In Vivo Evidence of Human Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 Mediated Disposition of Glycyrrhizin and Its Drug-Drug Interactions in Humanized Mice [0.03%]
甘草酸及其药物相互作用的人源化小鼠模型构建及OATP介导吸收代谢研究的在体证据
Jiajia Dong,Jiajing Zhong,Xiangnan Wang et al.
Jiajia Dong et al.
Organic anion-transporting polypeptide (OATP) transporters have a significant influence on the disposition of drugs, significantly influencing their efficacy and toxicity. Humans express two transporters (OATP1B1 and OATP1B3), while murine ...
Cryptotanshinone Directly Targets MEK1 to Inhibit Migration and Invasion of Breast Cancer Cells Through Down-Regulating ERK/EMT Axis [0.03%]
Cryptotanshinone直接作用于MEK1抑制乳腺癌细胞的迁移和侵袭并下调ERK/上皮间质转化轴心的作用
Min Qian,Xin Liu,Zhuoran Chai et al.
Min Qian et al.
Cryptotanshinone (CPT) exerts inhibitory effects on breast cancers (BC). However, its effect and potential mechanism on breast cancer cell migration and invasion are not well understood. This study aims to investigate the potential mechanis...
Resveratrol Ameliorates Hypertrophic Scar Formation by Regulating ASIC3-Mediated Fibroblast-Macrophage Crosstalk: A Mechanistic Study [0.03%]
白藜芦醇通过调节酸敏感离子通道3介导的成纤维细胞-巨噬细胞串话改善增生性疤痕形成：一种机制研究
Zili Sun,Suzhou Huang,Xingxing Lu et al.
Zili Sun et al.
To elucidate the mechanism by which Resveratrol (Res) ameliorates hypertrophic scar (HS) formation by targeting acid-sensing ion channel 3 (ASIC3) to modulate macrophage-fibroblast (FB) crosstalk. A rabbit-ear HS model was established in vi...
Ginsenoside Rg1, a Natural Lysosomal Enhancer, Alleviates Parkinson's Disease Pathology via Cathepsin D-Dependent Regulation of α-Synuclein Homeostasis [0.03%]
人参皂苷Rg1通过Cathepsin D依赖性调节α-突触核蛋白稳态缓解帕金森病病理学的一种天然溶酶体增强剂
Ya-Nan Fei,Ming-Yang Hao,Jia-Qiang Liu et al.
Ya-Nan Fei et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss and α-synuclein (α-syn) aggregation, often linked to lysosomal dysfunction. Cathepsin D (CTSD), a lysosomal hydrolase essential...
Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase-7 Mediated β-Catenin Signaling [0.03%]
脱氢成本内酯通过抑制蛋白质酪氨酸激酶-7介导的β-连环蛋白信号抑制肝细胞癌
Xiwen Fan,Junhui Li,Yu Qiao et al.
Xiwen Fan et al.
Dehydrocostus lactone (DHL), a sesquiterpene lactone isolated from Aucklandia lappa (Radix Aucklandiae), is a bioactive compound widely used in traditional medicine for its anti-inflammatory and antitumor properties. However, its precise mo...
Correction to "Oleoylethanolamide Ameliorates Motor Dysfunction Through PPARα-Mediates Oligodendrocyte Differentiation and White Matter Integrity After Ischemic Stroke" [0.03%]
关于“油酰乙醇胺通过PPARα介导的少突胶质细胞分化和缺血性卒中后的白质完整性来改善运动功能障碍”的更正通知
Published Erratum
Phytotherapy research : PTR. 2026 Jun 4. DOI:10.1002/ptr.70393 2026
Baicalein Sensitizes Radioresistant BT549 and MCF7-R Breast Cancer Cells by Modulating Rac1 Signaling [0.03%]
黄芩素通过调节Rac1信号增强巴氏抵抗力BT549和MCF7-R乳腺癌细胞对放射线的敏感性
Zitong Zhao,Zhangyun Li,Quanzhou Peng et al.
Zitong Zhao et al.
Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistan...
Marine Algae and Neuroprotection: Unlocking the Therapeutic Potential Against Neurodegenerative Diseases [0.03%]
海洋藻类和神经保护：解锁对抗神经退行性疾病的治疗潜力
Ritika Devi,Pooja Temgire,Puneet Kumar
Ritika Devi
Neurodegenerative diseases (NDDs) are recognized by the World Health Organization as the second leading cause of mortality worldwide, and their prevalence continues to rise at an alarming rate. Current treatment strategies primarily provide...
Preclinical Evaluation of Berry Extracts as a Nutritional Intervention to Alleviate Myocardial Ischemia-Reperfusion Injury and Atherosclerosis Development [0.03%]
基于浆果提取物的心肌缺血/再灌注损伤和动脉粥样硬化发生的营养干预的临床前评估研究
Lydia Symeonidi,Panagiota-Efstathia Nikolaou,Panagiotis Stathopoulos et al.
Lydia Symeonidi et al.
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. While studies suggest that berry fruits offer beneficial effects in CVD prevention, the bioactive compounds within different berries vary, and the ...
Dihydromyricetin Ameliorates Myocardial Ischemia-Reperfusion Injury by Modulating CKLF1-Mediated Cardiomyocyte Pyroptosis [0.03%]
二氢杨梅素通过调节CKLF1介导的心肌细胞焦亡改善心肌缺血再灌注损伤
Yuting Lin,Yang Sun,Jinping Liang et al.
Yuting Lin et al.
Myocardial ischemia-reperfusion injury (MIRI) remains a major clinical challenge due to limited therapeutic options and the risk of complications such as hemorrhage. Dihydromyricetin (DMY), a flavonoid derived from Vine tea, has shown cardi...