Sanguinarine Induces ROS-Mediated Mitochondrial Dysfunction and Inhibits AKT/GSK3 Signaling to Potentiate Apoptotic Effects in Cutaneous T-Cell Lymphoma [0.03%]
小蘖胺通过诱导活性氧介导的线粒体功能障碍并抑制AKT/GSK3信号通路来增强其在皮肤t细胞淋巴瘤中诱导凋亡的作用
Shilpa Kuttikrishnan,Muhammad Suleman,Fareed Ahmad et al.
Shilpa Kuttikrishnan et al.
Cutaneous T-cell lymphoma (CTCL) is a rare non-Hodgkin lymphoma with limited durable treatment options and poor overall survival, underscoring the need for new therapeutic approaches. Sanguinarine (SNG), a natural benzophenanthridine alkalo...
Curcumin and Its Protein Targets: Literature Review and Systems Biology Analysis [0.03%]
姜黄素及其蛋白靶点的文献综述与系统生物学分析
Pavel V Ershov,Yuri V Mezentsev,Evgeniy O Yablokov et al.
Pavel V Ershov et al.
The pleiotropic pharmacological action of curcumin, a compound derived from Curcuma longa L. rhizome, may result from its direct interaction with key cellular proteins or modulation of their gene expression. Despite the focus on elucidating...
Mechanism of Action and Research Progress of Flavonoids From Traditional Chinese Medicine to Improve Metabolic Liver Disease [0.03%]
从中药黄酮改善代谢性肝病作用机制及研究进展
Xuehui Tao,Jianing Liu,Fangtong Li et al.
Xuehui Tao et al.
Metabolic liver disease seriously affects the health of the organism and often manifests as non-alcoholic fatty liver disease (MAFLD). MAFLD is a metabolic stress disorder characterized by excessive fat deposition in hepatocytes in addition...
Trends and Patterns for the Use of Herbal Medicinal Products for Gynaecological Ailments [0.03%]
草药妇科用药的发展趋势及模式分析研究
Alexandra Drebka,Annika J Scholl,Teresa Ochs et al.
Alexandra Drebka et al.
Most Germans consider herbal medicinal products (HMPs) to be an important supplement to conventional medicine. Despite existing clinical evidence for safety and efficacy, they are still not sufficiently integrated into drug therapy of gynae...
Celastrus paniculatus Willd.: An Extensive Review of Phytochemistry, Traditional Uses, Pharmacological Potential, and Safety Profile [0.03%]
Celastrus paniculatus Willd.：化学、传统用途、药理潜力和安全性的全面综述
Nitish Kumar,Vikas Jaitak
Nitish Kumar
Celastrus paniculatus Willd., a perennial, climbing shrub, holds a significant place in traditional Indian medical systems, including Ayurveda, Unani, and Siddha. Its broad therapeutic relevance is underpinned by a chemically diverse phytop...
Glycyrrhizic Acid Alleviates Osimertinib-Induced Cutaneous Toxicity by Inhibiting Keratinocyte Apoptosis and Inflammation [0.03%]
甘草酸通过抑制角质形成细胞凋亡和炎症来缓解奥希替尼诱发的皮肤毒性
Congying Wang,Jiabin Lu,Huangxi Fu et al.
Congying Wang et al.
Osimertinib is a primary treatment for patients with EGFR-mutated non-small cell lung cancer. But a significant number of patients receiving Osimertinib treatment suffer from cutaneous toxicity, which includes symptoms such as rash, itching...
Ying Wang,Zhicheng Liu,Xueru Wang et al.
Ying Wang et al.
Osteoporosis (OP) is a common metabolic bone condition characterized by the breakdown of bone microarchitecture and a reduction in bone mass, which notably heightens the likelihood of fracture, especially among older adults. Currently, ther...
Loganic Acid Ameliorates Rheumatoid Arthritis via the Lactobacillus murinus-Inodole-3-Acetic Acid-AhR-IL-10 Axis [0.03%]
乳酸菌明氨酸-吲哚乙酸-AhR-IL-10轴介导鼠李糖乳杆菌明胶改善类风湿性关节炎中的作用研究
Weiling Tan,Yufang Fu,Wanyu Hu et al.
Weiling Tan et al.
Loganic acid (LA), a major iridoid glycoside from Gentiana macrophylla Pall., possesses anti-inflammatory and immunomodulatory properties, but its therapeutic potential in rheumatoid arthritis (RA) and its interaction with the gut microbiot...
Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation-Energy Axis? [0.03%]
阿尔茨海默病早期缺氧条件下的小胶质细胞活化：天然SIRT1激活剂能成为炎症-能量轴的治疗盟友吗？
Sara Merlo,Cristiana Lucia Rita Lipari,Aurora Patti et al.
Sara Merlo et al.
Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even t...
Astragali radix Against Colorectal Cancer: Network Pharmacology, Molecular Docking, and In Vitro/In Vivo Validation of PI3K-Akt Pathway Modulation [0.03%]
黄芪抗结直肠癌作用研究：基于网络药理学、分子对接及体内外实验验证_PI3K-Akt信号转导途径调控机制
Zhaohuan Li,Jianjin Guo,Mingbin Gui et al.
Zhaohuan Li et al.
Colorectal cancer (CRC) exhibits high incidence and mortality rates, and current therapeutic approaches remain limited, underscoring the urgent need for novel treatment strategies. Astragali Radix, a traditional Chinese medicine with divers...