Association Between Statins Use and Major Bleeding in Patients Using Direct Oral Anticoagulants for Atrial Fibrillation [0.03%]
他汀类药物的使用与房颤患者口服直接抗凝药相关的重大出血事件的风险关联研究
A de Burgos-González,L Cea-Soriano,C Huerta-Álvarez
A de Burgos-González
Background: Direct oral anticoagulants (DOAC) were developed as an alternative to vitamin K antagonists in the treatment of NVAF. Statins are frequently prescribed drugs for the prevention of atherosclerotic cardiovascula...
Gerard Ompad,Carolyn E Cesta,Jacqueline M Cohen et al.
Gerard Ompad et al.
Purpose: Common data models (CDMs) standardize healthcare data to facilitate reproducible and consistent analyses, supporting decision-making in medicine and vaccine safety and pharmacoepidemiology. Despite their global r...
From Evidence to Impact: Closing the Loop in Pharmacovigilance With Real-World Data [0.03%]
从证据到影响：利用真实世界数据关闭药物流行病学循环中的缺口
Daniel R Morales,Helga Gardarsdottir
Daniel R Morales
Breakpoint Analyses of the Effects of Sedative Use on Length of Stay and Costs in Chronic Disease Hospitalizations [0.03%]
镇静药使用对慢性病住院时间及费用影响的断点分析
Xing Xing,Jia Wu,Jiaqi Qiao et al.
Xing Xing et al.
Background: Sedatives, a class of psychotropic medications widely prescribed to hospitalized patients, offer various therapeutic benefits. However, inappropriate use can result in significant adverse effects. This study a...
Development and Application of an Algorithm for Statin-Induced Myopathy Based on Electronic Health Record-Derived Structured Elements [0.03%]
基于电子健康记录的肌病所致他汀类药物算法的研发及应用
Akinyemi Oni-Orisan,Meng Lu,Jonathan A Peng et al.
Akinyemi Oni-Orisan et al.
Purpose: Considering the non-specific nature of muscle symptoms, studies of statin-induced myopathy (SIM) in electronic health records require accurate algorithms that can reliably identify true statin-causing cases. Prio...
Impact and Effectiveness of COVID-19 mRNA Vaccination Against COVID-19 Hospitalisation in Paediatrics: A Cohort Study Using Two Linked Data Sources in Spain [0.03%]
基于西班牙两个数据链的数据开展的一项队列研究：COVID-19 mRNA疫苗对儿童新冠肺炎住院影响和有效性的研究
Belén Castillo-Cano,Fabio Riefolo,Felipe Villalobos et al.
Belén Castillo-Cano et al.
Purpose: Despite Spain's > 2 million COVID-19 paediatric cases before 2024, few required hospitalisations (8900). We aimed to estimate the effectiveness of two-dose COVID-19 vaccinations against hospitalisation 'with' and...
Secular Trends in the Use of Valproate-Containing Medicines in Women of Childbearing Age in Europe: A Multinational DARWIN EU Network Study [0.03%]
欧洲育龄妇女使用含有丙戊酸的药物的长期趋势：来自DARWIM EU网络的多国研究
Lucía Bellas,Martí Català,Edward Burn et al.
Lucía Bellas et al.
Background: Valproate-containing medicines (VPA) are first-line treatments for epilepsy; however, they pose teratogenic risks, restricting their use in women of childbearing age. We aimed to estimate the secular trends in...
Multicenter Study
Pharmacoepidemiology and drug safety. 2025 Oct;34(10):e70232. DOI:10.1002/pds.70232 2025
Diagnostic Performance of Prostate Cancer Disease-Specific Phenotypes Identified Using Real-World Databases: A Systematic Review [0.03%]
基于真实世界数据库的前列腺癌疾病特异性表型诊断性能的系统评价
Ami Vyas,Shweta Kamat,Sadie Thomas et al.
Ami Vyas et al.
Background: Research using real-world databases (RWD) often requires the development of computable phenotypes based on clinical reasoning-based algorithms or prediction models with validation through a reference standard ...
Mapping Use of High Dose or Long-Term Oral Glucocorticoids and Steroid-Sparing Strategies in Adults With Chronic Conditions: A Rapid Scoping Review of Reviews [0.03%]
成人慢性病患者高剂量或长期口服糖皮质激素使用及激素保留策略应用的快速综述研究映射
Elizabeth Moore,Mohammad Al Sallakh,Olufemi Olajide et al.
Elizabeth Moore et al.
Purpose: Oral glucocorticoids (OGCs) have a broad range of uses and are effective in treating numerous conditions. However, it is commonly acknowledged that OGCs at high doses or over long periods have a burden of toxicit...
Assessing Impact of Concomitant Use of Proton Pump Inhibitors and Clopidogrel on Incidence of Major Adverse Cardiovascular Events: A Retrospective Cohort Study [0.03%]
质子泵抑制剂与氯吡格雷联用对主要心血管事件发生率影响的回顾性队列研究评估
Aljoharah M Algabbani,Sumaya N Almohareb,Adel A Alrwisan
Aljoharah M Algabbani
Purpose: Clopidogrel, an antiplatelet agent used to prevent ischemic events, may interact with proton pump inhibitors (PPIs), especially omeprazole and esomeprazole, and reduce its effectiveness. The evidence surrounding ...