Interactions of Peptide Amphiphiles With Viruses and Cells Are Enabled by Amorphous Nanostructures [0.03%]
肽两亲分子通过无定形纳米结构与病毒和细胞相互作用
Julia La Roche,Lena Rauch-Wirth,Laura Zimmerman et al.
Julia La Roche et al.
Peptide amphiphiles can form fibrillar and amorphous structures. While fibrillar assemblies have previously been shown to enhance viral infectivity or retroviral transduction for gene delivery, we now elucidate the mechanism behind amorphou...
Modulating Antimicrobial Activity and Structure of the Peptide Esc(1-21) via Site-Specific Isopeptide Bond Formation [0.03%]
通过特定异肽键形成调节肽Esc（1-21）的抗菌活性和结构
Bruno Casciaro,Daniel Ben Hur,Daniela Roversi et al.
Bruno Casciaro et al.
Antimicrobial peptides (AMPs) represent valid alternatives to conventional antibiotics primarily due to their mechanism of action, which consists of cytoplasmic membrane disruption. However, their clinical application is often limited by cy...
Modulation of Antimicrobial Activities of Aib-Based Artificial Amphipathic α-Helical Peptides by Incorporating Histidine Residues [0.03%]
组氨酸残基调节Aib-based人工两性α-螺旋肽的抗菌活性
Ami Koga,Manami Fuchinoue,Kiyohiko Seki et al.
Ami Koga et al.
Cationic antimicrobial peptides (CAMPs) exhibit potent antibacterial activity by disrupting bacterial membranes. We investigated the effect of histidine incorporation on BKBA-20, a designed amphiphilic helical peptide composed of alternatin...
Anamika Sharma,Ashish Kumar,Beatriz G de la Torre et al.
Anamika Sharma et al.
Various approaches to make peptides have been adopted globally owing to their high demand. The three main approaches commonly used for this purpose are solution synthesis, also called classical solution-phase peptide synthesis (CSPS), solid...
Peptide Synthesis Nomenclature [0.03%]
肽合成命名法
Christian F W Becker,Florine Cavelier,Yosuke Demizu et al.
Christian F W Becker et al.
Therapeutic Potential of Stylissatin A and Related Cyclic Peptides From Marine Sponges [0.03%]
来源于海洋海绵的抗肿瘤化合物stylissatin a及其相关环状多肽的治疗潜力
Aaqib Ullah,Farzana Shaheen,Uzma Salar et al.
Aaqib Ullah et al.
Marine sponges are sessile invertebrates found in moderate, arctic, and tropical regions, serving as a valuable reservoir of bioactive compounds, particularly Pro-rich peptides. Among these, cyclic peptides have attracted significant intere...
Chemical Synthesis of Medin via a Removable Aggregation-Suppressing Linker [0.03%]
通过可移除的聚集抑制连接子化学合成Medin蛋白
Matthias De Vleeschouwer,Brajabandhu Pradhan,Frederic Rousseau et al.
Matthias De Vleeschouwer et al.
Medin, a 50-amino acid fragment derived from the protein MFG-E8 (lactadherin), is the most prevalent amyloid found in humans, present in the vasculature of nearly all individuals over the age of 50. Its biological relevance is highlighted b...
Chemical Synthesis of Crustacean Insulin-Like Peptide Using a Novel Method to Prevent Methionine Oxidation During Solid Phase Peptide Synthesis [0.03%]
一种新型方法防止固相肽合成过程中甲硫氨酸氧化的甲壳动物胰岛素样肽化学合成法
Hidekazu Katayama,Naoaki Tsutsui
Hidekazu Katayama
The oxidation of Met residue(s) in peptides and proteins is sometimes found in solid phase peptide synthesis (SPPS). In this study, in order to develop a method to prevent the oxidation of Met during SPPS, various sulfide compounds were add...
Amy Armstrong,Fleur Coburn,Yanyamba Nsereko et al.
Amy Armstrong et al.
Peptide-drug conjugates (PDCs) are advancing as targeted cancer therapies, leveraging lessons from antibody-drug conjugates (ADCs) to improve tumour specificity. These molecules combine a homing peptide with a cytotoxic payload via a linker...
Influence of Buffering Capacity, pH, and Temperature on the Stability of Semaglutide: A Preformulation Study [0.03%]
缓冲容量、pH值和温度对索马鲁肽稳定性的影响：预制剂研究
Adarsh Malgave,Sideequl Akbar,Ayushi Tiwari et al.
Adarsh Malgave et al.
Therapeutic peptides' physical and chemical stability is of significant interest to the pharmaceutical industry. This study examines the effects of pH, temperature, and buffer strength on semaglutide (SEMA) stability using two orthogonal st...