Delivery Strategies for Oncolytic Viruses in Gastrointestinal Cancers: Progress, Mechanisms and Clinical Translations [0.03%]
溶瘤病毒在胃肠肿瘤递送策略中的进展、机制和临床转化研究
Chi Xue,Yanchen Liu,Changxin Yin et al.
Chi Xue et al.
Due to their complex anatomy, high heterogeneity, and immunosuppressive tumour microenvironment, gastrointestinal cancers severely restrict the effective delivery and function of oncolytic viruses (OVs). This review summarises current multi...
Convalescent Plasma Restores Viral Clearance After Anti-Spike Monoclonal Antibody Failure in Immunocompromised COVID-19 Patients: A Systematic Review and Meta-Analysis of Individual Patient Data [0.03%]
恢复期血浆治疗免疫缺陷型新冠患者的疗效：抗刺突单克隆抗体治疗失败后的清病毒效果——个体患者数据的系统评价和荟萃分析
Daniele Focosi,Tommaso Francesco Aiello,Arturo Casadevall et al.
Daniele Focosi et al.
Anti-Spike monoclonal antibodies (mAbs) progressively lost efficacy during the COVID-19 pandemic due to the emergence and predominance of resistant SARS-CoV-2 variants. By contrast, high-titre COVID-19 convalescent plasma (CCP) collected fr...
Timing, Titre, and Host Determinants of Convalescent Plasma Efficacy in COVID-19: A Systematic Review With Design-Stratified Narrative Synthesis [0.03%]
恢复期血浆治疗新冠肺炎的疗效影响因素：系统综述及设计分层叙述性综合分析
Agnieszka Kuś,Sebastian Makuch,Jarosław Dybko et al.
Agnieszka Kuś et al.
The efficacy of convalescent plasma (CP) in COVID-19 has been contested, with large randomized trials producing conflicting results that led to recommendations against routine use. We performed a systematic review with design-stratified nar...
The Changing Landscape of Hantavirus Infections: A Narrative Review of Epidemiology, Pathogenesis, and Countermeasures [0.03%]
汉坦病毒感染的演变：流行病学、发病机制和对策的叙述性综述
Francesco De Maria,Francesco Branda,Giancarlo Ceccarelli et al.
Francesco De Maria et al.
Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human-animal int...
Hantavirus: A Comprehensive Narrative Review of Virology, Epidemiology, Pathogenesis, Clinical Manifestations, Diagnostics, and Emerging Therapeutic Strategies [0.03%]
汉坦病毒：一篇关于病毒学、流行病学、发病机制、临床表现、诊断和新兴治疗策略的综述文章
Muhammad Kamran,Muhammad Bilal Habib,Adeel Shahid et al.
Muhammad Kamran et al.
Hantaviruses are a genus of negative-sense, single-stranded, tri-segmented RNA viruses that are distributed worldwide. They cause two severe zoonotic diseases in humans: haemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary...
John Cunningham Virus and Colorectal Carcinogenesis: Current Evidence, Molecular Mechanisms, and Unresolved Controversies [0.03%]
约翰·坎宁安病毒与结直肠癌发生发展：现有证据、分子机制及未解争议
Ziqing Zhou,Ziqi Wang,Liman Xi et al.
Ziqing Zhou et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide, prompting ongoing research into infectious agents that may contribute to colorectal carcinogenesis. Among candidate oncogenic viruses, JC polyomavirus (JCPyV...
Human Sapovirus in the Post-Rotavirus Vaccine Era: From an Overlooked Gastroenteritis Pathogen to a Target for Precision Surveillance [0.03%]
人 sapovirus 在轮状病毒疫苗时代后的研究：从被忽视的胃肠炎病原体到精准监测的目标
Chunhua Wang,Yanfei Tong,Jiali Sun et al.
Chunhua Wang et al.
Human sapovirus (HuSaV) has long occupied a peripheral position in etiological research on acute gastroenteritis. However, in the context of widespread rotavirus vaccination, the pathogen spectrum of childhood diarrhoea has been reshaped; m...
West Nile Neuroinvasive Disease: Current Management, Emerging Therapies and Future Clinical Trial Priorities [0.03%]
西尼罗脑炎的当前治疗、新兴疗法及未来临床试验优先事项
Ambrogio Curtolo,Dimitra Kontogiannis,Tommaso Ascoli Bartoli et al.
Ambrogio Curtolo et al.
West Nile virus (WNV) is a climate-sensitive, mosquito-borne flavivirus that has become endemic in Europe, with Italy, particularly the Lazio region, emerging as a significant epicentre. While most infections are asymptomatic, less than 1% ...
Oncogenic Viruses and Inhaled Microplastics: A Double Hit Hypothesis for Asthma Progression and Lung Cancer Development [0.03%]
致癌病毒和吸入的微塑料：哮喘进展和肺癌发生的双重打击假说
Jiacheng Yin,Muzhe Su,Minhao Xu et al.
Jiacheng Yin et al.
Oncogenic viruses have emerged as potential contributors to chronic airway disease and lung carcinogenesis through mechanisms involving viral persistence, immune evasion, genomic instability, and sustained inflammation. Increasing evidence ...
Dysregulated Metabolism in People Living With HIV in the Modern ART-Era: A Systematic Review of Targeted Metabolomics Studies [0.03%]
高效抗逆转录病毒治疗时代HIV感染者代谢紊乱的代谢组学研究系统综述
Levanco K Asia,Du Toit Loots,Shayne Mason et al.
Levanco K Asia et al.
HIV remains a significant public health issue, with 1.3 million new infections and 630,000 deaths annually, and 40.8 million people living with HIV (PLHIV) globally in 2024. Although antiretroviral therapy (ART) suppresses viral replication...