Isoquercitrin Improves Renal Tubular Epithelial Cell Mitochondrial Dysfunction by Regulating Extracellular Signal-Regulated Kinase/Reactive Oxygen Species Signaling and Connexin 43 Expression in Diabetic Kidney Disease [0.03%]
异檞皮素通过调节细胞外信号调节激酶/反应性氧物种信号传导和缝隙连接蛋白43表达改善糖尿病肾脏疾病肾小管上皮细胞线粒体功能障碍
Qi Wu,Yupeng Tao,Chenchen Sun et al.
Qi Wu et al.
Isoquercitrin (IQ) is a natural flavonoid compound with potent anti-inflammatory and antioxidant effects; its role and mechanism of action in diabetic kidney disease (DKD) are unclear. This study clarified the role of IQ in delaying DKD and...
Syringin Protects Against Doxorubicin-Induced Cardiotoxicity via Apelinr-Dependent Activation of the Nuclear Factor-Erythroid 2-Related Factor 2/Heme Oxygenase-1 Antioxidant Pathway [0.03%]
氧化苦参碱通过血管活素受体依赖的激活核因子E2相关因子2/血红素氧合酶1抗氧化途径对抗多柔比星致心脏毒性
Yujiang Li,Ting Wang,Ming Shen et al.
Yujiang Li et al.
Cardiotoxicity induced by the chemotherapeutic agent Doxorubicin (Dox) is a major clinical challenge, primarily mediated by overwhelming oxidative stress. While Syringin (Syr) is known for its antioxidant potential, its efficacy and mechani...
Dihydrotanshinone I Induces Ferroptosis in Rhabdomyosarcoma by Targeting HSP90AA1/RACK1/AKT Axis [0.03%]
水溶性丹参茋二氢丹参酮I通过靶向HSP90AA1/RACK1/AKT轴诱导横纹肌肉瘤细胞铁死亡
Qiaofang Liao,Jing Hu,Zhengyu Wu et al.
Qiaofang Liao et al.
Rhabdomyosarcoma (RMS) is an aggressive pediatric soft tissue sarcoma with limited treatment options and poor prognosis. Dihydrotanshinone I (DT), a bioactive compound from Danshen, exhibits anti-inflammatory and antitumor properties, but i...
Sulforaphene-Enriched Raphanus sativus L. Seed Extract Promotes Norepinephrine-Induced Thermogenesis and Weight Loss by Modulating the Interplay Between Adipocytes and Immune Cells in Adipose Tissue [0.03%]
硫化物富集的萝卜种子提取物通过调节脂肪组织中脂肪细胞和免疫细胞的相互作用促进肾上腺素诱导的产热和减肥
Gihyun Hur,Tae Kyung Lee,Jong Hun Kim et al.
Gihyun Hur et al.
Adipose tissue (AT) cells, including adipocytes, immune cells, and macrophages, interact in obesity-related metabolic syndromes. Understanding these interactions is important to develop therapeutic agents. Sulforaphene-enriched radish seed ...
Sulforaphane Attenuates PM2.5-Induced Chronic Obstructive Pulmonary Disease by Modulation of Nrf2 Activating and EGFR/PI3K/AKT Signaling [0.03%]
萝卜硫素通过调节Nrf2活化和EGFR/PI3K/AKT信号传导来缓解PM2.5诱导的慢性阻塞性肺疾病
Qi Lin,Xirong Wu,Shiya Wu et al.
Qi Lin et al.
This study aimed to investigate the prophylactic and therapeutic effects of Sulforaphane (SFN) on PM2.5-induced chronic obstructive pulmonary disease (COPD) and to elucidate the underlying mechanisms. A PM2.5-induced COPD rat model was esta...
A Combined Colon Organoid-Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease [0.03%]
结合类器官-感觉神经元模型揭示上皮细胞对摩里灵缓解炎性肠病痛觉的作用
Francesco Margiotta,Elena Lucarini,Alessandra Toti et al.
Francesco Margiotta et al.
Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influen...
Cinnamaldehyde Regulates the EMT Process and Drug Resistance of Gastric Cancer Through FSTL3-Mediated Cytoskeletal Remodeling [0.03%]
肉桂醛通过FSTL3介导的细胞骨架重塑调节胃癌EMT进程和药物耐药性
Shuhong Zeng,Yi Yin,Ying Zhang et al.
Shuhong Zeng et al.
Cinnamaldehyde (CA) is known to possess anti-tumor properties, such as inhibiting proliferation and migration. However, the specific role and molecular mechanism of CA in gastric cancer (GC) remain unclear. This study aimed to elucidate its...
Ginsenoside Suppresses Triple-Negative Breast Cancer Growth and Synergizes With Programmed Cell Death Protein 1 (PD-1) Immunotherapy Through Gut Microbiota and Metabolic Regulation [0.03%]
人参皂苷可抑制三阴性乳腺癌生长并通过肠道微生物群和代谢调节与程序性细胞死亡蛋白1(PD-1)免疫疗法协同作用
Na Luo,Xin Li,Yu Hu et al.
Na Luo et al.
Breast cancer accounts for 30% of all malignancies and ranks second in cancer-related mortality. Triple-negative breast cancer (TNBC) lacks estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) and pr...
Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4 [0.03%]
藤黄素通过靶向和抑制CDK4激活MAPK信号通路从而抑制肝癌进展
Yang Zhou,Jingyun Chi,Yuan Ding et al.
Yang Zhou et al.
Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low-toxicity anti-HCC therapies. Recently, CDK4-targeted inhibitors have shown promise in the treatm...
Efficacy and Safety of Low-Dose Ashwagandha Supplementation on Exercise Endurance: A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial [0.03%]
低剂量印度阿育吠陀补品Ashwagandha粉对运动耐力的影响：随机、双盲、安慰剂对照临床试验
Himanshu Prajapati,Milan Satia,Dhara Shah et al.
Himanshu Prajapati et al.
Ashwagandha (Withania somnifera) is a well-known adaptogen with established roles in stress modulation and physical performance enhancement traditionally. Low dose Ashwagandha (LDA/Ashwa 0.30) is a bioactive-optimized root-only extract stan...