Lorenzo Villanueva,Yogesh Saravanan,Mar Eroles et al.
Lorenzo Villanueva et al.
We present a high-speed force microscopy platform mounted on a confocal microscope with a z sample stage enabling long-range, high-speed force spectroscopy measurements on biological samples. The control software is built on a field-program...
Reconstruction of the Flexible IgM Fc Core Using Atomic Force Microscopy Topography and the AFM-Assembly Pipeline [0.03%]
基于原子力显微镜形貌和AFM-装配流水线的IgM可变Fc核的重建
Harinderbir Kaur,Andrea J Pinto,Jean-Baptiste Reiser et al.
Harinderbir Kaur et al.
Immunoglobulin M (IgM) is the first class of antibody produced in response to pathogens. It also plays an important role in regulating the immune response, including in autoimmunity. IgM pentamers consist of an Fc core composed of Cμ2, Cμ...
Atomic Force Microscopy Based Single Molecule Recognition: Deciphering Biological Interactions at the Nanoscale [0.03%]
基于原子力显微镜的单分子识别：解码纳米尺度的生物相互作用
Huaiwei Zhang,Qianhui Xu,Junmei Chen et al.
Huaiwei Zhang et al.
Atomic Force Microscopy (AFM) based single molecule recognition has emerged as a transformative paradigm in nanoscale biology, enabling direct investigation of biological interactions under physiological conditions. This technology bridges ...
3D-Printed Structures Versus Drilled Cavities: A Comparison of Microconfinement Methods for Rheological Characterisation of Multicellular Aggregates [0.03%]
三维打印结构与钻孔腔室的对比：多细胞聚集体流变学表征的微限制方法比较
Isis V M Lima,Chukwuma Chris Muoghalu,Shruti G Kulkarni et al.
Isis V M Lima et al.
Three-dimensional (3D) cell culture systems are increasingly recognised as more physiologically relevant models than traditional two-dimensional cultures, as they better mimic the native tumour microenvironment and enable the study of compl...
Comparative Study
Journal of molecular recognition : JMR. 2026 Jul;39(4):e70040. DOI:10.1002/jmr.70040 2026
Temperature Dependent Motions of N-Terminal Loop in PD-1 Determine the Affinity Towards Nivolumab [0.03%]
温度依赖的PD-1 N端环域柔性运动决定其与Nivolumab结合亲和力
Mohammad Karbalaeimahdi,Dircia C C Marcelina,Razvan C Stan
Mohammad Karbalaeimahdi
Programmed Cell Death-1 receptors on the surface of monocytes and T and B cells modulate various immune responses and are key immunotherapy targets. Immunotherapeutic monoclonal antibodies, including Nivolumab, block the activity of this re...
AFM Force Volume for Extracellular Vesicle Detection and Membrane Blebbing Analysis Through Mechanical Signature Mapping [0.03%]
基于机械信号映射的外泌体检测及膜泡破裂分析的原子力显微镜力体积成像技术
F Collacchi,G Corti,M Girasole et al.
F Collacchi et al.
Membrane blebbing is a dynamic cellular phenomenon that plays a key role in numerous biological processes such as migration, apoptosis, cytokinesis, and extracellular vesicle (EV) formation. This phenomenon is traditionally observed via hig...
Induced Circular Dichroism From the Binding of Achiral Bivalent Ligands to Transthyretin [0.03%]
achiral双价配体与铜蓝蛋白结合引起的圆二色性
Stephen Wood,Yiwei Guan,James Pitts et al.
Stephen Wood et al.
Achiral bivalent ligands capable of simultaneous occupation of both hormone binding sites of transthyretin generate a substantial and complex induced near ultraviolet circular dichroism spectrum during protein binding, revealing the dynamic...
Design of Multi-Epitope DIVA-Compatible Vaccine Candidate Against Canine Parvovirus 2 [0.03%]
一种针对犬细小病毒的多抗原B细胞表位候选疫苗的设计及评估
Shubham Sharma,Pratishtha Sharma,Ravindra Pal Mandar et al.
Shubham Sharma et al.
Canine parvovirus type 2 (CPV-2) is a highly contagious and often fatal canine pathogen, with antigenic variants (CPV-2a, 2b, 2c), maternally derived antibody (MDA) interference, and lack of Differentiating Infected from Vaccinated Animals ...
Artificial Intelligence Clustering Approach for Force Mapping Analysis of Polyacrylic Acid (PAA)/Polyethylene Oxide (PEO) Polymer Brushes for Biosensor Applications [0.03%]
用于生物传感器应用的聚丙烯酸(PAA)/聚环氧乙烷(PEO)聚合物刷力图分析的人工智能聚类方法
D Saad,F Dubreuil,A Steinberger et al.
D Saad et al.
Biocompatibility of a biosensor can be achieved by grafting polymer brushes onto a solid surface. These brushes must be able to attract specific analytes or repel unwanted entities. This is obtained with weak polyelectrolyte polymer brushes...
RPA Combined With CRISPR/Cas12a for Rapid and Ultrasensitive Detection Dual-Gene of Methicillin-Resistant Staphylococcus aureus (MRSA) [0.03%]
用于检测耐甲氧西林金黄色葡萄球菌（MRSA）双基因的快速超灵敏RPA与CRISPR / Cas12a联合检测方法
Lei Chen,Jun Luo,Helin Zhang et al.
Lei Chen et al.
The increasing issue of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) necessitates rapid and reliable diagnostic methods. While existing RPA-CRISPR/Cas12a platforms have demonstrated potential for MRSA detection, m...