Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT [0.03%]
肉桂紫草素通过干扰HSP90和AKT的相互作用抑制胃癌的发生发展
Xiaoli Li,Guoli Wang,Xiaolin Zhou et al.
Xiaoli Li et al.
Gastric cancer (GC) is one of the most common malignant tumors worldwide. Thus, the development of safe and effective therapeutic compounds for GC treatment is urgently required. Here, we aimed to examine the role of picropodophyllin (PPP),...
Priyanka Joshi,Akansha Bisht,Ajita Paliwal et al.
Priyanka Joshi et al.
Curcumin, a natural polyphenol, derived from Curcuma longa L. is extensively studied by various researchers across the globe and has established its immense potential in the management of several disorders at clinical level. The underlying ...
Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases [0.03%]
脂肪酸代谢紊乱与心血管病治疗中药物发现
Xianfeng Liu,Xinmei Xu,Tao Zhang et al.
Xianfeng Liu et al.
Cardiovascular diseases are currently the primary cause of mortality in the whole world. Growing evidence indicated that the disturbances in cardiac fatty acid metabolism are crucial contributors in the development of cardiovascular disease...
An outlook on the target-based molecular mechanism of phytoconstituents as immunomodulators [0.03%]
植物成分作为免疫调节剂的靶向分子机制展望
Gazala Noor,Badruddeen,Juber Akhtar et al.
Gazala Noor et al.
The immune system is one of the essential defense mechanisms. Immune system inadequacy increases the risk of infections and cancer diseases, whereas over-activation of the immune system causes allergies or autoimmune disorders. Immunomodula...
Saffron (Crocus sativus) and its constituents for pain management: A review of current evidence [0.03%]
藏红花(Crocus sativus)及其成分在疼痛管理中的应用：现有证据综述
Ali Mohammad Pourbagher-Shahri,Fatemeh Forouzanfar
Ali Mohammad Pourbagher-Shahri
Pain can become a chronic and deliberating experience with a significant burden. In preclinical and clinical studies, Saffron (Crocus sativus L.) has shown analgesic activities. Considering the unsatisfactory results of current therapeutic ...
Ginkgolide K delays the progression of osteoarthritis by regulating YAP to promote the formation of cartilage extracellular matrix [0.03%]
银杏内酯K通过调节YAP促进软骨细胞外基质形成来延缓骨关节炎的进展
Ruizhou Liu,Zhendong Liu,Hui Chen et al.
Ruizhou Liu et al.
Osteoarthritis (OA) is a degenerative disease characterized by cartilage wear and degradation. Ginkgolide K (GK) is a natural compound extracted from Ginkgo biloba leaves and possesses anti-inflammatory and anti-apoptotic effects. We found ...
Association between cannabis use and risk of diabetes mellitus type 2: A systematic review and meta-analysis [0.03%]
大麻使用与二型糖尿病发病风险之间关系的系统评价和meta分析
Seyed Ehsan Mousavi,Farhad Tondro Anamag,Sarvin Sanaie
Seyed Ehsan Mousavi
Background: Cannabis consumption exerts multiple effects on metabolism via various pathways, including glucose regulation and insulin secretion. Studies concerning the association between cannabis use and diabetes mellitu...
Apigenin inhibits macrophage pyroptosis through regulation of oxidative stress and the NF-κB pathway and ameliorates atherosclerosis [0.03%]
芹菜素通过调节氧化应激和NF-κB途径抑制巨噬细胞焦亡并改善动脉粥样硬化
Xiuzhu Weng,Xing Luo,Xinyu Dai et al.
Xiuzhu Weng et al.
Pyroptosis plays an important role in inflammatory diseases such as viral hepatitis and atherosclerosis. Apigenin exhibits various bioactivities, particularly anti-inflammation, but its effect on pyroptosis remains unclear. The aim of this ...
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma [0.03%]
长春花生物碱通过激活内质网应激抑制食管鳞癌生长
Ronghui Fan,Senzhen Wang,Yalan Wu et al.
Ronghui Fan et al.
The worldwide overall 5-year survival rate of esophageal squamous cell carcinoma (ESCC) patients is less than 20%, and novel therapeutic strategies for these patients are urgently needed. Harmine is a natural β-carboline alkaloid, which re...
Cannabidiol tempers alcohol intake and neuroendocrine and behavioural correlates in alcohol binge drinking adolescent rats. Focus on calcitonin gene-related peptide's brain levels [0.03%]
cannabidiol缓和酒精摄入及其神经内分泌和行为相关性：以降钙素基因相关肽的大脑水平为研究重点酒精滥饮的青少年大鼠模型中的作用
Giuseppe Tringali,Gianluca Lavanco,Valentina Castelli et al.
Giuseppe Tringali et al.
Alcohol binge drinking is common among adolescents and may challenge the signalling systems that process affective stimuli, including calcitonin gene-related peptide (CGRP) signalling. Here, we employed a rat model of adolescent binge drink...