Paeoniflorin suppresses neuronal ferroptosis to improve the cognitive behaviors in Alzheimer's disease mice [0.03%]
芍药苷通过抑制神经元铁死亡改善阿尔茨海默病小鼠的认知行为
Liping Zhai,Hongyan Pei,Heping Shen et al.
Liping Zhai et al.
Aim of this research was to examine the impact of paeoniflorin (Pae) in suppressing the occurrence of ferroptosis in individuals with Alzheimer's disease (AD). The study utilized APP/PS1 mice with AD as the experimental subjects. Following ...
Enterolactone and trabectedin suppress epithelial ovarian cancer synergistically via upregulating THBS1 [0.03%]
雌酚酮和曲贝替定通过上调THBS1协同抑制卵巢癌
Zheng Zeng,Caiji Lin,Meng-Chun Zhang et al.
Zheng Zeng et al.
Epithelial ovarian cancer (EOC) is the most common and fatal subtype of ovarian malignancies, with no effective therapeutics available. Our previous studies have demonstrated extraordinary suppressive efficacy of enterolactone (ENL) on EOC....
Medicinal plant molecules against hepatitis C virus: Current status and future prospect [0.03%]
抗丙型肝炎病毒的药用植物分子：现状与前景
Anirban Mandal,Banasri Hazra
Anirban Mandal
Hepatitis C virus (HCV), a global malady, causes acute and chronic hepatitis leading to permanent liver damage, hepatocellular carcinoma, and death. Modern anti-HCV therapies are efficient, but mostly inaccessible for residents of underdeve...
NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer's disease-like pathology in mice by targeting protein phosphatase magnesium-dependent 1A phosphatase [0.03%]
绞股蓝成分NPLC0393通过靶向蛋白磷酸酶Mg2+/Mn2+依赖型1A改善小鼠的阿尔茨海默病病理表型
Jianlu Lv,Xingyi Shen,Xinya Shen et al.
Jianlu Lv et al.
Alzheimer's disease (AD) is a neurodegenerative disease with clinical hallmarks of progressive cognitive impairment and memory loss. Gynostemma pentaphyllum ameliorates cognitive impairment, but the mechanisms remain obscure. Here, we deter...
Recent insights into the nutritional immunomodulation of cancer-related microRNAs [0.03%]
营养免疫调节与癌症相关MicroRNA的最新研究进展
Teslime Özge Şahin,Birsen Yılmaz,Neslihan Yeşilyurt et al.
Teslime Özge Şahin et al.
Cancer is the most common cause of death worldwide, following cardiovascular diseases. Cancer is a multifactorial disease and many reasons such as physical, chemical, biological, and lifestyle-related factors. Nutrition, which is one of the...
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol [0.03%]
通过抑制沉默信息调节因子1（SIRT1）的作用，艾纳香醇减少体重增加并调节情绪障碍
Vittoria Borgonetti,Clarissa Caroli,Paolo Governa et al.
Vittoria Borgonetti et al.
The prevalence of obesity is steadily rising, making safe and more efficient anti-obesity treatments an urgent medical need. Growing evidence correlates obesity and comorbidities, including anxiety and depression, with the development of a ...
Antidiabetic, hypolipidemic, and antioxidant activities of Pistacia atlantica: A systematic review and meta-analysis of preclinical studies [0.03%]
毛梾的抗糖尿病、降血脂和抗氧化活性：临床前研究的系统评价和meta分析
Razieh Choghakhori,Amir Abbasnezhad,Mohammad Yazdi et al.
Razieh Choghakhori et al.
To determine the pharmaceutical applications, we assessed the evidence from preclinical studies about the hypoglycemic, hypolipidemic, and antioxidant potential of Pistacia atlantica (PA) as a natural source for prevention and treatment of ...
Cryptotanshinone alleviates radiation-induced lung fibrosis via modulation of gut microbiota and bile acid metabolism [0.03%]
cryptotanshinone通过调节肠道微生物群和胆汁酸代谢来缓解放射性肺纤维化
Zhanhong Li,Yunheng Shen,Jiayun Xin et al.
Zhanhong Li et al.
Cryptotanshinone (CPT), a major biological active ingredient extracted from root of Salvia miltiorrhiza (Danshen), has shown several pharmacological activities. However, the effect of CPT on radiation-induced lung fibrosis (RILF) is unknown...
20(S)- Protopanaxadiol saponins isolated from Panax notoginseng target the binding of HMGB1 to TLR4 against inflammation in experimental ulcerative colitis [0.03%]
来源于三七中（20S）-原人参二醇皂苷通过靶向HMGB1与TLR4的相互作用发挥抗炎效应并治疗实验性溃疡性结肠炎
Jinfen Chen,Pengde Lu,Jiayue Liu et al.
Jinfen Chen et al.
Ulcerative colitis (UC) has emerged as a global healthcare issue due to high prevalence and unsatisfying therapeutic measures. 20(S)- Protopanaxadiol saponins (PDS) from Panax notoginseng with anti-inflammatory properties is a potential ant...
Effects of adjuvant berberine therapy on acute ischemic stroke: A meta-analysis [0.03%]
辅以小檗碱治疗对于急性脑梗塞的效果：一项荟萃分析研究
Dan Luo,Baili Yu,Shoukai Sun et al.
Dan Luo et al.
We conducted a meta-analysis to evaluate the clinical efficacy of berberine (BBR) in treating acute ischemic stroke (AIS), explore its anti-inflammatory effects, and assess its potential applications for AIS patients. We comprehensively sea...