Salvianolic Acid A Inhibits Ferroptosis in Endothelial Cells and the Progression of Atherosclerosis by Augmenting the Mitochondrial Homeostasis Pathway Associated With Adiponectin Receptor 1 [0.03%]
天冬酸通过增强与载脂蛋白尿素受体1相关的线粒体稳态通路抑制内皮细胞铁死亡和动脉粥样硬化的发展
Ji Zhu,Jianan Guo,Jing Liu et al.
Ji Zhu et al.
Endothelial cell ferroptosis drives atherosclerosis. Salvianolic acid A (SAA), a polyphenol from Salvia species, was tested for its ability to inhibit ferroptosis and attenuate atherosclerosis, and its molecular mechanism was investigated. ...
Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects [0.03%]
转录组推断和系统研究具有有益代谢作用的中药化合物的方法
Jing Li,Yang-Chi-Dung Lin,Hsi-Yuan Huang et al.
Jing Li et al.
Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogen...
Targeting TIME With Phytochemicals: A Promising Approach Against Lung Cancer [0.03%]
利用植物化学物质靶向调控转录共激活分子TIME对抗肺癌的潜在新策略
Feng Xiang,Liyue Lu,Fangfei Li et al.
Feng Xiang et al.
Lung cancer remains an aggressive and highly prevalent disease worldwide, causing an estimated 1.8 million deaths in 2022 and becoming a leading cause of cancer-related mortality. Resistance to current therapies necessitates novel approache...
Interventional Potential of Panax Genus Chinese Medicinals in Atherosclerosis Progression [0.03%]
人参属中药干预动脉粥样硬化进展的潜在价值
Wenjing Li,Haiyan Li,Ronghua Zhao et al.
Wenjing Li et al.
Atherosclerosis and its complications significantly affect human health globally. The etiology of atherosclerosis is multifaceted, with current research focusing on abnormalities in lipid metabolism, immune cell activation, inflammation, an...
Luteoloside Inhibits the Progression and Enhances Chemosensitivity to Cytarabine in Acute Myeloid Leukemia via β-Catenin/c-Myc Axis [0.03%]
金丝桃苷通过β-连环素/c-MYC轴抑制急性髓系白血病的发展并增强其对阿糖胞苷的敏感性
Xiaofang Wang,Fan Zhao,Yangya Pan et al.
Xiaofang Wang et al.
Acute myeloid leukemia (AML) is one of the most common and lethal hematologic malignancies with limited possibilities for treatment. Thus, more effective therapeutic drugs are imperatively needed to fulfill current unmet medical requirement...
Atractylenolide I Alleviates Lipotoxicity in Hepatocytes and Protects NAFLD in Mice Through SIRT1-Dependent IRE1α-XBP1 Pathway [0.03%]
白术内酯I通过SIRT1依赖的IRE1α-XBP1信号通路缓解肝细胞脂毒性及防治小鼠NAFLD
Hui Zhuge,Kaixin Chang,Shuzhen Sun et al.
Hui Zhuge et al.
Atractylenolide I (AO-I), a major pharmacological ingredient derived from Atractylodes macrocephala, has been reported to possess multiple bioactivities. This study aimed to investigate the potential protective effects of AO-I against lipot...
Lycium barbarum Leaf Flavonoids Exert Anti-Aging Effects by Regulating the Keap1-Nrf2-HO-1 and Cell Adhesion Molecule Signaling Pathways [0.03%]
枸杞叶黄酮通过调节Keap1-Nrf2-HO-1和细胞黏附分子信号通路发挥抗衰老作用
Jinwang Liu,Xue Yang,Xiaotong Zha et al.
Jinwang Liu et al.
Aging significantly increases susceptibility to chronic diseases, underscoring the need for effective interventions. Flavonoids from Lycium barbarum leaves (LBLF), which are notably more abundant in the leaves than in the berries, have demo...
Broussonin A Attenuates Type 2 Diabetic Osteoporosis by Reactivating JAK2/STAT3 Signaling to Inhibit Ferroptosis in BMSCs [0.03%]
白术内酯A通过活化JAK2/STAT3信号通路抑制BMSCs铁死亡从而防治2型糖尿病骨质疏松症
Yangfan Guo,Yixun Huang,Lijiang Han et al.
Yangfan Guo et al.
Type 2 diabetic osteoporosis (T2DOP) significantly impairs bone health, partially through ferroptosis triggered by glucolipotoxicity. However, therapeutic strategies targeting this process remain largely unexplored. Broussonin A (BRA), a na...
Curcumin as a Multifaceted Epigenetic Modulator With a Disease-Oriented Perspective [0.03%]
从疾病角度研究多效性表观遗传调控剂姜黄素
Hedieh Sadat Shamsnia,Mahtab Roustaei,Amirreza Peyrovinasab et al.
Hedieh Sadat Shamsnia et al.
Curcumin (diferuloylmethane), a polyphenolic compound, is a component of Curcuma longa, commonly known as turmeric. It is well known for its therapeutic properties in a variety of diseases. One of its distinctive mechanisms is epigenetic mo...
A Critical Review of Cytochrome P450 Enzyme Inhibition by Herbal Phytochemicals: Implications for Drug Interaction Prediction and Herbal Safety [0.03%]
中药植物化学成分对细胞色素P450酶抑制作用的批判性评述——对药物相互作用预测及中药安全性的影响
Yanping Li,Lanlan Gan,Yuanlin Wu et al.
Yanping Li et al.
Cytochrome P450 (CYP450) enzymes are the most important phase I drug-metabolizing enzymes in humans, and regulation of their activity is directly related to drug efficacy and safety. As herbal medicines gain worldwide popularity, their conc...