On-Resin Pictet-Spengler Cyclization for 1,2,3,4-Tetrahydro-β-carboline-3-carboxylate (Tcc) Peptide Synthesis With Acid-Labile Functional Tolerance [0.03%]
具有酸不稳定的官能团耐受性的树脂固定化Pictet-Spengler环化用于1,2,3,4-四氢-β-色满-3-羧酸肽的合成
Omer S L N&#x;dri,Charity D Yongo-Luwawa,Xiaozheng Wei et al.
Omer S L N&#x;dri et al.
The constrained tryptophan (Trp) analog 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (Tcc) is used to restrict peptide conformation in structure-activity relationship studies. Although Pictet-Spengler cyclization of Trp and aldehydes w...
Antiproliferative Activity of the New Analogues of Acridine/Acridone With Oligopeptide Derivatives and Molecular Docking With EGFR and Src Kinase [0.03%]
新型杂环芳烃/杂环稠合芳烃与寡肽衍生物类似物的抗增殖活性及其与EGFR和Src激酶分子对接研究
Monika Gensicka-Kowalewska,Krystyna Dzierzbicka,Maria Skrzypkowska et al.
Monika Gensicka-Kowalewska et al.
The aim of our work was to analyze new functionalized analogues of 1-nitroacridine/4-methyl-1-nitroacridine and 4-nitroacridone connected to tuftsin/retro-tuftsin derivatives as a potential anticancer therapeutics. Using the MTT assay, we h...
Side Reaction Analysis in Solid-Phase Peptide Synthesis: A Case Study in the Glu-Asp-Tyr Motif [0.03%]
固相肽合成中的侧反应分析：Glu-Asp-Tyr基序的案例研究
Alessandra Monti,Andrea Caporale,Menotti Ruvo et al.
Alessandra Monti et al.
Peptides are important tools in biological, medical, and pharmaceutical research. Solid-phase peptide synthesis (SPPS) is the primary method for their preparation in high yields and purity. However, SPPS often encounters difficulties due to...
Rational Design, Synthesis, and Aphicidal Activity of Novel Insect Short Neuropeptide Analogs as Potential Aphid Control Agents [0.03%]
新型昆虫短神经肽类似物的理性设计、合成及蚜虫毒性作用研究
Yuanlin Zhou,Chunyue Wang,Xiaoli An et al.
Yuanlin Zhou et al.
Short neuropeptide F (sNPF) is a peptide unique to insects, characterized by a C-terminal phenylalanine and a conserved RLRFa motif, and plays key roles in controlling feeding behavior, growth, circadian rhythms, and water-salt homeostasis....
Priyanka Ray Choudhury,Sai Kumar Mishra,Siddharth Yadav et al.
Priyanka Ray Choudhury et al.
Peptides play essential roles in biological systems and serve as key agents in therapeutics, biomaterials, and drug delivery. Despite their broad utility, peptide design is limited by rapid degradation, low oral bioavailability, and the ine...
Estimation of Minimum Diversity to Be Prepared in Random Peptide Libraries for Target-Binding Peptide Discovery [0.03%]
随机肽库中备择多样的最低估计以发现与靶结合的肽分子
Takaaki Hatanaka,Minoru Hirano
Takaaki Hatanaka
Molecular library display systems utilizing phage, bacteria, and genetic material are powerful tools for identifying target-specific peptides. Libraries of sufficient diversity are required to isolate target-specific peptides. Although the ...
Proteomic Analysis Reveals Proteins, Siderophores, and Exopolysaccharides Involved in Cd(II) Stress Response of the Heavy Metal-Tolerant Delftia lacustris B11CM Strain [0.03%]
蛋白质组分析揭示了重金属耐受菌湖德夫特氏菌B11CM株对镉胁迫响应的参与蛋白、铁载体和胞外多糖
Jefferson Beltrán,Juan Sebastian Gualtero,Maryeimy Varón-López et al.
Jefferson Beltrán et al.
Heavy metal (HM) pollution, such as cadmium, significantly impacts ecosystems and poses serious risks to human health. In soil, it reduces fertility and agricultural productivity. On the other hand, bacteria employ several tolerance mechani...
The Significance of Oligomer C-Terminus Design in Solid-Phase Synthesis of Peptide Nucleic Acid Tetramers With the Incorporation of γ-S-Monomer Units Based on L-Glu [0.03%]
基于L-谷氨酸的γ-S单体单元固相合成肽核酸四聚体中寡聚C端设计的意义
Anna A Esenina,Ivan A Prohorov,Viacheslav V Severov et al.
Anna A Esenina et al.
Peptide nucleic acids (PNAs) containing γ-S-modified monomers show promise for antisense applications but face synthetic challenges due to their charged backbone. This study aimed to optimize the Boc solid-phase synthesis protocol for L-Gl...
Annelie Puhlmann,Cihan Baydaroglu,Boris Schade et al.
Annelie Puhlmann et al.
Mucus is the biological hydrogel that lines the mucosal surfaces of mammals and acts as a protective barrier. Its main proteinaceous component is mucin, the high molecular weight, degree of glycosylation, and hardly uniquely defined nature ...