DMC (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone) enhances exercise tolerance via the AMPK-SIRT1-PGC-1α pathway in mice fed a high-fat diet [0.03%]
2’,4’-二羟基-6’-甲氧基-3’,5’-二甲基查耳酮通过AMPK-SIRT1-PGC-1α信号通路改善高脂饮食喂养小鼠的运动耐力
Xiaotong Su,Linglin Lai,Xu Li et al.
Xiaotong Su et al.
Obesity is caused by an imbalance between energy intake and energy expenditure. This study aimed to determine the effects and mechanisms of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) on exercise tolerance in high-fat diet (HFD)...
Pretreatment with Notoginsenoside R1 attenuates high-altitude hypoxia-induced cardiac injury via activation of the ERK1/2-P90RSK-Bad signaling pathway in rats [0.03%]
红参皂苷Rg3通过激活ERK1/2-p90RSK-Bad信号转导通路减轻大鼠高原低氧性心肌损伤
Sijing Zhao,Nan Jia,Zherui Shen et al.
Sijing Zhao et al.
High-altitude cardiac injury (HACI) is one of the common tissue injuries caused by high-altitude hypoxia that may be life threatening. Notoginsenoside R1 (NG-R1), a major saponin of Panax notoginseng, exerts anti-oxidative, anti-inflammator...
Effect of Citrus bergamia extract on lipid profile: A combined in vitro and human study [0.03%]
意大利柑橘提取物对血脂谱的作用：一项结合体外和人体的研究
Maria Pierdomenico,Arrigo F G Cicero,Maddalena Veronesi et al.
Maria Pierdomenico et al.
With the aim of characterising the hypo-lipidemic function of the Brumex™ ingredient obtained from the whole fruit of Citrus bergamia, a combined pre-clinical and clinical study was conducted. In the HepG2 experimental model, we first demo...
Randomized Controlled Trial
Phytotherapy research : PTR. 2023 Sep;37(9):4185-4195. DOI:10.1002/ptr.7897 2023
l-borneol promotes neurovascular unit protection in the subacute phase of transient middle cerebral artery occlusion rats: p38-MAPK pathway activation, anti-inflammatory, and anti-apoptotic effect [0.03%]
脑梗死后亚急性期左旋薄荷醇促进神经血管单元保护：活化p38-MAPK通路、抗炎及抑制凋亡作用
Qian Xie,Danni Lu,Jianmei Yuan et al.
Qian Xie et al.
Our previous study showed l-borneol reduced cerebral infarction in the acute stage after cerebral ischemia, but there is little about the study of subacute phase. We herein investigated the cerebral protective effects of l-borneol on neurov...
A comprehensive insight into the molecular effect of theobromine on cardiovascular-related risk factors: A systematic review of in vitro and in vivo studies [0.03%]
一项关于茶碱对心血管相关风险因素的分子作用影响的全面见解：体外及体内研究的系统性回顾
Elham Sharifi-Zahabi,Fatemeh Hajizadeh-Sharafabad,Seyed Mostafa Nachvak et al.
Elham Sharifi-Zahabi et al.
Theobromine may have beneficial effects on cardiovascular risk factors. This study aimed to find molecular effects of theobromine on lipid profile, glycemic status, inflammatory factors, and vascular function through a comprehensive assessm...
Correction to "The mechanism of mulberry leaves against renal tubular interstitial fibrosis through ERK1/2 signaling pathway was predicted by network pharmacology and validated in human tubular epithelial cells" [0.03%]
基于网络药理学预测并用人肾小管上皮细胞验证桑叶抗肾小管间质纤维化的机制通过ERK1/2信号通路
Published Erratum
Phytotherapy research : PTR. 2023 Aug;37(8):3645-3647. DOI:10.1002/ptr.7832 2023
Bavachinin selectively modulates PPAR γ and maintains bone homeostasis in Type 2 Diabetes [0.03%]
巴瓦チンin选择性调节PPARγ维持2型糖尿病骨稳态
Jingwen Liu,Xiaoye Li,Hong Wang et al.
Jingwen Liu et al.
Full peroxisome proliferator-activated receptor (PPAR) γ agonists, Thiazolidinediones (TZDs), effectively prevent the process of Type 2 Diabetes Mellitus (T2DM), but their side effects have curtailed use in the clinic, including weight gai...
11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E2 /ERβ signaling pathways [0.03%]
11-乙氧基 Viburtinal通过PI3K/Akt和E2/ERβ信号通路改善慢性束缚应激诱导的雄性特异性小鼠焦虑样行为
Yan Lyu,Xiaojia Wei,Xue Yang et al.
Yan Lyu et al.
Anxiety disorder is a chronic and disabling psychiatric disorder that is more prevalent in females than in males. 11-Ethoxyviburtinal is an iridoid extracted from Valeriana jatamansi Jones, which has anxiolytic potential. The aim of the pre...
Baicalin promotes random-pattern skin flap survival by inducing autophagy via AMPK-regulated TFEB nuclear transcription [0.03%]
baicalin通过AMPK调节的TFEB核转录诱导自噬促进随机皮瓣存活
Lilian Zhang,Gaoxiang Yu,Qing Yu et al.
Lilian Zhang et al.
The random-pattern skin flap is a generally used technique to cover the soft tissue defect, while its application is often constrained by complications after the flap transplant. Necrosis of the flap remains a principal obstacle. The purpos...
Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway [0.03%]
鼠李茋通过抑制PI3K/Akt/mTOR信号通路诱导胃癌细胞凋亡和保护性自噬
Pengzhan He,Yang He,Jingjing Ma et al.
Pengzhan He et al.
Gastric cancer (GC) is often diagnosed in the advanced stages with a poor prognosis. Thymoquinone (TQ) is known for its antitumor activity; however, the specific mechanism in GC remains unknown. In our study, TQ inhibited GC cell proliferat...