Z-Guggulsterone Induces Ferroptosis in Chemoresistant Breast Cancer via a CDKN2B-Mediated Suppression of GTP Cyclohydrolase 1 [0.03%]
姜黄素衍生物Z-古鲁糖醇通过CDKN2B介导的二氢叶酸还原酶抑制诱导耐药乳腺癌细胞铁死亡
Zhuo-Tao Yang,Jian-Cheng Mou,Wei-Min Hong et al.
Zhuo-Tao Yang et al.
The development of tumor resistance remains a major challenge in breast cancer therapy, frequently leading to diminished treatment efficacy. Ferroptosis, a recently identified form of programmed cell death, has been associated with various ...
Magnoliae flos Overcomes EGFR-TKI Resistance in NSCLC by Enhancing EGFR Ubiquitination [0.03%]
Magnoliae flos 通过促进EGFR泛素化来克服NSCLC中EGFR-TKI获得性耐药
Qing Wu,Qi Su,Man Zhu et al.
Qing Wu et al.
Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) remains a significant obstacle in treating non-small cell lung cancer (NSCLC). There is an urgent need for novel therapeutic approaches to overcome such...
Pueraria montana var. lobata Root Extract Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Increasing Mitochondrial β-Oxidation and Mitochondrial-Peroxisome Contact [0.03%]
葛根提取物通过增加线粒体β氧化和线粒体-过氧化物酶体接触来改善代谢功能障碍相关脂肪肝疾病
Han-Lin Lu,Der-Yen Lee,Yi-Wen Huang et al.
Han-Lin Lu et al.
Pueraria montana var. lobata (Willd.) is a well-known herbal medicine, also referred to as "kudzu." It is used in traditional Chinese medicine to treat various medical conditions, including diabetes, cardiovascular diseases, diarrhea, and h...
Astragaloside IV Exhibited Antidiabetic Effects by Improving Glucose Metabolism, Repairing Damaged Gut Barrier and Regulating Intestinal Microbiota [0.03%]
黄芪IV通过改善葡萄糖代谢、修复受损的肠道屏障和调节肠道菌群发挥其抗糖尿病作用
Xiaolei Yang,Chenyang Zhu,Bei Liu et al.
Xiaolei Yang et al.
Astragaloside IV (AS-IV), a main active ingredient derived from Astragali Radix, displays a favorable effect in treating type 2 diabetes mellitus (T2DM). This study was aimed to figure out its antidiabetic mechanisms. The db/db mice were tr...
A Comprehensive Review on Necroptosis Inducing Phytochemicals for Cancer Therapy: Preclinical Evidence [0.03%]
植物化学物质诱导坏死性凋亡的癌症治疗的综述：前临床证据
Bhuvaneshwari Deivendran,Suryaa Manoharan,Ekambaram Perumal
Bhuvaneshwari Deivendran
Evading programmed cell death, particularly by inhibiting apoptotic pathways, is an iconic feature of cancer. Necroptosis, a controlled type of necrosis, is now recognized as an appealing alternative for overcoming apoptotic resistance and ...
Epigallocatechin-3-Gallate (EGCG) Mitigates Deep Vein Thrombosis Through Antioxidant and Anti-Ferroptotic Actions via the NRF2-NEDD4 Pathway [0.03%]
表没食子儿茶素没食子酸酯通过NRF2-NEDD4通路的抗氧化和抗铁死亡作用缓解深静脉血栓形成
Da Li,Youjun Mao,Xiaosong Zhang et al.
Da Li et al.
Deep vein thrombosis (DVT) is a prevalent vascular disorder associated with high morbidity and mortality. Evidence suggests that ferroptosis plays a critical role in thrombus formation. Epigallocatechin-3-gallate (EGCG), the primary bioacti...
Hesperidin Promotes Peripheral Nerve Repair by Inducing Autophagy and Inhibiting Apoptosis via the STAT3/Bcl-2 Pathway [0.03%]
柚皮素通过STAT3/Bcl-2信号通路诱导自噬和抑制凋亡促进周围神经修复
Yixin Bo,Dongbo Tian,Yangfan Guo et al.
Yixin Bo et al.
This study explores the therapeutic potential and mechanisms of Hesperidin, a natural flavonoid, in promoting peripheral nerve injury (PNI) repair. We focused on its regulation of autophagy and apoptosis, and examined whether these effects ...
Safety of 8-Week Administration With Ashwagandha (Withania somnifera) Root Extract in Adults With Stress and Anxiety: Findings From a Prospective, Randomized, Multi-Center, Double-Blinded, Placebo-Controlled Study [0.03%]
一项前瞻性、随机、多中心、双盲、安慰剂对照研究发现：八周使用阿育吠陀补品印度ewithania somnifera）根提取物对压力和焦虑成人受试者安全性良好
Ketan Pakhale,Jaising Salve,John Ademola et al.
Ketan Pakhale et al.
Ashwagandha (Withania somnifera) has been recognized for enhancing physical strength, mental well-being, and overall vitality. Despite its long-standing use across generations, some clinical reports have noted occasional adverse events. Thi...
Eriodictyol Regulates Macrophage Polarization to Treat Rheumatoid Arthritis by Inhibiting Jumonji Domain-Containing Protein D3-Mediated Demethylation of Trimethylation of Lysine 27 on Histone H3: An Integrative Single Cell Sequencing and Experimental Validation Study [0.03%]
通过抑制JmjD3介导的组蛋白H3赖氨酸27三甲基化脱甲基化治疗类风湿关节炎的木犀草素调节巨噬细胞极化的整合单细胞测序和实验验证研究
Zixuan Li,Huan Pei,Yuhang Nie et al.
Zixuan Li et al.
Eriodictyol (EDT), a natural flavonoid abundant in citrus fruits, exhibits potent anti-inflammatory activity. However, its therapeutic potential and mechanisms of action in rheumatoid arthritis (RA) remain poorly understood. This study aime...
Phytochemicals Targeting Wnt/β-Catenin in Osteoblasts: Mechanisms, Scaffolds, and Computational Insights for Bone Therapeutics [0.03%]
植物化学物质靶向成骨细胞中的Wnt/β-连环蛋白：机制、骨架和计算见解在骨治疗中的应用
Aarti Abhishek Shah,Anupam Goswami,Kapil Dev et al.
Aarti Abhishek Shah et al.
The Wnt/β-catenin signaling pathway is pivotal for osteoblast differentiation, bone formation, and skeletal homeostasis, with its dysregulation linked to osteoporosis and fracture non-union. Phytochemicals offer promising alternatives to u...