Comparing IPCW Models to Adjust for Informative Censoring During COVID-19 Using Data From the Clinical Practice Research Datalink [0.03%]
使用临床实践研究数据链新冠数据比较IPCW模型以调整信息性截尾现象的影响
Gwen Aubrac,Michael Webster-Clark,Robert W Platt
Gwen Aubrac
Purpose: Observational comparative studies can be analyzed using intention-to-treat (ITT) (i.e., initial-treatment) or as-treated (AT) (i.e., per-protocol) approaches to estimate distinct treatment effects. Unfortunately,...
Comparative Study
Pharmacoepidemiology and drug safety. 2025 Oct;34(10):e70235. DOI:10.1002/pds.70235 2025
Trajectories of Adherence to Biologics in Patients With Inflammatory Bowel Diseases: A Large-Scale Multi-Regional Italian Study Through the VALORE Distributed Database [0.03%]
意大利多地区溃疡性结肠炎患者使用生物制剂依从性的轨迹：VALORE分布式数据库的大规模研究
Sabrina Giometto,Andrea Spini,Giorgia Pellegrini et al.
Sabrina Giometto et al.
This study aimed to identify and describe trajectories of adherence to biologics in patients with IBDs and to identify adherence determinants in the Italian real-world setting. We conducted a retrospective cohort study across 12 Italian reg...
Multicenter Study
Pharmacoepidemiology and drug safety. 2025 Oct;34(10):e70230. DOI:10.1002/pds.70230 2025
Recommendations to Enable Broader Use of Real-World Evidence to Inform Decision-Making Throughout Pharmacovigilance Signal Management [0.03%]
关于扩大真实世界证据的应用范围以全程指导药物警戒信号管理决策的建议
G Niklas Norén,Katherine Donegan,Monica A Muñoz et al.
G Niklas Norén et al.
Introduction: Despite substantial investments in analytical infrastructure and scientific research related to the development and analysis of real-world evidence in support of signal management, the impact on routine phar...
Potential Bias in Self-Controlled Case Series Design: Impact of Incident Versus Prevalent Scenarios of Exposure and Outcome [0.03%]
基于病例系列设计的潜在偏倚：暴露和结果的病列与现患情况的影响
Kyungyeon Jung,Seong Jun Byun,Gyeongmin Lim et al.
Kyungyeon Jung et al.
Purpose: To assess changes in study results in self-controlled case series (SCCS) studies and explore potential biases when applying incident and prevalent exposure and outcome scenarios. ...
Psychiatric Medication Adherence in the United States Before and During the COVID-19 Pandemic [0.03%]
美国新冠疫情暴发前后的精神疾病药物依从性变化情况
Rebecca C Rossom,Hsueh-Han Yeh,Robert B Penfold et al.
Rebecca C Rossom et al.
Objective: The COVID-19 pandemic caused disruptions in in-person mental health (MH) care and a rapid uptake of virtual MH care, but there is little research on the impacts of this on patients' ability to continue their MH...
Comment on "Association of Quinolone Exposure in the First Trimester of Pregnancy and the Risk of Major Congenital Malformations: A Health Administrative Database Study in Japan" by Morishita K. Et Al [0.03%]
关于Morishita K等人的论文“日本健康行政数据库研究：妊娠早期暴露于喹诺酮与主要先天性畸形风险的相关性”的评论
Mesut Gungor,Cagri Caglayan Kuragi,Deniz Ceyda Karagulle et al.
Mesut Gungor et al.
Documentation of Compounded GLP-1 Receptor Agonists in a Large Primary Care Dataset [0.03%]
大型初级保健数据库中复合GLP-1受体激动剂的用药记录
Nathaniel Hendrix,Esther E Velásquez,Harry Pham et al.
Nathaniel Hendrix et al.
Purpose: Large telehealth companies and smaller aesthetic medicine providers used compounded semaglutide and tirzepatide to meet consumer demand for these drugs during their shortages. In this study, we estimate the docum...
Warfarin-Associated Bleeding and Thromboembolic Events in Sub-Saharan Africa: A Systematic Review and Meta-Analysis [0.03%]
华法林在非洲撒哈拉以南地区出血和血栓事件的发生率：系统回顾和 meta 分析
Desalegn Getnet Demsie,Zenaw Debasu Addisu,Chernet Tafere et al.
Desalegn Getnet Demsie et al.
Background: Warfarin use in Sub-Saharan Africa is associated with elevated risks of thromboembolic events and bleeding, but precise prevalence estimates are lacking. This systematic review and meta-analysis aimed to quant...
Quantification of Information Gained by Linking Claims Data to an Electronic Health Record Cohort of Patients With Metastatic Breast Cancer [0.03%]
定量分析链接药物理赔数据与转移性乳腺癌患者电子健康记录队列所获得的信息
Jonah Geddes,Julie Katz,Alex Asiimwe et al.
Jonah Geddes et al.
Purpose: Linking claims data to electronic health record (EHR) data can improve completeness, often at a cost of decreased sample size. Quantifying information gained and differences in patient characteristics between EHR...