Utilizing fab fragment-conjugated surface plasmon resonance-based biosensor for detection of Salmonella Enteritidis [0.03%]
利用联有片段fab的表面等离子共振生物传感器检测鸡沙门氏菌
Esma Eser,Okan Öner Ekiz,H İbrahim Ekiz
Esma Eser
Although antibodies, a key element of biorecognition, are frequently used as biosensor probes, the use of these large molecules can lead to adverse effects. Fab fragments can be reduced to allow proper antigen-binding orientation via thiol ...
Biophysical and structural characterization of tetramethrin serum protein complex and its toxicological implications [0.03%]
四甲醚杀虫剂血清蛋白复合物的生物物理和结构表征及其毒理学意义
Pratik Singh,Priyanka Gopi,Majji Sai Sudha Rani et al.
Pratik Singh et al.
Tetramethrin (TMT) is a commonly used insecticide and has a carcinogenic and neurodegenerative effect on humans. The binding mechanism and toxicological implications of TMT to human serum albumin (HSA) were examined in this study employing ...
Investigation of steric hindrance effect on the interactions between four alkaloids and HSA by isothermal titration calorimetry and molecular docking [0.03%]
通过等温滴定量热法和分子对接研究四种生物碱与HSA之间的空间位阻效应对其相互作用的影响
Xinluan Lv,Wenjin Li,Miao Zhang et al.
Xinluan Lv et al.
The binding of four alkaloids with human serum albumin (HSA) was investigated by isothermal titration calorimetry (ITC), spectroscopy and molecular docking techniques. The findings demonstrated that theophylline or caffeine can bind to HAS,...
Spectroscopic, computational, cytotoxicity, and docking studies of 6-bromobenzimidazole as anti-breast cancer agent [0.03%]
6-溴苯并咪唑作为抗乳腺癌药物的光谱、计算、细胞毒性和对接研究
V S Kunjumol,S Jeyavijayan,S Sumathi et al.
V S Kunjumol et al.
6-Bromobenzimidazole (6BBZ) has been calculated in this study utilizing the 6-311++G(d,p) basis set and the Becke-3-Lee-Yang-Parr density functional approaches. The basic frequencies and geometric optimization are known. FTIR, FT-Raman, and...
Immune infiltration is associated with pan-cancer prognostic biomarker RING finger protein 187 [0.03%]
免疫浸润与泛癌预后生物标志物RING指蛋白187有关
Xin-Tong Fan,Bing-Fang Gao,Xiao-Fei Wang et al.
Xin-Tong Fan et al.
Cancer is associated with the highest mortality rate globally. While life-saving screening and treatments exist, better awareness is needed. RNF187, an E3 ligase regulating biological processes, belongs to the RING domain-containing E3 liga...
Nucleic acid-based electrochemical biosensor for detection of influenza B by gold nanoparticles [0.03%]
基于核酸的电化学生物传感器通过金纳米粒子检测B型流感病毒
Isar Yahyavi,Fahime Edalat,Neda Pirbonyeh et al.
Isar Yahyavi et al.
The influenza virus is a pervasive pathogen that exhibits increased prevalence during colder seasons, resulting in a significant annual occurrence of infections. Notably, pharmaceutical interventions effective against influenza A strains of...
Thermodynamic and structural investigation of the interaction of quaternized 2,3-octakis-[(2-mercaptopyridine)phthalocyaninato] copper (II) sulfate (CuPc) with parallel and hybrid type G-quadruplex [0.03%]
四烷基化2,3-八(2-巯基吡啶)铜（II）硫酸盐酞菁(CuPc)与平行型和杂合型G-四链体相互作用的热力学及结构研究
Gamze Şahin,Esra Bağda,Özge Göktuğ Temiz et al.
Gamze Şahin et al.
G-quadruplexes are important drug targets and get attention due to their existence in telomere, ribosomal DNA, promoter regions of some oncogenes, and the untranslated regions of mRNA. Due to the biological roles of G-quadruplexes, investig...
An integrated docking and molecular dynamics simulation approach to discover potential inhibitors of activin receptor-like kinase 1 [0.03%]
一种整合对接与分子动力学模拟的方法发现激活素受体样激酶1的潜在抑制剂
Deeba Shamim Jairajpuri,Taj Mohammad,Afzal Hussain et al.
Deeba Shamim Jairajpuri et al.
Activin receptor-like kinase 1 (ALK1) is a transmembrane receptor involved in crucial signaling pathways associated with angiogenesis and vascular development. Inhibition of ALK1 signaling has emerged as a promising therapeutic strategy for...
Structure-based improvement of the binding affinity and recognition specificity of peptide competitors to target pediatric IL-5R/IL-5 interaction by gluing halogen bonds at their complex interface [0.03%]
通过在复合物界面上粘合卤键来改善肽竞争者与靶向儿科IL-5R / IL-5相互作用的结合亲和力和识别特异性的一种基于结构的方法
Peipei Chu,Yeping Sheng,Chentao Shen et al.
Peipei Chu et al.
Human interleukin-5 (IL-5) cytokine mediates the development of eosinophils and is involved in a variety of immune inflammatory responses that play a major role in the pathogenesis of childhood asthma, leukemia, and other pediatric allergic...
Understanding the riddle of amine oxidase flavoenzyme reactivity on the stereoisomers of N-methyl-dopa and N-methyl-tyrosine [0.03%]
胺氧化酶 flavoenzyme 与 D, L-N-甲基多巴和D,L-N-甲基酪氨酸立体异构体反应性之谜的理解
Oriol Gracia Carmona,Majd Lahham,Peter Poliak et al.
Oriol Gracia Carmona et al.
Enzymes are usually stereospecific against chiral substrates, which is commonly accepted for the amine oxidase family of enzymes as well. However, the FsqB (fumisoquin biosynthesis gene B) enzyme that belongs to the family of sarcosine oxid...