Fucoxanthin Protects Against Acute Liver Injury by Inhibiting NOD-Like Receptor Protein 3 Inflammasome-Mediated Pyroptosis Through the Mitogen-Activated Protein Kinases and Nuclear Factor-Kappa B Pathway [0.03%]
岩藻黄素通过MAPK和NF-κB信号通路抑制NLRP3炎性小体介导的细胞焦亡从而保护急性肝损伤
Yigang Zheng,Hanglu Ying,Jiayi Shi et al.
Yigang Zheng et al.
Acute liver injury (ALI) is a severe public health problem closely associated with oxidative stress, inflammation, and hepatocyte injury, leading to high mortality. Fucoxanthin (Fx), a marine carotenoid found in brown seaweeds, has various ...
Ginsenoside Rg5 Ameliorates Ferroptosis in Ethanol-Induced Acute Liver Injury by Activating FTO-YTHDF2-Nrf2 Signal [0.03%]
Ginsenoside Rg5通过激活FTO-YTHDF2-Nrf2信号改善酒精诱导的急性肝损伤中的铁死亡
Guan-Yue Shan,Yu-Xin Zhang,Hui Wan et al.
Guan-Yue Shan et al.
Ginseng (Panax ginseng Meyer), one of the most widely known Chinese herbs, has been used in traditional medicine for centuries. Ginsenoside Rg5 (Rg5) can exert protective effects on the liver and activate the Nrf2 pathway. This study aims t...
Mechanism of Cucurbitacin B Targeting ZNF70/NLRP3 Axis Against Inflammation-Associated Colorectal Cancer [0.03%]
cucurbitacin B靶向ZNF70/NLRP3轴抑制炎症相关结直肠癌的作用机制研究
Shen Cao,Yi Tai,Yuhan Wang et al.
Shen Cao et al.
Cucurbitacin B is a naturally occurring tetracyclic triterpenoid extracted from plants in the Cucumis melo L. It demonstrates various pharmacological activities, such as hepatoprotective, anti-inflammatory, and anti-tumor effects. However, ...
Efficacy and Safety of Melaleuca alternifolia (Tea Tree) Oil for Acne-A Systematic Review and Meta-Analysis [0.03%]
茶树（Melaleuca alternifolia）植物油治疗痤疮的疗效和安全性——系统回顾和荟萃分析
Yixin Ye,Jun Jie Lim,Zongxun Huang et al.
Yixin Ye et al.
Acne vulgaris is a common chronic inflammatory skin disorder that begins in adolescents and often persists into adulthood, with substantial psychosocial impact. Tea tree oil (TTO) has been explored as a topical treatment for acne, but clini...
Gentiopicroside Ameliorates Psoriasis-Like Dermatitis by Modulating Immune Homeostasis and Suppressing NF-κB Activation [0.03%]
Gentiproscolidine通过调节免疫稳态和抑制NF-κB活化来改善银屑病样皮炎
Lingyun Du,Xiaoke Zhao,Jingjing Wei et al.
Lingyun Du et al.
Psoriasis is a common chronic immune-mediated inflammatory skin disease that presents significant challenges in clinical management. Gentiopicroside (GPS), a bioactive compound derived from Gentiana scabra, has been reported to possess anti...
Naturally Occurring Coumarins as Promising Antimicrobial Agents: Latest Progress [0.03%]
具有抗菌活性的香豆素类天然产物研究进展
Geni Gako,Ramesh Joga,Annapurna Padaraju et al.
Geni Gako et al.
One of the twenty-first century's most significant threats to human health is the rise of microbial diseases. Infectious diseases are caused mainly by microorganisms, including bacteria, viruses, fungi, and protozoa. These organisms are res...
Fisetin Promotes Autophagy in Osteosarcoma by Activating the ROS/FOXO3 Axis via Oxidative Stress [0.03%]
山柰酚通过氧化应激激活ROS/FOXO3轴促进骨肉瘤自噬
Yujie Hu,Lanyi Wei,Jingjing Meng et al.
Yujie Hu et al.
Osteosarcoma is a malignant bone tumor that occurs in adolescents and for which surgical resection and chemotherapy are the treatments of first choice. However, tumor cell metastasis and the toxic effects of chemotherapeutic agents bring gr...
Curcumin Alleviates Bone Cancer Pain by Inhibiting Satellite Glial Cell Activity via Janus Kinase 1/Signal Transducer and Transcription 3 Pathway Activator [0.03%]
姜黄素通过Janus激酶1/信号转导子和转录激活器抑制卫星胶质细胞活性从而缓解骨癌痛
Xinchao Jiang,Yi Song,Mei Fang et al.
Xinchao Jiang et al.
Curcumin is the main active component of Curcuma longa L and has anti-inflammatory, antitumor, and neuroprotective properties, making it a potential candidate for bone cancer pain management. Network pharmacology, molecular docking, and mol...
The TRIM27/STING Axis Mediates Schisandrin B-Induced Inhibition of Myeloid-Derived Suppressor Cells Accumulation to Potentiate Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma [0.03%]
三七活性成分发挥逆肿瘤免疫抑制作用的分子机制研究
Lei Huang,Siying Li,Ziqing Li et al.
Lei Huang et al.
Hepatocellular carcinoma (HCC) is characterized by a highly immunosuppressive microenvironment, which contributes to its unfavorable clinical outcomes. Myeloid-derived suppressor cells (MDSCs) play a crucial role in this process. Schisandri...
Astragaloside IV Enhances Mitophagy to Alleviate Renal Ischemia/Reperfusion Injury via PINK1/Parkin Pathway [0.03%]
绞股蓝皂苷IV通过PINK1/Parkin通路增强线粒体自噬缓解肾缺血再灌注损伤
Lin Liu,Zonghui Xu,Shujing Wu et al.
Lin Liu et al.
Astragaloside IV (AS-IV), a primary bioactive component of Astragalus membranaceus (AM). It is very effective in regulating renal diseases. However, the possible underlying mechanism of AS-IV on renoprotection remains unclear. The aim of th...