Polyphyllin VII induces autophagy-dependent ferroptosis in human gastric cancer through targeting T-lymphokine-activated killer cell-originated protein kinase [0.03%]
黄连碱VII通过靶向T淋巴细胞激活的杀伤细胞来源的蛋白激酶诱导人类胃癌自噬依赖性铁死亡
Yuchen Xiang,Fang Wan,Yuliang Ren et al.
Yuchen Xiang et al.
T-lymphokine-activated killer cell-originated protein kinase (TOPK) is a serine-threonine kinase that is overexpressed in gastric cancer (GC) and promotes tumor progression. Polyphyllin VII (PPVII), a pennogenin isolated from the rhizomes o...
Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways [0.03%]
当归多糖通过PPARγ/SOD2/ROS信号途径改善骨关节炎软骨细胞线粒体代谢功能
Su Ni,Ning Yi,Hang Yuan et al.
Su Ni et al.
Osteoarthritis (OA) is a common degenerative joint disease, which is characterized by wear of articular cartilage and narrow joint space, resulting in joint movement disorder. At present, accurate molecular mechanisms and effective interven...
Targeting the programmed cell death (PCD) signaling mechanism with natural substances for the treatment of diabetic cardiomyopathy (DCM) [0.03%]
靶向细胞程序性死亡信号通路治疗糖尿病心肌病
Xiaoyu Xuan,Shiliang Zhang
Xiaoyu Xuan
Diabetic cardiomyopathy (DCM) is one of the severe complications of diabetes, characterized by structural and functional abnormalities in the hearts of diabetic patients without hypertension, coronary heart disease, or valvular heart diseas...
Recent advances in pyroptosis, liver disease, and traditional Chinese medicine: A review [0.03%]
焦亡的最新研究进展及其在肝病和中药研究中的应用：综述
Wenxing He,Canli Xu,Dewen Mao et al.
Wenxing He et al.
In recent years, the incidence of liver disease has increased, becoming a major cause of death. Various liver diseases are intricately linked to pyroptosis, which is one of the most common forms of programmed cell death. As a powerful weapo...
Epigallocatechin gallate circumvents drug-induced resistance in non-small-cell lung cancer by modulating glucose metabolism and AMPK/AKT/MAPK axis [0.03%]
表没食子儿茶素没食子酸酯通过调节葡萄糖代谢和AMPK / AKT / MAPK轴克服非小细胞肺癌的耐药性
Yan Zhou,Shiqi Huang,Yizhen Guo et al.
Yan Zhou et al.
Upon prolonged use of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC), acquired drug resistance inevitably occurs. This study investigates the combined use of EGFR-TKIs (gefiti...
Corrigendum to "Antiplatelet effect of ginkgo diterpene lactone meglumine injection in acute ischemic stroke: A randomized, double-blind, placebo-controlled clinical trial" [0.03%]
“银杏二萜内酯甲麦角新碱抗血小板聚集作用急性缺血性脑卒中患者中的疗效评价：随机、双盲、安慰剂对照临床试验”订正 notice
Published Erratum
Phytotherapy research : PTR. 2023 Oct;37(10):4862. DOI:10.1002/ptr.7980 2023
Epinodosin suppresses the proliferation, invasion, and migration of esophageal squamous cell carcinoma by mediating miRNA-143-3p/Bcl-2 axis [0.03%]
表皮生长因子诱导的新型蛋白通过介导miRNA-143-3p/Bcl-2轴抑制食管鳞癌增殖、侵袭和迁移
Huiping Chen,Yamei Li,Yixian Liu et al.
Huiping Chen et al.
Epinodosin has shown antibacterial and antitumor biological characteristics in the documents. We found that Epinodosin has an effective inhibitory effect on esophageal squamous cell carcinoma (ESCC). However, the potential roles and mechani...
Achyrocline satureioides as an adjuvant therapy for the management of mild viral respiratory infections in the context of COVID-19: Preliminary results of a randomized, placebo-controlled, and open-label clinical trial [0.03%]
Achyrocline satureioides作为辅助治疗在COVID-19背景下治疗轻度病毒性呼吸道感染的初步研究成果：一项随机、安慰剂对照及开放标签临床试验
Catherina Isdra Moszkowicz Bastos,Caroline Dani,Laura Reck Cechinel et al.
Catherina Isdra Moszkowicz Bastos et al.
We evaluated the impact of an Achyrocline satureioides inflorescence infusion on the clinical outcomes of viral respiratory infections, including those caused by SARS-CoV-2, in a monocentric, randomized, open-label, placebo-controlled clini...
Randomized Controlled Trial
Phytotherapy research : PTR. 2023 Nov;37(11):5354-5365. DOI:10.1002/ptr.7976 2023
Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1α pathway in Schwann cells [0.03%]
肉桂酰素通过抑制铁死亡和激活AMPK/SIRT1/PGC-1α信号通路缓解高糖诱导的雪旺细胞周围神经病变
Man Hu,Wen Jiang,Chen Ye et al.
Man Hu et al.
Schwann cells injury induced by high glucose (HG) contributes to the development of diabetic peripheral neuropathy (DPN). Honokiol has been reported to regulate glucose metabolism, however, its effect on DPN and the precise molecular mechan...
Angelica sinensis polysaccharide ameliorates nonalcoholic fatty liver disease via restoring estrogen-related receptor α expression in liver [0.03%]
当归多糖通过恢复肝脏雌激素相关受体α表达改善非酒精性脂肪肝病
Li Luo,Huafeng Zhang,Weiliang Chen et al.
Li Luo et al.
Angelica sinensis polysaccharide (ASP) showed increasingly recognized hepatoprotective effects and lipid regulation. Because polysaccharides are typically degraded into fragments or short-chain fatty acids in the gut, rather than being abso...