LncRNA-associated competing endogenous RNA network analysis uncovered key lncRNAs involved in temozolomide resistance and tumor recurrence of glioblastoma [0.03%]
长链非编码RNA相关竞争性内源RNA网络分析揭示了胶质母细胞瘤替莫唑胺耐药及肿瘤复发的关键长链非编码RNA
Rojalin Nayak,Bibekanand Mallick
Rojalin Nayak
Temozolomide (TMZ) is a common alkylating chemotherapeutic agent used to treat brain tumors such as glioblastoma multiforme (GBM) and anaplastic astrocytoma. GBM patients develop resistance to this drug, which has an unclear and complicated...
M Vidhya
M Vidhya
Thrombosis, or the formation of blood clots, can lead to serious medical conditions such as stroke, heart attack, and deep vein thrombosis. The purinoreceptor P2Y12 plays a critical role in the thrombotic pathway and is targeted for therapy...
Spectroscopic, quantum chemical investigation and molecular docking studies on N-(2-benzoylamino) phenyl benzamide: A novel SARS-CoV-2 drug [0.03%]
N-(2-苯甲酰胺基)苯基苯胺的光谱、量子化学研究和分子对接研究：一种新型抗SARS-CoV-2药物
S Pushpam,S Christopher Jeyaseelan,R Jesintha Rani et al.
S Pushpam et al.
The present work describes the structural and spectral properties of N-(2-benzoylamino) phenyl benzamide (NBPB). The geometrical parameters of NBPB molecule such as bond lengths, bond angles and dihedral angles are calculated and compared w...
Gossypin mitigates oxidative damage by downregulating the molecular signaling pathway in oleic acid-induced acute lung injury [0.03%]
锦葵素通过下调分子信号通路缓解油酸致急性肺损伤小鼠的氧化应激损伤
Busra Dincer,Irfan Cinar,Huseyin Serkan Erol et al.
Busra Dincer et al.
One of the leading causes of acute lung injury, which is linked to a high death rate, is pulmonary fat embolism. Increases in proinflammatory cytokines and the production of free radicals are related to the pathophysiology of acute lung inj...
Elucidating the significance of molecular interaction between sulphur doped zinc oxide nanoparticles and serum albumin using multispectroscopic approach [0.03%]
使用多光谱法阐明硫掺杂氧化锌纳米颗粒与血清白蛋白分子相互作用的意义
Mallappa Mahanthappa,Mohammed Azharuddin Savanur,Jagadish Ramu et al.
Mallappa Mahanthappa et al.
Ingenious nanomaterials with improved biocompatibility and multifunctional properties are gaining vital significance in biomedical applications, including advanced drug delivery and nanotheranostics. In a biological system, these nanopartic...
Cheminformatics and systems pharmacology approaches to unveil the potential plant bioactives to combat COVID-19 [0.03%]
运用化学信息学和系统药理学方法揭示潜在的植物生物活性成分以抗击COVID-19
Dhivyadharshini Muralitharan,Venkatramanan Varadharajan,Baskar Venkidasamy
Dhivyadharshini Muralitharan
COVID-19 was a global pandemic in the year 2020. Several treatment options failed to cure the disease. Thus, plant-based medicines are becoming a trend nowadays due to their less side effects. Bioactive chemicals from natural sources have b...
β-Lactoglobulin variants as potential carriers of pramoxine: Comprehensive structural and biophysical studies [0.03%]
β-乳球蛋白变异体作为普鲁卡因胺潜在载体的全面结构和生物物理研究
Piotr Bonarek,Dorota Mularczyk,Joanna I Loch et al.
Piotr Bonarek et al.
β-Lactoglobulin (BLG) is a member of the lipocalin family. As other proteins from this group, BLG can be modified to bind specifically compounds of medical interests. The aim of this study was to evaluate the role of two mutations, L39Y an...
Electrochemical sensor based on molecularly imprinted copolymer for selective and simultaneous determination of riboflavin, dopamine, and L-tryptophan [0.03%]
一种基于分子印迹共聚物的电化学传感器 选择性同时检测核黄素、多巴胺和L-色氨酸
Nagham Mahdi,Mahmoud Roushani,Zahra Mirzaei Karazan
Nagham Mahdi
This research shows the exact detection of riboflavin (RF), dopamine (DA), and L-tryptophan (Trp) through molecularly imprinted polymer (MIP) based on the electropolymerization method. MIP was placed on the surface of the glassy carbon elec...
Green synthesis of silver nanoparticles mediated Azadirachta indica extract and study of their characterization, molecular docking, and antibacterial activity [0.03%]
利用Azadirachta indica提取物介导的绿色合成银纳米颗粒及其表征、分子对接和抗菌活性研究
Ashish A Gawai,Amol R Kharat,Shivani S Chorge et al.
Ashish A Gawai et al.
The green production of silver nanoparticles (AgNPs) produces AgNPs with minimum influence on the environment by using plant components such as alkaloids, carbohydrates, lipids, enzymes, flavonoids, terpenoids, and polyphenols as reducing a...
Mechanistic insights into the inhibition of human placental glutathione S-transferase P1-1 by abscisic and gibberellic acids: An integrated experimental and computational study [0.03%]
赤霉酸和脱落酸抑制人胎盘谷胱甘肽S转移酶P1-1的机制研究：实验与计算相结合的研究
Mohammad Abu Zaid,Ozlem Dalmizrak,Kerem Teralı et al.
Mohammad Abu Zaid et al.
The interactions of the classic phytohormones gibberellic acid (gibberellin A3 , GA3 ) and abscisic acid (dormin, ABA), which antagonistically regulate several developmental processes and stress responses in higher plants, with human placen...