Cyclization of the Analgesic α-Conotoxin Vc1.1 With a Non-Natural Linker: Effects on Structure, Stability, and Bioactivity [0.03%]
环化镇痛药α-石房蛤毒素Vc1.1与非天然连接臂：对结构、稳定性和生物活性的影响
Yuhui Zhang,Han Shen Tae,David J Adams et al.
Yuhui Zhang et al.
α-Conotoxin Vc1.1 is a disulfide-rich peptide and a promising drug candidate for treating neuropathic and chronic pain. Backbone cyclization was applied to enhance its drug-like properties, resulting in improved serum stability and oral bi...
Synthesis and Biological Activity of Ultrashort Antimicrobial Peptides Bearing a Non-Coded Amino Acid [0.03%]
含非蛋白氨基酸的超短抗菌肽的合成及其生物活性研究
Cristina Peggion,Andrea Schivo,Martina Rotondo et al.
Cristina Peggion et al.
Antimicrobial resistance represents a significant global health threat, prompting the exploration of alternative therapeutic strategies. Antimicrobial peptides (AMPs) and lipopeptides are promising candidates due to their unique ability to ...
Synthesis of a Trans-Phakellistatin 21/22 Conformer and Related Alanine Scanning Analogs With Neuroprotective Activity [0.03%]
具有神经保护活性的反式Phakellistatin 21/22类似物及相应的丙氨酸扫描类似物的合成
Iqra Kanwal,Hunain Ali,Farkhanda Mushtaq et al.
Iqra Kanwal et al.
The phakellistatins are a class of cyclic peptide natural products among which phakellistatin 21 and 22 isolated from the marine sponge Stylissa flabelliformis are cyclo(Pro1-Pro2-Met(O)3-Phe4-Glu5-Leu6-Pro7-Pro8-Tyr9-Ile10) epimeric at the...
Penta-ALFA-Tagged Substrates for Self-Labelling Tags Allow Signal Enhancement in Microscopy [0.03%]
五倍增强的ALFA自标记底物可提高显微镜成像信号强度
Souvik Ghosh,Ramona Birke,Ashwin Karthick Natarajan et al.
Souvik Ghosh et al.
Self-labelling proteins like SNAP- and HaloTag have advanced imaging in life sciences by enabling live-cell labeling with fluorophore-conjugated substrates. However, the typical one-fluorophore-per-protein system limits signal intensity. To...
Stephen B H Kent
Stephen B H Kent
This perspective essay will briefly recount fundamental physicochemical properties of the peptide-resin that have led to the almost universal use of stepwise solid phase peptide synthesis (SPPS) for the chemical synthesis of peptides. The e...
No Evidence for Plasma Membrane Potential-Independent Cell Penetrating Peptide Direct Translocation [0.03%]
无证据表明细胞穿透肽的直接转运与质膜电位无关
Ali Hallaj,Francisco Tomas Ribeiro,Christian Widmann
Ali Hallaj
Cell-penetrating peptides (CPPs) are small peptides that can carry bioactive cargoes into cells. CPPs access the cell's cytosol via direct translocation across the plasma membrane. We and others have shown that direct translocation of CPPs ...
Examining Farnesyltransferase Interaction With Cell-Permeable CaaX Peptides and the Role of the CaaX Motif in Biological Activity [0.03%]
研究法尼基转移酶与可穿透细胞的CaaX肽之间的相互作用以及CaaX模式在生物活性中的作用
Merlin Klußmann,Jan Reuter,Christian Werner et al.
Merlin Klußmann et al.
Recently, we presented cell-permeable CaaX peptides as versatile tools to study intracellular prenylation of proteins. These peptides consist of a cell-penetrating peptide (CPP) and a C-terminal CaaX motif derived from Ras proteins and demo...
Maria Leko,Polina Filippova,Karin Rustler et al.
Maria Leko et al.
Peptide hydrazides are widely applied as precursors of peptide thioesters, valuable building blocks for the synthesis of proteins by native chemical ligation. In addition, they can be applied for the selective modification of cargo or carri...
Identification and Characterization of a Novel GAPDH-Derived Antimicrobial Peptide From Jellyfish [0.03%]
从水母中鉴定和特征化一种新型的GAPDH衍生抗菌肽
Jingwen Liu,An Li,Yueyue Li et al.
Jingwen Liu et al.
Marine organisms serve as a rich source of bioactive natural compounds, including antimicrobial agents. Jellyfish, which are ancient marine invertebrates with hundreds of millions of years of evolutionary history, have been in continuous co...
Cancer-Targeting Peptides Functionalized With Polyarginine Enables GRP78-Dependent Cell Uptake and siRNA Delivery Within the DU145 Prostate Cancer Cells [0.03%]
用聚精氨酸功能化的癌症靶向肽能够在DU145前列腺癌细胞内实现依赖于GRP78的细胞吸收和siRNA传递
George Hilan,Grace Daniel,Filiz Collak et al.
George Hilan et al.
This study investigated a peptide-based GRP78-targeting strategy for short-interfering (si) RNA delivery in cancer cells. Synthetic fluorescein-labeled amphiphilic peptides composed of the hydrophobic cell surface (cs) GRP78-targeting and h...