Icariin, a phytoestrogen, exerts rapid estrogenic actions through crosstalk of estrogen receptors in osteoblasts [0.03%]
淫羊藿黄酮成分冰片通茋素通过与雌激素受体互作在成骨细胞中发挥速效雌激素样作用
Ka-Ying Wong,Tsz-Hung Kong,Christina Chui-Wa Poon et al.
Ka-Ying Wong et al.
Icariin, a flavonoid glycoside derived from Epimedium brevicornum Maxim, exerts bone protective effects via estrogen receptors (ERs). This study aimed to investigate the role of ER-α66, ER-α36, and GPER in bone metabolism in osteoblasts f...
A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review [0.03%]
白藜芦醇对脓毒症并发症的分子和细胞作用机制的全面见解——系统性回顾
Mahdi Vajdi,Pouria Sefidmooye Azar,Ata Mahmoodpoor et al.
Mahdi Vajdi et al.
Sepsis and septic shock are still one of the most important medical challenges. Sepsis is an extreme and uncontrolled response of the innate immune system to invading pathogenesis. Resveratrol (3,5,4'-trihydroxytrans-stilbene), is a phenoli...
Chelerythrine chloride inhibits the progression of colorectal cancer by targeting cancer-associated fibroblasts through intervention with WNT10B/β-catenin and TGFβ2/Smad2/3 axis [0.03%]
通过干预WNT10B/β-连环蛋白和TGFβ2/Smad2/3轴靶向癌相关成纤维细胞抑制千金藤素氯化物诱导的结直肠癌进展
Dan Liang,Lu Liu,Qiao Zheng et al.
Dan Liang et al.
Chelerythrine chloride (CHE) is a benzodiazepine alkaloid derived from natural herbs with significant anti-tumor and anti-inflammatory activities. However, the exact role and underlying mechanisms of CHE in colorectal cancer (CRC) remain un...
Ameliorative effect of Luffa cylindrica fruits on Caenorhabditis elegans and cellular models of Alzheimer's disease-related pathology via autophagy induction [0.03%]
葫芦果通过诱导自噬改善阿尔茨海默病病理相关的线虫和细胞模型的疗效研究
Tao Long,Xue Chen,Da-Lian Qin et al.
Tao Long et al.
Background: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder without an effective cure. Natural products, while showing promise as potential therapeutics for AD, remain underexplored. ...
Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review [0.03%]
基于中西医理论理解的阿尔茨海默病干预中天然活性成分的新进展和新趋势综述
Weiye Li,Yifeng Rang,Huan Liu et al.
Weiye Li et al.
Alzheimer's disease (AD) is one of the major neurological disorders causing death in the elderly worldwide. As a neurodegenerative disease that is difficult to prevent and cure, the pathogenesis of AD is complex and there is no effective cu...
Atractylenolide-III alleviates osteoarthritis and chondrocyte senescence by targeting NF-κB signaling [0.03%]
三七茋醇通过靶向NF-κB信号减轻骨关节炎和软骨细胞衰老作用
Yizhou Xu,Xiaofang Hu,Jiale Cai et al.
Yizhou Xu et al.
Atractylenolide-III (AT-III) is well known as its role in antioxidant and anti-inflammatory. Present study was aimed to figure out its effects on osteoarthritis and potential mechanisms. Rat model, human osteoarthritis cartilage explants as...
Tenuifolin in the prevention of Alzheimer's disease-like phenotypes: Investigation of the mechanisms from the perspectives of calpain system, ferroptosis, and apoptosis [0.03%]
藤茶素在预防阿尔茨海默病表型中的作用机制研究：钙蛋白酶系统、铁死亡及凋亡角度分析
Congting Li,Feng Gao,Yan Qu et al.
Congting Li et al.
Polygala tenuifolia was documented to calm the mind and promote wisdom. However, its underlying mechanisms are still unclear. This study aimed to investigate the mechanisms underlying the effects of tenuifolin (Ten) on Alzheimer's disease (...
Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase [0.03%]
鼠李素通过螯合铁和与花生四烯酸15-脂氧化酶相互作用抑制铁死亡从而缓解慢性阻塞性肺病
Lu Liu,Yunsen Zhang,Lun Wang et al.
Lu Liu et al.
Ferroptosis, an iron-dependent cell death characterized by lethal lipid peroxidation, is involved in chronic obstructive pulmonary disease (COPD) pathogenesis. Therefore, ferroptosis inhibition represents an attractive strategy for COPD the...
Urolithin A: A promising selective estrogen receptor modulator and 27-hydroxycholesterol attenuator in breast cancer [0.03%]
尿石酸A：乳腺癌中一种有前景的雌激素受体调节剂和27-羟基胆固醇抑制剂
Ravindran Vini,Vishnu Sunil Jaikumar,Viji Remadevi et al.
Ravindran Vini et al.
27-hydroxycholesterol (27-HC) is an oxysterol that acts as an endogenous selective estrogen receptor modulator (SERM), and its adverse effects on breast cancer via the estrogen receptor (ER) have provided new insights into the pathology of ...
The effects of Capsicum annuum supplementation on lipid profiles in adults with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials [0.03%]
辣椒属补充剂对代谢综合征成人脂质轮廓的影响：随机对照试验的系统评价和荟萃分析
Ahmed Hjazi
Ahmed Hjazi
The electiveness of Capsicum annuum supplementation in controlling dyslipidemia in adults has been unclear. Therefore, this meta-analysis focuses on the relationship between C. annuum supplementation and lipid profile in adults with metabol...