Measuring Exposure to Opioids Using Self-Reported Medication Use Data Versus General Practitioner Prescription Records in the UK Biobank Study [0.03%]
英国生物银行研究中利用自我报告的用药数据和全科医生处方记录来测量阿片类药物接触度
Allison Domingues,Yue Zhai,Marie-Odile Parat et al.
Allison Domingues et al.
Purpose: The ongoing global increase in opioid use necessitates studies examining long-term health impacts. Prospective cohorts frequently rely on self-reported medication use data which may be subject to several types of...
Comparative Study
Pharmacoepidemiology and drug safety. 2025 Dec;34(12):e70280. DOI:10.1002/pds.70280 2025
Dipeptidyl Peptidase 4 Inhibitors: Novel Therapeutic Agents in the Management of Type II Diabetes Mellitus [0.03%]
二肽基肽酶4抑制剂——治疗2型糖尿病的新药
Chinyere Aloke,Oluwasola Abayomi Adelusi,Olalekan Olugbenga Onisuru et al.
Chinyere Aloke et al.
Background: Mounting evidence indicates that Type 2 diabetes mellitus (T2DM) is a public health challenge globally, and its occurrence is anticipated to surge in the forthcoming years. Dipeptidyl peptidase-4 (DPP-4) serve...
Risk of Major Congenital Malformations Associated With First-Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study [0.03%]
基于理赔数据库的孕早期局部抗真菌药物暴露与主要先天畸形关联性的研究
Tadaharu Kunitoki,Takamasa Sakai,Tomofumi Ishikawa et al.
Tadaharu Kunitoki et al.
Purpose: Vulvovaginal candidiasis is highly prevalent among pregnant women, and its treatment is crucial. However, there is a lack of evidence regarding the risks on fetal outcomes associated with the use of antifungal me...
Efficacy and Safety of All Monoclonal Antibodies in Moderate-to-Severe Atopic Dermatitis: A Systematic Review and Network Meta-Analysis [0.03%]
中重度特应性皮炎单克隆抗体疗法的有效性和安全性：系统评价和网络 meta 分析
Wenting Cai,Linlin Fu,Yan Wu et al.
Wenting Cai et al.
Objective: The aim of this study was to compare the efficacy and safety of monoclonal antibodies (mAb) for moderate-to-severe atopic dermatitis (AD). Meth...
High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury [0.03%]
利用自我控制树型扫描统计量进行高通量筛查以识别与重度急性肝损伤住院相关药物
Vincent Lo Re rd,Craig W Newcomb,Dean M Carbonari et al.
Vincent Lo Re rd et al.
Background: Medications associated with acute liver injury (ALI) are primarily identified by case reports. High-throughput screening of real-world data could be leveraged to detect hepatotoxicity signals. ...
Concurrent Alcohol Use and the Relative Risk of Community-Acquired Pneumonia Associated With Anticholinergic and Non-Anticholinergic Neurocognitively Active Medication Receipt: A National Nested Case-Control Study Among US Veterans [0.03%]
同时饮酒与抗胆碱能和非抗胆碱能神经认知药物使用相关的社区获得性肺炎的相对风险：美国退伍军人中的一项全国嵌套病例对照研究
William H Wang,Kristina Crothers,Kathleen M Akgün et al.
William H Wang et al.
Purpose: Anticholinergic medications and alcohol each independently increase the risk of community-acquired pneumonia (CAP). Whether non-anticholinergic neurocognitively active medications also increase risk, and if alcoh...
Cardiovascular Effectiveness of Semaglutide Versus Dulaglutide in Type 2 Diabetes [0.03%]
在2型糖尿病患者中，索马鲁肽与杜拉鲁肽心血管结局的比较研究
Kasper Bonnesen,Uffe Heide-Jørgensen,Diana H Christensen et al.
Kasper Bonnesen et al.
Objective: Randomized clinical trials show that subcutaneous semaglutide is modestly superior to dulaglutide in reducing HbA1c and body weight, but no trial has compared their effectiveness on hard cardiovascular outcomes...
Comparative Study
Pharmacoepidemiology and drug safety. 2025 Dec;34(12):e70276. DOI:10.1002/pds.70276 2025
The Challenges for Pharmacoepidemiologists Identifying Migraine in Electronic Healthcare Data Sources: A Systematic Literature Review [0.03%]
药物流行病学工作者在电子健康数据中识别偏头痛的挑战：系统文献回顾
Joan Forns,Alicia Abellan,Nuria Riera-Guàrdia et al.
Joan Forns et al.
Purpose: Ascertaining migraine in electronic healthcare data is challenging because of likely diagnosis underrecording and treatment with over-the-counter analgesics, which cannot be used as disease proxies. Algorithm-ide...
Trends in Medication Use Among Young Adults and the Covid-19 Pandemic Effect [0.03%]
年轻人的药物使用趋势及新冠疫情的影响
Meital Zur,Avishai M Tsur,Limor Friedensohn et al.
Meital Zur et al.
Introduction: The COVID-19 pandemic caused unprecedented disruptions in healthcare delivery, and changes in medication utilization patterns. While previous studies examined specific therapeutic classes or populations, the...
All Lines Is the Right Approach: Selecting Patient Lines of Therapy for an External Comparator Arm [0.03%]
千线汇聚方得始终——选择外部对照组的治疗线数
Daniel Backenroth,Laura Hester,Stijn Vansteelandt
Daniel Backenroth
Purpose: To identify the best method for selecting index dates when constructing external comparator arms (ECAs) from real-world data for comparison with single-arm trials (SATs). ...