Debora Iaculli,Steven Ballet
Debora Iaculli
Therapeutic peptides targeted at various diseases are becoming increasingly relevant for the pharmaceutical industry. Several of these drugs were originally designed by mimicking a segment of a protein of interest. As such, protein mimicry ...
JoLynn B Giancola,Aniekan Okon,Yanfeng Li et al.
JoLynn B Giancola et al.
The proteostasis network involves complex protein signaling cascades. The tagging of proteins with ubiquitin is central to the degradation of cellular proteins, but understanding its exact role in processing proteins is complicated by the c...
Antimicrobial and Potent Anti-Biofilm Properties of Rationally Designed α-Helix Antimicrobial Peptides [0.03%]
具有抗菌和强效抑菌膜活性的理性设计α-螺旋抗菌肽
Motasim Ismael,Khayeli Juliah,Madivoli Edwin
Motasim Ismael
The antimicrobial resistance (AMR) crisis represents a significant global threat. Unlike traditional antibiotics, antimicrobial peptides offer a promising pathway because of their primary mechanisms. This study aimed to evaluate and rationa...
In Vivo Evaluation of Pam2Cys-Modified Cancer-Testis Antigens as Potential Self-Adjuvanting Cancer Vaccines [0.03%]
Pam2Cys修饰的癌症睾丸抗原作为潜在的自佐剂型肿瘤疫苗的体内评估
Salwa Aljohani,Alex G Edmonds,Valeria Castelletto et al.
Salwa Aljohani et al.
Peptide-based vaccines, formulated with an appropriate adjuvant, offer a versatile platform for targeted cancer immunotherapy. While adjuvants are usually coadministered for nucleic acid and protein vaccines, synthetic peptide antigens affo...
N- to C-Peptide Synthesis, Arguably the Future for Sustainable Production [0.03%]
从N-到C-肽合成：可持续生产的未来方向？
Kinshuk Ghosh,William D Lubell
Kinshuk Ghosh
A revolution in peptide production arrived from the innovation of carboxylate to amine C- to N-direction solid-phase synthesis. This cornerstone of modern peptide science has enabled multiple academic and industrial applications; however, t...
Antimicrobial Activity of Short Analogues of the Marine Peptide EeCentrocin 1: Synthesis of Lipopeptides and Head-to-Tail Cyclic Peptides and Mechanism of Action Studies [0.03%]
海洋多肽Eecentrocin 1短片段的抗菌活性研究：脂肽和头尾环肽的合成及其作用机制研究
Danijela Simonovic,Hymonti Dey,Natascha Johansen et al.
Danijela Simonovic et al.
We have synthesised a series of 12-residue analogues of a previously reported lead peptide (P6) developed from the heavy chain of the marine peptide EeCentrocin 1, isolated from the sea urchin Echinus esculentus. We optimised the lead pepti...
Efficient Screening of α-Glucosidase Inhibitory Peptides From Seahorse Through the Innovative Joint Technique: De Novo Sequencing and Parallel SPOT Synthesis [0.03%]
通过创新联合技术高效筛选海马α-糖苷酶抑制肽：从头测序和平行SPOT合成
Shengfang Gao,Yimeng Li,Xiaohui Zhang et al.
Shengfang Gao et al.
In this research, de novo sequencing was innovatively combined with parallel SPOT synthesis for the efficient screening of biological peptides from TCM or seafood: seahorse with synergistic antioxidant and α-glucosidase inhibitory activiti...
Canan Durukan,Jannik Faierson,Isabel van der Wal et al.
Canan Durukan et al.
The secondary structure plays a crucial role in the biological activity of peptides. Various strategies have been developed to stabilize particular peptide conformations, including sequence modifications and macrocyclization approaches. Oft...
Hong-Lin Han,Jing-Yun Su,Xiao-Huan Zhao et al.
Hong-Lin Han et al.
Peptide-based therapeutics have gained attention in cancer treatment because of their good specificity, low toxicity, and ability to modulate immune responses. However, challenges such as enzymatic degradation and poor bioavailability limit...
Beyond Efficacy: Ensuring Safety in Peptide Therapeutics through Immunogenicity Assessment [0.03%]
超越效力：通过免疫原性评估确保肽类药物的安全性
Koulla Achilleos,Christos Petrou,Vicky Nicolaidou et al.
Koulla Achilleos et al.
Peptides are gaining remarkable popularity in clinical diagnosis and treatment due to their high selectivity and minimal side effects. Over 11% of all new pharmaceutical chemical entities authorised by the FDA between 2016 and 2024 were syn...