BOP-OXy, BOP-OBt, and BOP-OAt: novel organophosphinic coupling reagents useful for solution and solid-phase peptide synthesis [0.03%]
新型含氧磷试剂BOP-OXy、BOP-OBt和BOP-OAt及其在溶液法和固相多肽合成中的应用研究
Ayman El-Faham,Sherine N Khattab,Ramon Subirós-Funosas et al.
Ayman El-Faham et al.
Stand-alone coupling reagents derived from bis(2-oxo-3-oxazolidinyl)phosphorodiamidic chloride show efficient performance in solution and SPPS. In particular, the Oxyma Pure (Luxembourg Biotech., Tel Aviv, Israel) derivative shows the addit...
A novel modified peptide derived from membrane-proximal external region of human immunodeficiency virus type 1 envelope significantly enhances retrovirus infection [0.03%]
一种新型的人免疫缺陷病毒包膜临近外区衍生多肽可显著增强慢病毒的感染率
Lishuang Zhang,Chunlai Jiang,Huayan Zhang et al.
Lishuang Zhang et al.
Efficient gene transfer is a critical goal in retroviral transduction. Several peptides capable of forming amyloid fibrils, such as the 39-residue semen-derived infection-enhancing peptide (SEVI), have demonstrated the ability to boost retr...
Mimicking hemoproteins: a new synthetic metalloenzyme based on a Fe(III)-mesoporphyrin functionalized by two helical decapeptides [0.03%]
血红素蛋白的人工模拟物——基于两个手性十肽修饰铁(III)中孔卟啉的新合成金属酶
Mariano Venanzi,Sabrina Cianfanelli,Antonio Palleschi
Mariano Venanzi
A new metalloenzyme formed by a Fe(III)-mesoporphyrin IX functionalized by two helical decapeptides was synthesized to mimic function and structural features of a hemoprotein active site. Each decapeptide comprises six 2-aminoisobutyric aci...
Mining antimicrobial peptides from small open reading frames in Ciona intestinalis [0.03%]
Ci.intestinalis小型开放阅读框的抗微生物肽挖掘研究
Yongzhong Lu,Yu Zhuang,Jie Liu
Yongzhong Lu
Though being able to encode various kinds of bioactive peptides, small open reading frames (sORFs) are poorly annotated in many genomic data. The present study was conducted to evaluate the potential of sORFs in encoding antimicrobial pepti...
Tidbits for the synthesis of bis(2-sulfanylethyl)amido (SEA) polystyrene resin, SEA peptides and peptide thioesters [0.03%]
用于合成双(2-硫代乙基)胺(polystyrene树脂、肽及半胱氨酸缩酮酯的研究要点
Nathalie Ollivier,Laurent Raibaut,Annick Blanpain et al.
Nathalie Ollivier et al.
Protein total chemical synthesis enables the atom-by-atom control of the protein structure and therefore has a great potential for studying protein function. Native chemical ligation of C-terminal peptide thioesters with N-terminal cysteiny...
Inhibitory effect of short cationic homopeptides against gram-positive bacteria [0.03%]
短阳离子同源肽对革兰氏阳性菌的抑制作用
Fanny Guzmán,Sergio Marshall,Claudia Ojeda et al.
Fanny Guzmán et al.
In the selection or design of antimicrobial peptides, the key role played by cationic amino acids and chain length on the inhibitory potency and specificity is not clear. A fundamental study was conducted using chemically synthesized homope...
Self-assembling organo-peptide bolaphiles with KLK tripeptide head groups display selective antibacterial activity [0.03%]
具有KLK三肽头部结构的有机肽 bola 型分子自主组装体系表现出抗菌选择性活性
Venthan B Naidoo,Marina Rautenbach
Venthan B Naidoo
In keeping with recent efforts to generate compounds for antibiotic and microbicide development, we focused on the creation of non-natural organo-peptide hybrids of antimicrobial peptide amides (KLK(L)n KLK-NH2 ) derived from sapecin B and ...
Covalently attached fatty acyl chains alter the aggregation behavior of an amyloidogenic peptide derived from human β(2)-microglobulin [0.03%]
共价连接的脂肪酰基链能改变人β₂微球蛋白衍生的淀粉状蛋白生成肽的聚集行为
Anoop Rawat,Ramakrishnan Nagaraj
Anoop Rawat
Aggregation of a polypeptide chain into highly ordered amyloid aggregates is a complex process. Various factors, both extrinsic and intrinsic to the polypeptide chain, have been shown to perturb this process, leading to a drastic change in ...
The importance of being kinked: role of Pro residues in the selectivity of the helical antimicrobial peptide P5 [0.03%]
脯氨酸残基在螺旋抗菌肽P5的选择性和重要性中的作用
Sara Bobone,Gianfranco Bocchinfuso,Yoonkyung Park et al.
Sara Bobone et al.
Antimicrobial peptides (AMPs) are promising compounds for developing new antibiotic drugs against drug-resistant bacteria. Many of them kill bacteria by perturbing their membranes but exhibit no significant toxicity towards eukaryotic cells...
An apolipoprotein E mimetic peptide with activities against multidrug-resistant bacteria and immunomodulatory effects [0.03%]
一种针对多重耐药细菌且具有免疫调节作用的载脂蛋白E模拟多肽
Chuan-qing Wang,Chang-sheng Yang,Yi Yang et al.
Chuan-qing Wang et al.
Apolipoprotein E (apoE) mimetic peptides derived from the low-density lipoprotein receptor-binding region of apoE with both activities against multidrug-resistant bacteria and immunomodulatory effects have not previously been reported. We i...