Measurement of protein concentration in bacteria and small organelles under a light transmission microscope [0.03%]
透射光学显微镜下细菌及小型细胞器内蛋白质浓度的测量方法研究
M A Model,R Guo,K Fasina et al.
M A Model et al.
Protein concentration (PC) is an essential characteristic of cells and organelles; it determines the extent of macromolecular crowding effects and serves as a sensitive indicator of cellular health. A simple and direct way to quantify PC is...
Synthesis, molecular dynamics simulation, and evaluation of biological activity of novel flurbiprofen and ibuprofen-like compounds [0.03%]
新型氟比洛芬和布洛芬类似物的合成、分子动力学模拟及生物活性评价
Mehmet Taha Yıldız,Derya Osmaniye,Begum Nurpelin Saglik et al.
Mehmet Taha Yıldız et al.
The frequent use of anti-inflammatory drugs and the side effects of existing drugs keep the need for new compounds constant. For this purpose, flurbiprofen and ibuprofen-like compounds, which are frequently used anti-inflammatory compounds ...
Identification of DPP-IV inhibitory peptides derived from buffalo colostrum: Mining through bioinformatics, in silico and in vitro approaches [0.03%]
通过生物信息学、计算机模拟和体外方法从水牛初乳中鉴定二肽基肽酶Ⅳ抑制肽
Arpitha Ashok,Aparna H S
Arpitha Ashok
Bioactive peptides derived from foods provide physiological health benefits beyond nutrition. This study focused on profiling small peptide inhibitors against two key serine proteases, dipeptidyl peptidase-IV (DPP-IV) and prolyl oligopeptid...
Changfeng Cao,Guangxu Zhang,Xueling Li et al.
Changfeng Cao et al.
The development of effective therapeutics against COVID-19 requires a thorough understanding of the receptor recognition mechanism of the SARS-CoV-2 spike (S) protein. Here the multidomain collective dynamics on the trimer of the spike prot...
A versatile ratiometric fluorescence nanoprobe for the determination of clonazepam in patients' plasma samples [0.03%]
一种通用的比率荧光纳米探针用于患者血浆中氯硝西泮的测定
Mohammad Abbasi,Abolghasem Jouyban,Fatemeh Ranjbar et al.
Mohammad Abbasi et al.
Despite the necessity of the study of therapeutic drug monitoring of clonazepam (CLZ), there are only a few fast detection methods available for determining CLZ in biological media. This study aims to develop a cost-effective and ratiometri...
Dual template (epitope) imprinted electrode for sensing bacterial protein with high selectivity [0.03%]
双重模板（表位）印迹电极检测细菌蛋白质高选择性传感器
Akriti Srivastava,Manjeet Harijan,Rajniti Prasad et al.
Akriti Srivastava et al.
Epitope imprinting has shown better prospects to synthesize synthetic receptors for proteins. Here, dual epitope imprinted polymer electrode (DEIP) matrix was fabricated on gold surface of electrochemical quartz crystal microbalance (EQCM) ...
Integrated spectroscopic and computational analyses unravel the molecular interaction of pesticide azinphos-methyl with bovine beta-lactoglobulin [0.03%]
集成光谱及计算分析揭示了农药灭害灵分子与牛β-乳球蛋白之间的相互作用
Nasser Abdulatif Al-Shabib,Javed Masood Khan,Ajamaluddin Malik et al.
Nasser Abdulatif Al-Shabib et al.
Organophosphorus are typically hazardous chemicals used in the pharmaceutical, agricultural, and other industries. They pose a serious risk to human life and can be fatal upon direct exposure. Hence, studying the interaction between such co...
Dissimilar effects of the hydrophilic carbon dots on the amyloid aggregation of two model proteins and the mechanism discussion [0.03%]
疏水性碳点对两种模型蛋白淀粉样纤维组装的差异影响及机制探讨
Jie Li,Yuangong Zhang,Jiawei Dong et al.
Jie Li et al.
Many proteins could aggregate into amyloid fibrils under certain conditions. However, the aggregation process and morphology of the fibrils may be significantly different because of the distinct protein structure. In this article, the hydro...
Exploring the interaction of a potent anti-cancer drug Selumetinib with bovine serum albumin: Spectral and computational attributes [0.03%]
塞鲁米替尼与牛血清白蛋白相互作用的光谱和计算研究
Ankita Jalan,Satyam Sangeet,Amit Kumar Pradhan et al.
Ankita Jalan et al.
The binding of drugs to plasma proteins determines its fate within the physiological system, hence profound understanding of its interaction within the bloodstream is important to understand its pharmacodynamics and pharmacokinetics and the...
Some pyrroles as inhibitors of the pentose phosphate pathways enzymes: An in vitro and molecular docking study [0.03%]
作为戊糖磷酸途径酶抑制剂的一些吡咯：体外和分子对接研究
Muhammet Serhat Özaslan
Muhammet Serhat Özaslan
Glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) are pentose phosphate pathway enzymes. Compounds with a heterocyclic pyrrole ring system containing this atom can be derivatized with various functional gr...