Curcumin Induces Macrophages Polarization to Alleviate Ulcerative Colitis by Regulating Macrophage Nuclear Morphology via Affecting the Interaction Between Enteric Glial Cells Glial-Derived Neurotrophic Factor and Casein Kinase 2 [0.03%]
姜黄素通过调节肠胶质细胞系源性神经营养因子与蛋白激酶CK2之间的相互作用改变巨噬核形态诱导巨噬极化从而缓解溃疡性结肠炎
Huixia Zhang,Mengge Ren,Qi An et al.
Huixia Zhang et al.
Macrophages exhibit dynamic functional phenotype shifts under diverse influences, releasing either anti-inflammatory or pro-inflammatory cytokines and playing a pivotal role in ulcerative colitis (UC) pathogenesis. In recent years, the role...
Natural Modulators of the TP53 Pathway: Potential Herbal and Plant-Derived Agents for Cancer Therapy [0.03%]
天然的TP53通路调节剂：癌症治疗中的潜在草药和植物来源制剂
Sudeshna Nandi,Arghya Naskar,Somanjana Khatua et al.
Sudeshna Nandi et al.
The transcription factor p53, often called the "guardian of the genome," is critical for preserving genomic integrity. Mutations in the TP53 gene are found in approximately half of all human malignancies, including breast, colon, lung, live...
Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera) [0.03%]
Ashwagandha（Withania somnifera）水提取物的安全性评估
Mukesh Summan,Candace L Doepker,Gregory P Brorby
Mukesh Summan
Consumer interest in botanicals as part of their diet continues to grow with many options being offered, but the public health requirement for an understanding of potential toxicity underscores the need for safety data to be developed speci...
Research Progress of Natural Compounds in the Treatment of Diabetes and Its Complications [0.03%]
天然化合物治疗糖尿病及其并发症的研究进展
Ying-Rui Wang,Zheng Liu
Ying-Rui Wang
Diabetes mellitus (DM) is a global metabolic disorder characterized by disturbed glucose and lipid metabolism and persistent hyperglycemia. Commonly used clinical hypoglycemic agents are associated with side effects such as gastrointestinal...
Efficacy of Plant-Derived Therapies for Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [0.03%]
植物衍生疗法治疗原发性痛经的疗效：随机对照试验的系统评价和 meta 分析
Lifei Wu,Inmaculada Xu Lou,Zhenting Hu et al.
Lifei Wu et al.
Primary dysmenorrhea is defined as recurrent, cramp-like lower abdominal pain occurring during menstruation in the absence of underlying pelvic pathology. A significant proportion of the population opts for natural plant-based remedies due ...
Phenethyl Isothiocyanate Suppresses Hepatocellular Carcinoma Progression and Immune Evasion via ZNF652 Regulation of PD-L1 [0.03%]
异硫氰酸苯乙酯通过ZNF652调节PD-L1抑制肝细胞癌进展和免疫逃逸
Dongxue Ren,Jinyi Wu,Jiayu Zhu et al.
Dongxue Ren et al.
The therapeutic efficacy of immune checkpoint inhibitors in hepatocellular carcinoma (HCC) remains limited, with programmed death receptor-1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) blockade effective in only some patients. Here, we ...
Rutaecarpine Attenuates Hepatic Lipid Accumulation and Oxidative Stress by Activating Autophagy Through the AMPK/ULK1 Pathway [0.03%]
rutaecarpine通过AMPK / ULK1途径激活自噬来缓解肝脂质蓄积和氧化应激
Meiyu Jin,Hao Yu,Mengfan Lv et al.
Meiyu Jin et al.
Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder disease in modern society, primarily caused by abnormal fat accumulation in the liver. This study aims to uncover the effects and potential mechanisms by which Ruta...
Saikosaponin D Alleviates Liver Ischemia-Reperfusion Injury by Inhibiting Mitophagy-Associated Ferroptosis via the STAT3/PINK1 Pathway [0.03%]
飞蛇皂苷D通过STAT3/PINK1信号通路抑制线粒体自噬相关铁死亡从而缓解肝脏缺血再灌注损伤
Xingyun Liu,Yaru Xu,Xiaolan Yu et al.
Xingyun Liu et al.
Liver ischemia-reperfusion injury (LIRI) may cause severe complications in liver surgery, primarily involving damage to hepatocytes and endothelial cells, as well as an inflammatory response from immune cells. Saikosaponin D, a plant widely...
Apigenin Inhibits Triple-Negative Breast Cancer Growth by Dual Targeting GPX4/SLC7A11-Mediated Ferroptosis and PKM2/GLUT1-Mediated Aerobic Glycolysis [0.03%]
阿皮金抑制三阴性乳腺癌生长的作用机制研究：通过GPX4/SLC7A11介导的铁死亡和PKM2/GLUT1介导的糖酵解双重靶向作用
Mingmei Zhu,Danping Peng,Zhongyang Yu et al.
Mingmei Zhu et al.
Triple-negative breast cancer (TNBC) is aggressive with limited treatments. Although the natural flavonoid Apigenin (API) shows anti-tumor potential, its mechanism in TNBC remains unclear. This study investigated API's role in inducing ferr...