Identification and Mechanistic Study of a Novel Keap1-Targeting Antioxidant Peptide From Ulva prolifera Protein [0.03%]
从海藻中鉴定并研究一种新型的Keap1靶向抗氧化肽及其机制研究
Shaohui Zhu,Shanglian Liu,Huashan Yao et al.
Shaohui Zhu et al.
Activating Nrf2 by targeting the Keap1-Nrf2 signaling axis has emerged as a viable therapeutic approach for managing oxidative stress and its associated disorders. This study employed virtual digestion, ADMET profiling, and molecular dockin...
Self-Assembly of Peptides and Biomolecular Systems Into Functional Nanomaterials [0.03%]
肽和生物分子体系自组装成为功能性纳米材料
Malak Fares,Othman Al Musaimi
Malak Fares
Peptide self-assembly represents a versatile and programmable strategy for generating functional nanomaterials with broad biomedical relevance. This review outlines the physicochemical principles governing assembly, highlighting cooperative...
Hydrophobic Tag-Assisted Scalable Synthesis of Trofinetide and Its GPE Analogues [0.03%]
疏水标签辅助大规模合成曲普肽及其GPE类似物
Veeranjaneyulu Avula,Sai Krishna Vangapelly,Yamanappa Mang et al.
Veeranjaneyulu Avula et al.
Trofinetide (H-Gly-α-MePro-Glu-OH), an FDA-approved drug for Rett syndrome, is a modified derivative of the neuroprotective tripeptide glypromate (H-Gly-Pro-Glu-OH; GPE). We report a scalable, high-yielding liquid-phase peptide synthesis (...
Rational Design and Biological Evaluation of Imidazole-Based Tetrapeptides as Antibacterial Leads Against Staphylococcus aureus [0.03%]
基于咪唑的四肽抗菌先导化合物的合理设计和生物学评价对抗金黄色葡萄球菌的影响
Mohammed Sharif Shaik,Vidya Sagar Jerra,Balajee Ramachandran et al.
Mohammed Sharif Shaik et al.
The increasing prevalence of methicillin and vancomycin-resistant Staphylococcus aureus (MRSA/VRSA) necessitates new antibacterial agents. Penicillin-binding protein 2a (PBP2a) plays a crucial role in bacterial cell wall synthesis. In this ...
Arthropod-Derived Antimicrobial Peptides as Potential AMR Therapeutics: A Special Focus on the Lasioglossins [0.03%]
节肢动物来源的抗菌肽作为潜在的抗微生物耐药性疗法：特别关注Lasioglossin类抗菌肽
Atul Kumar,Biswajit Mishra,Eleftherios Mylonakis et al.
Atul Kumar et al.
The global surge in antimicrobial resistance has intensified the search for novel therapeutic strategies that can overcome the limitations of conventional antibiotics. Antimicrobial peptides (AMPs), particularly those derived from arthropod...
Preeclampsia Diagnosis Using β-Hairpin Peptide for ELABELA Detection [0.03%]
用于检测ELABELA的β发夹肽的子痫前期诊断
Behafarid Ghalandari,Jessica Jessica,Qiang Zhang et al.
Behafarid Ghalandari et al.
Preeclampsia (PE) poses risks to mothers and infants, especially in low-resource settings. Diagnosis of PE is difficult due to nonspecific symptoms and limited biomarker screening. ELABELA, a circulating peptide hormone and endogenous ligan...
Fluctuating β-Sheet Secondary Structure in DS119 Explains the Small Effects of Backbone N-Amination on Thermal Stability [0.03%]
DS119中波动的β-折叠二级结构解释了主链N-氨基化对热稳定性的小影响
Yushi Qiao,Syrah K Starnes,Jožica Dolenc et al.
Yushi Qiao et al.
The miniprotein DS119 has been used as a model system to probe the effects of introducing residues with backbone N-amination into a region of parallel β-sheet secondary structure. Derivatives featuring backbone N-methylation have also been...
Influence of Peptide-Based Chelator Sequences on HER2-Targeting Radiopeptide [0.03%]
基于肽的螯合序列对HER2靶向放射性药物的影响
Sonal Gupta,Manoj Kumar,Krishna Mohan Repaka et al.
Sonal Gupta et al.
In our pursuit of developing HER2-targeting radiolabeled peptides for detection and therapy of HER2-positive breast cancer, the previously reported rL-A9 peptide had shown promising potential. In the present work, a different variant of rL-...
From Venom-to-Vial-to-Pill: The Translational Journey of GLP-1 Peptides and the Evolving Landscape of Biopharmaceutics Modeling [0.03%]
从毒液到小瓶到药片：GLP-1肽的转化之旅及生物药剂学建模的演变景观
Muzaffaruddin Ahmed Madny,Aditya Murthy
Muzaffaruddin Ahmed Madny
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become an important therapeutic option for metabolic disorders. Their development, from the early identification of exendin-4 in Gila-monster venom to the creation of long-acting ana...
Oral Peptide Nano-Formulations for Breast Cancer: An Enhancer-Centric, Regulatory-Ready Path to Clinical Translation [0.03%]
乳腺癌口服肽纳米配方：一个以增强剂为中心且符合监管要求的临床转化路径
Dilpreet Singh,Bishal Singh,Pooja A Chawla et al.
Dilpreet Singh et al.
Breast cancer is increasingly managed as a long-term condition, intensifying the need for therapies that are effective, tolerable, and suitable for chronic administration. Peptide-based therapeutics offer high molecular specificity and favo...