Peptide Tags for Site-Selective Nonenzymatic Covalent Modification of Proteins [0.03%]
用于蛋白质非酶共价修饰的肽标签以位点选择方式进行蛋白质非酶共价修饰的肽标签
Delphine Nørgaard Møller,Christian Kofoed,Mikkel Boas Thygesen et al.
Delphine Nørgaard Møller et al.
Bioconjugation chemistry is an important tool for studying proteins, developing pharmaceutical agents, and for many other applications. Conventional methods for protein functionalization rely on chemoselective reactions but often have poor ...
Antimicrobial Peptide Moricin Inhibits Streptococcus pneumoniae Growth Through Membrane Disruption: Insights From In Silico and In Vitro Studies [0.03%]
抗菌肽Moricin通过破坏细胞膜抑制肺炎链球菌的生长——基于计算机模拟和体外实验的见解
Imran Ahmad,Shayan Mohd,Afsana Begum et al.
Imran Ahmad et al.
The rise of multidrug-resistant Streptococcus pneumoniae poses a major public health threat, necessitating novel therapeutic targets. Pneumococcal Surface Adhesin A (PsaA), a conserved surface lipoprotein, plays a key role in manganese acqu...
Plant Hormone Cytokinin as Aggregation Modulator of Gelsolin Amyloidosis [0.03%]
植物激素激动素作为凝集素蛋白变性调节物抑制胶体蛋白淀粉样变性聚集的作用机制研究
Dev Seneviratne,Naomi Stock,Tyra Lewis et al.
Dev Seneviratne et al.
Amyloidosis, a self-assembly of proteins or peptides, is associated with numerous degenerative diseases, such as gelsolin amyloidosis, which remain without a cure. Gelsolin protein is an actin-binding protein, but when aggregated in a disea...
Discovery of a Thrombin-Targeting Anticoagulant Peptide From Whitmania pigra via a "Computation-Guided Experimentation" Strategy [0.03%]
通过“计算指导实验”策略从福寿螺中发现一种新型抗凝血肽
Yu-Tong Hua,Rui-Juan Dong,Yin Li et al.
Yu-Tong Hua et al.
Targeting thrombin to screen safe thrombin inhibitors from natural plants and animals is a critical direction in anticoagulant drug development. This study aimed to screen thrombin inhibitors from the nonbloodsucking leech Whitmania pigra (...
Amphipathic Octenyl-Alanine Modified Peptides Mediate Effective siRNA Delivery [0.03%]
两亲性的辛烯基-丙氨酰化多肽有效递送siRNA分子
Tõnis Lehto,Marit Isakannu,Helena Sork et al.
Tõnis Lehto et al.
The development of therapeutic small interfering RNAs (siRNAs) has lately gained significant momentum due to their ability to silence genes in a highly specific manner. The main obstacle withholding the wider translation of siRNA-based drug...
Leveraging the Therapeutic Potential of Natural Peptide Panurgines: Hydrocarbon Stapling Strategy Enhances Their Efficacy Against Breast Cancer [0.03%]
利用天然肽泛乌灵的治疗潜力：疏水 stapled 战略增强其对抗乳腺癌的功效
Zhongzhong Peng,Lei Chen,Xianyuan Miao et al.
Zhongzhong Peng et al.
The development of novel candidate molecules for breast cancer treatment holds significant clinical value. Panurgines (PNG), derived from the venom of the wild bee Panurgus calcaratus, are particularly noteworthy for their anti-breast cance...
DiPTH-Cystine and PTH-Cysteine in Disulfide Bond Analysis Using Automated Edman Degradation [0.03%]
利用程序化Edman降解法测定二硫键中的DiPTH-半胱氨酸和PTH- cystine残留基
Toni Kühl,Yomnah Y Elsayed,Alexander Terekhov et al.
Toni Kühl et al.
The annotation of disulfide bridges in peptides and proteins can be an elaborate process and requires careful revision of multiple data sets to avoid wrong assignment in the structural analysis. Herein, we provide additional support to eluc...
Discovery of Antioxidant Peptide Against Keap1 From Silkworm Protein Based on In Silico Study and In Vitro Antioxidant Activity Detection [0.03%]
基于计算机模拟研究和体外抗氧化活性检测的家蚕蛋白抗Keap1抗氧化肽的发现
Shuoliang Ye,Mengyue Qi,Jianhua Wang et al.
Shuoliang Ye et al.
Nrf2-Keap1 is an important defense system against oxidative stress damage and enhances the body's antioxidant capacity. Targeting the Keap1-Nrf2 signaling pathway and activating Nrf2 has become an effective strategy for treating oxidative s...
Nonsikelelo Nkwanyana,Ashish Kumar,Amit Chakraborty et al.
Nonsikelelo Nkwanyana et al.
Non-swelling silica-based resin was used for peptide synthesis. The strategy used is similar to that of solid-phase peptide synthesis (SPPS), referred to as silica-assisted solid-phase peptide synthesis (SiPPS). A 2-h coupling seemed to fav...
Assessment of Thermal and Photolytic Stress Effects on the Stability of Primary Structure of Synthetic Liraglutide Using LC-HRMS/MS [0.03%]
采用LC-HRMS/MS评估热应力和光降解对合成利拉鲁肽主链稳定性的影响
Devendra Badgujar,Sanket Bawake,V K Yuvaraaj et al.
Devendra Badgujar et al.
Liraglutide (LGT), a synthetic glucagon-like peptide-1 (GLP-1) analogue, is widely used in the treatment of Type 2 diabetes and obesity. Due to its peptide-based nature, it is prone to degradation, particularly under improper storage or han...