Paeoniflorin Ameliorates Alcohol-Induced Depression via Modulating the Gut-Brain Axis and Inhibiting the NF-κB/NLRP3 Inflammasome Pathway in Mice [0.03%]
芍药苷通过调节肠脑轴并抑制NF-κB/NLRP3炎性小体信号通路改善酒精诱导的小鼠抑郁模型
Jingwei Yu,Ruijing Zhang,Yingshi Quan et al.
Jingwei Yu et al.
Paeoniflorin (PF), the primary bioactive component of Paeonia plants, exhibits neuroprotective and anti-inflammatory activities. However, its potential role in alcohol-induced depression (AID) through the microbiota-metabolite-brain axis re...
Natural Plant Bioactives as Regulators of Histone Modifications: Bridging Epigenetics and Anticancer Therapy [0.03%]
天然植物活性物质作为组蛋白修饰调节剂：表观遗传学与抗癌治疗之间的桥梁
Mengxiao Wang,Junyi Liang,Xinping Zhu et al.
Mengxiao Wang et al.
Cancer remains a leading cause of global mortality, with tumor heterogeneity, recurrence, metastasis, and drug resistance posing significant challenges to conventional therapies, which are often limited by toxicity and efficacy. Epigenetic ...
Berberine Improved the Therapeutic Efficacy of UC-MSCs for DSS-Induced Colitis via Aerobic Glycolysis [0.03%]
番红花素通过有氧糖酵解改善UC-MSCs治疗DSS诱导结肠炎的疗效
Mengye Wu,Cuiping Li,Jianqi Feng et al.
Mengye Wu et al.
The global prevalence of inflammatory bowel disease (IBD) continues increasing, but effective targeted treatments remain elusive. Recently, mesenchymal stem cells (MSCs) have emerged as a promising candidate for IBD treatment, with energy m...
Pomegranate in Cancer Therapy: A Review of Anticancer Potential, Mechanisms and Clinical Challenges in Breast, Colon and Prostate Cancers [0.03%]
癌症治疗中的石榴：乳腺癌、结肠直肠癌和前列腺癌中抗癌潜力、机制及临床挑战的综述研究论文
Dusanka Kitic,Bojana Miladinovic,Milica Randjelovic et al.
Dusanka Kitic et al.
Pomegranate (Punica granatum L.) is a plant that has been used in traditional medicine for centuries and that has gain popularity in recent years as an anticancer dietary supplement. For the purpose of this review, a comprehensive literatur...
Hydroxytyrosol Improves UV-Induced Skin Photoaging via PI3K-AKT/MAPK/JAK-STAT and NF-κB Pathways: Insights From Keratinocytes and In Vivo Validation [0.03%]
hydroxytyrosol通过PI3K-AKT / MAPK / JAK-STAT和NF-κB途径改善紫外线引起的皮肤光老化：来自角质形成细胞的见解和体内验证
Enhui Wang,Yuting Wang,Zijun Xu et al.
Enhui Wang et al.
This study investigated the efficacy of hydroxytyrosol (HT), an active ingredient renowned for its antioxidant and anti-inflammatory properties derived from olive leaves and oil, in mitigating skin photoaging and elucidating its underlying ...
Valentina Citi,Renda Chahna,Francesca Maffei et al.
Valentina Citi et al.
Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron-dependent form of regulated non-ap...
N6-(2-Hydroxyethyl) Adenosine Alleviates Hepatic Steatosis and Insulin Resistance by Inhibiting JunB+ Adipocytes [0.03%]
N6-(2-羟乙基)腺苷通过抑制JunB+脂肪细胞缓解肝脂质沉积和胰岛素抵抗
Keyan Zhang,Mengdie Lu,Yan Yang et al.
Keyan Zhang et al.
N6-(2-hydroxyethyl) adenosine (HEA), the main active component of Cordyceps species, has garnered attention for its multifaceted hypolipidemic and antihyperglycemic activities. However, the influence by which HEA affects the progression of ...
Bakuchiol Ameliorates Glucocorticoid-Induced Osteoporosis by Enhancing Osteoblast Differentiation via Targeting FAT4 to Activate YAP1 [0.03%]
补骨脂素通过靶向FAT4激活YAP1促进成骨细胞分化来改善糖皮质激素诱导的骨质疏松症
Hengjun Wang,Tingting Zhou,Yunchao Zhao et al.
Hengjun Wang et al.
Psoralea corylifolia Linn. exhibits osteogenic effects; however, the mechanism by which its active component Bakuchiol (BAK) alleviates glucocorticoid-induced osteoporosis (GIOP) remains unclear. We aim to investigate BAK's therapeutic effe...
The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut-Lung Axis [0.03%]
多酚在呼吸和肠道健康中的作用：从肠-肺轴的角度看
Jian Kang,YongJun Du,Yanmei Hou et al.
Jian Kang et al.
The gut-lung axis constitutes a dynamic, multidirectional communication platform between the gastrointestinal and respiratory tracts. Its complexity arises from the integrated crosstalk among the microbiota, immune system, and redox homeost...
Plants and Plant-Derived Compounds Mediate Protection Across Diverse Pathological Conditions by Targeting the PANoptosis Pathways [0.03%]
植物及其衍生物通过靶向PANoptosis途径在各种病理条件下介导保护作用
Fatemeh Yarmohammadi,Seyed Shahram Miraghaee,Gholamreza Karimi
Fatemeh Yarmohammadi
PANoptosis is a complex inflammatory programmed cell death pathway that integrates the key mechanistic features of pyroptosis, apoptosis, and necroptosis. It represents a crucial innate immune mechanism for eliminating infected or damaged c...