Prenatal Exposure to Modafinil and the Risk of Major Congenital Anomalies and Other Adverse Neonatal and Pediatric Outcomes [0.03%]
莫达非尼的宫内暴露与重大先天畸形及其他不良新生儿和儿科结局的风险关系研究
Melinda Kanoun,Naïm Bouazza,Jean-Marc Treluyer et al.
Melinda Kanoun et al.
Objective: To assess the risk of major congenital anomalies (MCAs) and other adverse outcomes following prenatal exposure to modafinil. Methods: ...
Pharmacological Therapy in Patients With Gender Dysphoria: A Cohort Study in the Lazio Region, Italy [0.03%]
性别烦躁患者的药理治疗：意大利拉齐奥地区的一项队列研究
Valeria Belleudi,Sara Lopes,Michela Servadio et al.
Valeria Belleudi et al.
Purpose: Individuals with gender dysphoria (GD) experience discomfort or distress related to gender incongruence. Management often requires pharmacological support for hormonal and psychological needs. This study aimed to...
Jesper Hallas,Hanin Harbi,Thomas Delvin et al.
Jesper Hallas et al.
Pharmacovigilance should expand beyond adverse drug reactions.A concept, Drug Utilization Vigilance (DU‐vigilance), is proposed as an approach to detect unsuspected prescribing or utilization problems.DU‐vigilance relies on analyses of la...
Real-World Data for Safety Studies: Challenges and Opportunities From the Italian Multiple Sclerosis and Related Disorders Register [0.03%]
真实世界数据在安全研究中的挑战与机遇——来自意大利多发性硬化及相关疾病注册中心的视角
Marco Salivetto,Tommaso Guerra,Pasquale Paletta et al.
Marco Salivetto et al.
Introduction: Information on the safety profile of disease-modifying therapies (DMTs) in multiple sclerosis (MS) is often lacking in routine clinical practice. Real-world data sources, such as patient registries, support ...
Comment on 'Comparative Effectiveness and Safety of Three Oral Antihypertensive Therapies on Maternal and Infant Outcomes in a California Medicaid Population, 2016-2020' [0.03%]
关于“加州医疗补助人口中三种口服降压药在2016-2020年对母婴结局的有效性和安全性比较”一文的述评
Maajid Mohi Ud Din Malik,Rajesh Prasad Jayaswal
Maajid Mohi Ud Din Malik
Active Safety Surveillance Using Real-World Evidence (ASSURE) Implementation: Transparent and Reproducible Real-World Evidence Standardized Framework to Support Safety Signal Evaluation [0.03%]
基于真实世界证据的主动安全监测（ASSURE）实施：支持安全性信号评估的真实世界证据透明和可重复标准框架
Kevin Haynes,Jenna Reps,Jill Hardin et al.
Kevin Haynes et al.
Purpose: To summarize experience with Johnson & Johnson's novel Active Safety Surveillance Using Real-world Evidence (ASSURE) program for producing efficient, transparent, applicable, and impactful RWE to support routine ...
A Pharmaco-Epidemiological Research Program Leveraging a Nationwide Database of Kidney Transplantation [0.03%]
基于全国肾脏移植数据库的药物流行病学研究项目
Pierre Marquet,Antoine Humeau,Sabrina Crépin et al.
Pierre Marquet et al.
Objectives: The pharmaco-epidemiological research program in kidney transplantation (PERP-KT) aims to evaluate, for the principal maintenance immunosuppressive drugs (MISDs): the influence of model-informed precision dosi...
Drug-Drug Interaction Signals for Major Bleeding in Nursing Home Residents: High-Throughput Screening of Clopidogrel and Oral Anticoagulants [0.03%]
抗凝血药和氯吡格雷与其他药物相互作用导致出血的信号：护理机构居民中大出血的高通量筛选研究
Adam M D&#x;Amico,Melissa R Riester,Charles E Leonard et al.
Adam M D&#x;Amico et al.
Purpose: Nursing home (NH) residents are at high risk for major bleeding and are frequently exposed to complex medication regimens that may increase the likelihood of clinically important drug-drug interactions (DDIs). Ho...
Long-Term Cardiovascular Risks of Anticholinergic Versus Non-Anticholinergic Antidepressants: A Target Trial Emulation With Negative Control Correction [0.03%]
抗胆碱能与非抗胆碱能抗抑郁药长期心血管风险的靶向试验模拟研究及阴性对照校正
Yang Xu,Hong Xu,Jinxin Guo et al.
Yang Xu et al.
Purpose: Antidepressants remain widely prescribed worldwide, and the potential cardiovascular risks associated with their anticholinergic properties are poorly understood. ...
Comparative Study
Pharmacoepidemiology and drug safety. 2026 Jul;35(7):e70434. DOI:10.1002/pds.70434 2026