Ekrem Yasar,Segun Dogru,Erol Eroglu et al.
Ekrem Yasar et al.
The proto-oncogene Mas receptor (MasR) is a class-A (orphan-type) G protein-coupled receptor (GPCR) that mediates the cardioprotective effects of Angiotensin 1-7 (Ang 1-7) within the renin-angiotensin system (RAS). Despite its therapeutic r...
miR-146a/b-5p-IRAK1-NF-κB Axis Regulates Unexplained Recurrent Spontaneous Abortion [0.03%]
microRNA-146a/b-5p-IRAK1-核因子κB轴调控不明原因复发性流产
Fengping He,Shushu Fan,Lujing Chen et al.
Fengping He et al.
Unexplained recurrent spontaneous abortion (URSA) remains a prevalent obstetric issue, the underlying causes of which are still not fully understood. MicroRNAs (miRNAs) have the potential to influence URSA through their regulation of gene e...
Molecular Insights Into Human Serum Albumin Interaction and Binding With Gemini and Pluronic F-127 Binary Surfactants-A Multitechnique Approach [0.03%]
双二元表面活性剂体系中人血清白蛋白结合和相互作用的分子机制研究——多技术方法探究
Deepti Tikariha Jangde,Srishti Sinha,Anjali Sinha et al.
Deepti Tikariha Jangde et al.
This study examined the systematic binding of human serum albumin (HSA) to the non-ionic surfactant Pluronic F-127, gemini surfactant 2-butanol-1, 4-bis (dimethyldodecylammonium bromide) (12-4(OH)-12) and their binary mixtures at 300 K. Whi...
Systematic Identification and Recognition Analysis of Beta1-Adrenergic Receptor Targeting Material Basis in Tibetan Medicine Formula Bawei Chenxiang Powder [0.03%]
藏药巴weitian香粉中肾上腺素受体β1型亚型靶向物质基础的系统识别与鉴定分析
Lixiang Chen,Yunzhi He,Junni Fan et al.
Lixiang Chen et al.
Bawei Chenxiang Powder (BWCP) is a Tibetan medicine formulation used to treat cardiovascular diseases, has demonstrated clinical efficacy though its material basis remains unclear. In clinical trial, β1-adrenergic receptor (β1-AR) has bee...
Energetics Decomposition of Sac7d:DNA Decrypts Amino Acids Role Without DNA Sequence Selectivity [0.03%]
独立于DNA序列选择性的Sac7d：DNA的能垒分解解密了氨基酸的作用
Elena Álvarez-Sánchez,Bernard Offmann,Simon Huet et al.
Elena Álvarez-Sánchez et al.
Sac7d is a 7 kDa protein belonging to the class of the small chromosomal proteins from archeon Sulfolobus acidocaldarius. Sac7d was discovered in 1974 in Yellowstone National Parks geysers, and studied extensively since then for its remarka...
Investigation of the Interaction Between HSA and Dioscorea pentaphylla Leaf Extract-Mediated Silver Nanoparticles Using Multi-Spectroscopic and Calorimetric Techniques and Evaluation of Their Anti-Biofilm Activity [0.03%]
多种光谱和 calorimetric 技术用于研究HSA与山药叶提取物介导的银纳米颗粒相互作用及它们的抗生物膜活性评估
Basudev Shit,Samaresh Paria,Somenath Kundu et al.
Basudev Shit et al.
This study aimed to develop a simple, rapid and eco-friendly method for the synthesis of silver nanoparticles (SNPs) employing the aqueous leaf extract of the medicinal plant Dioscorea pentaphylla as a natural and cost-effective reducing an...
Uncovering the Structural Logic of Grb7: From Domain Mutagenesis to Therapeutic Implications in Cancer Signaling [0.03%]
揭开Grb7的结构逻辑：从结构域点突变到癌症信号转导的治疗意义
Ashis Kumar Biswas,Rajan Koirala,Sharmistha Roy et al.
Ashis Kumar Biswas et al.
Grb7 is a member of the Grb7 protein family, which also includes Grb10 and Grb14. These adaptor proteins function mainly as scaffolds in phosphorylation-dependent signaling pathways. The family is known to interact with receptor tyrosine ki...
Therapeutic Perspectives of SIRT6 Regulation: Computational Analysis of Activation and Inhibition by Bioactive Molecules [0.03%]
SIRT6调控的治疗视角：生物活性分子激活和抑制的计算分析
Érika Geicianny de Carvalho Matias,Katyanna Sales Bezerra,Washington Sales Clemente Junior et al.
Érika Geicianny de Carvalho Matias et al.
Sirtuin 6 (SIRT6) is an enzyme belonging to the class of nicotinamide adenine dinucleotide (NAD+) dependent histone deacetylases. It has been of interest due to its multivariate biological role and association with aging-related diseases an...
Multispectral and Molecular Dynamics Study on the Interactions Between α-Amylase and Four Sesquiterpene Lactone Compounds [0.03%]
基于光谱及分子动力学的四种倍半萜内酯与α-淀粉酶相互作用研究
Xiaoyan Ma,Qianghui Mian,Chengyu Shi et al.
Xiaoyan Ma et al.
This study compared the inhibitory effects and mechanisms of four sesquiterpene lactones derived from Asteraceae plants on α-amylase using enzymatic kinetics, multi-spectral techniques, and molecular docking methods. It was found that comp...
Investigation of Intermolecular Interaction Between 4-Ethyl Phenyl Sulfate and Human Serum Albumin Using Spectroscopic Techniques and Molecular Docking Studies [0.03%]
基于分子对接和光谱技术探讨对乙基苯硫酸与人血清白蛋白间相互作用研究
Harsha Verma,Payal Gulati,Tabarak Malik et al.
Harsha Verma et al.
4-Ethyl phenyl sulfate (4-EPS), a gut microbiota-derived metabolite, is identified in ailments like chronic kidney disease (CKD) and numerous neurodegenerative conditions like autism spectrum disorders (ASD). This study is a novel attempt t...