains and measurement properties of instruments [0.03%]
偏头痛间期负担的系统性综述：概念领域和测量工具属性
Cornelius Angerhöfer,Yutaro Fuse,Samuel Van Langenhove et al.
Cornelius Angerhöfer et al.
Background: Migraine imposes significant burden not only during acute attacks but also during headache-free interictal periods. Several patient-reported outcome measures (PROMs) have been used to assess this interictal bu...
Tear fluid Calcitonin gene-related peptide in patients with idiopathic intracranial hypertension headache - a prospective case-control study [0.03%]
原发性颅内高压患者头痛相关的 Tears液降钙素基因相关肽测定-前瞻性病例对照研究
Cem Thunstedt,Ad Shehi,Ozan E Eren et al.
Cem Thunstedt et al.
Background: Headache is the most common symptom of idiopathic intracranial hypertension (IIH) and may persist despite therapy, with a significant impact on quality of life. Since calcitonin gene-related peptide (CGRP) pla...
Normative structural MRI deviation factors summarize patient-level neuroanatomical heterogeneity across episodic and chronic migraine [0.03%]
规范性结构MRI偏差因素概述了不同发作性和慢性偏头痛患者的神经解剖异质性
Chenyu Dai,Mengqian Ye,Xinhao Li et al.
Chenyu Dai et al.
Background: Structural MRI findings in migraine are inconsistent across cohorts, suggesting that group contrasts may obscure patient-level heterogeneity. We tested whether individualized normative structural deviations co...
Genetic regulation of cell type-specific chromatin accessibility contributes to migraine etiology [0.03%]
基因调控的染色质可访问性影响细胞类型特异性，有助于偏头痛的发生机制
Qiuhan Xu,Zhaohui Chai,Yuning Zhang et al.
Qiuhan Xu et al.
Background: Migraine is a common and disabling neurological disorder, yet most causal regulatory variants and their target cell types remain unresolved. Disease-associated variants are enriched in non-coding cis-regulator...
Exploratory development of prediction models for pharmacotherapy outcomes in trigeminal neuralgia: a combined analysis based on multi-source data [0.03%]
基于多源数据的三叉神经痛药物治疗结局预测模型的探索性研发研究
Hongan Yang,Baijintao Sun,Mingtao Li et al.
Hongan Yang et al.
Background: Drug-refractory trigeminal neuralgia (DRTN) represents a formidable challenge in clinical management, with approximately 30%-50% of patients eventually progressing to DRTN. Early identification of high-risk DR...
From tooth pain to trigeminal sensitization: translational models, experimental readouts, and mechanism-guided therapeutic opportunities in odontogenic and headache-related orofacial pain [0.03%]
从牙痛到三叉神经敏化：与头痛相关的口面疼痛的译生医学模型、实验检测指标及靶向治疗机制机遇（以齿源性疼痛为例）
Ezgi Cansu Firinciogullari,Kiran Alluri,Hanjun Wang et al.
Ezgi Cansu Firinciogullari et al.
Odontogenic pain is one of the most intense forms of orofacial pain, yet durable mechanism-directed therapies remain limited. Traditionally, tooth pain has been framed as a local consequence of pulpal, dentinal, periodontal, or periapical d...
Source-level α periodic power in visual and default mode networks predicts topiramate treatment response in migraine [0.03%]
视觉网络和默认模式网络中的源一级α频段功率可预测托吡酯治疗偏头痛的疗效
Siyuan Xie,Chenghui Pi,Kang Jin et al.
Siyuan Xie et al.
Background: Migraine is highly heterogeneous, and patients exhibit substantial variability in their responses to preventive treatment. The dose-escalation strategy of topiramate further complicates early evaluation of the...
IRAK-M attenuates pain hypersensitivity and anxiety-like behaviors in a nitroglycerin-induced chronic migraine mouse model with concomitant reductions in microglial activation and neuroinflammation [0.03%]
IRAK-M通过减少小胶质细胞活化和神经炎症来缓解硝酸甘油诱导的慢性偏头痛鼠模型中的痛觉过敏及类似焦虑的行为
Xiao-Tao Liang,Shi-Ru Xie,Xi-Mao Liu et al.
Xiao-Tao Liang et al.
Background: Chronic migraine (CM) is a disabling neurological disorder in which neuroinflammatory mechanisms and central sensitization are thought to contribute to disease pathophysiology. Interleukin-1 receptor-associate...