Photocatalytic Diselenide Contraction as a Tool for Site-Selective Isosteric Ubiquitylation [0.03%]
光催化双硒缩合工具用于位点选择性等电子 ubiquitylation反应
Herwig Weissinger,Moritz Urschbach,Luca Ferrari et al.
Herwig Weissinger et al.
Ubiquitylation is a highly conserved post-translational modification (PTM) in eukaryotes, which serves as a critical regulatory mechanism for protein homeostasis, cellular transport, signal transduction pathways, and numerous other function...
Toward a Green SPPS: The Use of an Innovative Mesoporous pDVB Support for Environmentally Friendly Solvents [0.03%]
面向绿色SPPS：用于环保溶剂的创新介孔pDVB支持物的应用
Luana Lastella,Marco Zecca,Paolo Centomo et al.
Luana Lastella et al.
This study explores the use of a novel polymeric mesoporous support (pDVB) for solid-phase peptide synthesis (SPPS), with the aim of improving the efficiency and sustainability of the process. The pDVB support, functionalized with the Fmoc-...
Antimigratory and Antiproliferative Effects of the Brain-Targeted Peptide Conjugate PepH3-vCPP2319 on Triple Negative Breast Cancer Cell Cultures [0.03%]
脑靶向肽偶联物PepH3-vCPP2319对三阴性乳腺癌细胞系的抗迁移和抗增殖作用研究
Catarina Gonçalves,Miguel A R B Castanho,Marco Cavaco et al.
Catarina Gonçalves et al.
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype affecting mostly younger women with a poor 5-year overall survival. It is characterized by a high metastization rate, particularly to the brain, where the blood-bra...
Barbara Biondi,Fernando Formaggio,Claudio Toniolo et al.
Barbara Biondi et al.
The results of an analysis on the presence of π-turns, characterized by an i ← i + 5 C=O···H-N intramolecular hydrogen bond, in the X-ray diffraction structures of peptides are discussed. The survey returned a total of 55 π-turn occur...
Phage Display-Selected Peptides: Research and Clinical Applications in Cancer Imaging [0.03%]
噬菌体展示技术筛选的多肽在癌症影像诊断中的研究及临床应用进展
Atike Nur Cimen,Melis Hazal Porsuk,Ozlem Kutlu et al.
Atike Nur Cimen et al.
Phage display has emerged as a groundbreaking technique for discovering novel biomolecules with significant applications in cancer diagnosis and therapy. This technique employs genetically engineered bacteriophages to display diverse librar...
Structural Modification and Antitumor Activity Study of Peptide Codesane: Discovery of Novel Stapled Peptide Antitumor Agents [0.03%]
结构修饰及环肽Codesane抗肿瘤活性研究：新型环肽抗肿瘤药物的发现
Qingmei Li,Lijuan Qiu,Yong Li
Qingmei Li
The discovery of novel candidate molecules that may transform cancer treatment carries significant clinical implications. Codesane (COD), an 18-amino acid peptide extracted from the wild bee venom of Colletes daviesanus, is categorized as a...
Antibody Labeling With FITC Facilitates Controlled Release From Peptide Hydrogels Bearing Fc-Binding Motifs [0.03%]
FITC抗体标记促进肽水凝胶中FC结合基序的控制释放
Tania L Lopez-Silva,Joel P Schneider
Tania L Lopez-Silva
Controlled release systems can enhance the efficacy of therapeutic antibodies, particularly for subcutaneous delivery where high or frequent doses are needed. Herein, we designed a peptide hydrogel that displays the binding motif HWRGWV, wh...
Identification of Potent Cell Penetrating, Nontoxic Peptides for Inhibiting MDM2-p53 Interactions: Characterization of Anticancer Peptides via Molecular Dynamics Simulations [0.03%]
基于分子动力学模拟的抗MDM2-p53相互作用穿膜多肽的设计与筛选研究
Pradeep Pant,Aman Sehgal,Tushar Gupta et al.
Pradeep Pant et al.
Inhibiting MDM2-p53 interactions is a crucial therapeutic strategy in cancer treatment, as it can restore the tumor suppressor activity of p53 and inhibit tumor progression. Peptide inhibitors have shown promise in targeting this interactio...
Kalpana Kumari,Vivek Prakash,Naveen Kumar et al.
Kalpana Kumari et al.
Peptide-based nanomolecular constructs offer great possibilities for designing catalytic molecular systems mimicking enzymes. In this study, we designed three tripeptide catalysts that can possibly mimic hydrolase enzymes, with the objectiv...
Synthesis of Diastereomerically Pure Cetrorelix Acetate by Using Fmoc Solid-Phase Peptide Synthesis (SPPS) Strategy: A Commercially Viable Approach [0.03%]
使用Fmoc固相肽合成策略制备绝平纯赛特瑞利克斯乙酸盐：一种具有商业可行性的方法
Kiran Aluri,Srinivas Basavoju,Jagadeesh B Rangisetty et al.
Kiran Aluri et al.
In the synthesis of cetrorelix via solid-phase peptide synthesis (SPPS) employing the Fmoc strategy, the racemization of L-arginine and L-serine was effectively minimized to below 0.5%. This reduction was achieved using the coupling agent H...