Scutellarin Alleviates Hepatic Steatosis by Autophagy-Mediated NCoR1/PPARα-Driven Fatty Acid β-Oxidation and Enhancing Peroxisome Biogenesis [0.03%]
胡核受体共抑制因子1介导的自噬在半边莲黄酮逆转PPARα脂肪酸氧化障碍性肝脂代谢紊乱中的作用及机制研究
Jianmei Zheng,Lu Cheng,Yingmin Wei et al.
Jianmei Zheng et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver disorder with limited treatment and manifests as hepatic lipid accumulation. The reduction of nuclear receptor corepressor 1 (NCoR1) activates the...
Anti-Allergic Potential of Chamaecrista nomame and Its Compound Luteolin for Novel Asthma Therapy [0.03%]
chófa 沙米草黄芩素的抗过敏潜力及其组分芸香素用于新型哮喘治疗的潜在价值
Tae Kyeom Kang,Myungsuk Kim,Tam Thi Le et al.
Tae Kyeom Kang et al.
Asthma is a chronic inflammatory disease driven by dysregulated immune responses and mast cell activation. While corticosteroids remain the primary treatment, their long-term use is associated with adverse effects, necessitating safer alter...
Curcumin Treatment for Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanism Exploration, Clinical Application Strategies, and Application Limitations Challenges [0.03%]
姜黄素治疗代谢功能异常相关脂肪性肝病：机制探索、临床应用策略及应用局限挑战
Siyu Lan,Xinyi Zhou,Yifei Xiang et al.
Siyu Lan et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD), as a liver phenotype of metabolic syndrome, has a global prevalence of up to 32.4%. Its pathogenesis involves complex pathological networks, including lipid metabolism disord...
Biologically Active Ingredients and Underlying Mechanisms of Cordyceps in Treating Respiratory Diseases: A Comprehensive Review With Future Perspectives [0.03%]
冬虫夏草活性成分及其治疗呼吸系统疾病作用机制的综述与展望
Wen Zhang,Yuqi Zong,Xiao Huang et al.
Wen Zhang et al.
The incidence of respiratory diseases is increasing worldwide and imposes a significant health burden. Due to the complex etiology and diverse inducements of these diseases, existing therapies often struggle to control disease progression a...
Flavokawain A Targets CXCR4-Mediated Vasculogenic Mimicry to Reverse Hepatocellular Carcinoma Resistance to Tyrosine Kinase Inhibitors [0.03%]
flavokawain A靶向CXCR4介导的血管生成模仿逆转肝细胞癌对酪氨酸激酶抑制剂的耐药性
Ning Zheng,Yan Chen,Shijie Luo et al.
Ning Zheng et al.
Tyrosine kinase inhibitors (TKIs), such as sorafenib, lenvatinib, and regorafenib, serve as the mainstay targeted therapies for advanced hepatocellular carcinoma (HCC), yet resistance severely limits their clinical benefits. This study aime...
Mechanisms of Mulberry Leaf Extracts Ameliorating Inflammation and Fibrosis in Non-Alcoholic Fatty Liver Disease Mice via NF-κB and TGFβ1/Smad3 Pathways [0.03%]
桑叶提取物通过NF-κB和TGFβ1/Smad3途径改善非酒精性脂肪肝病小鼠的炎症和纤维化的机制研究
Shunying Li,Lijuan Zhang,Shaoli Fan et al.
Shunying Li et al.
Mulberry leaf, as a traditional Chinese medicinal plant, has been utilized in the treatment of various diseases, including diabetes, cardiovascular diseases, inflammatory disorders, and liver diseases. However, the mechanisms underlying its...
An Updated Overview on Targeting Nrf2 by Natural Compounds Against Doxorubicin-Induced Cardiotoxicity [0.03%]
天然化合物通过激活Nrf2途径防治多柔比星心肌毒性研究进展
Fatemeh Yarmohammadi,Gholamreza Karimi
Fatemeh Yarmohammadi
Doxorubicin (DOX) is an effective and widely used chemotherapeutic agent against various cancers. However, its clinical utility is limited by an irreversible cardiotoxicity. The underlying mechanisms of DOX-induced heart damage are complex ...
Curcumin Alleviates the Osteogenesis Inhibition and the Aging Process in BMSCs Induced by Iron Overload Through Activating the NRF2/GPX4 Pathway [0.03%]
姜黄素通过激活NRF2/GPX4信号通路缓解铁过载诱导的间充质干细胞成骨抑制及衰老过程
Jingmin Che,Qing Feng,Zhixia Zhao et al.
Jingmin Che et al.
Dysregulated proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs) represent a key pathophysiological mechanism in osteoporosis. Recent studies have demonstrated a significant association between ferroptosis and th...
Gypenoside XVII Ameliorates Osteoarthritis and Suppresses Chondrocyte Apoptosis and Extracellular Matrix Degradation via STING-Dependent Inhibition of ER Stress [0.03%]
甘草次酸XVII通过STING依赖的内质网应激抑制作用改善骨关节炎并抑制软骨细胞凋亡和细胞外基质降解
Jinquan Wang,Jingtao Wu,Heng Yu et al.
Jinquan Wang et al.
Excessive activation of endoplasmic reticulum (ER) stress, chondrocyte apoptosis, and extracellular matrix (ECM) degradation are considered critical pathological factors in OA. However, current therapies are not effective enough to mitigate...
(+)-Matairesinol, Derived From Olive Oil, Enhanced T-Cell Anti-Tumor Immune via JAK3-STAT1 Signal and Synergized With Anti-PD-1 Efficacy [0.03%]
橄榄油衍生物（+）马体瑞醇可通过JAK3-STAT1信号增强T细胞的抗肿瘤免疫并协同PD-1抗体疗效
Zhi Dai,Xin-Hui Wang,Miao Xia et al.
Zhi Dai et al.
Extra virgin olive oil (EVOO) is one of the signature foods for cooking and dressing in the Mediterranean diet, and clinical evidence revealed its remarkably lower risk of breast cancer. However, the current anti-tumor constituent studies r...