Repurposing FDA-Approved Drugs to Target MTH1 for Anticancer Therapeutics [0.03%]
再利用美国食品药品监督管理局已批准的药物靶向MTH1用于抗癌药物
Aaliya Taiyab,Md Nayab Sulaimani,Aanchal Rathi et al.
Aaliya Taiyab et al.
Cancer cells exhibit elevated levels of reactive oxygen species, resulting in oxidative stress and DNA damage. To counteract this, many cancers upregulate the expression of MTH1 (MutT Homolog-1), a crucial enzyme that detoxifies oxidised nu...
Food Additive Hexametaphosphate Promotes Amyloid Formation in Human Serum Albumin: A Molecular Insight [0.03%]
六偏磷酸钠作为食品添加剂促进人血清白蛋白淀粉样纤维化分子机制研究
Nasser Abdulatif Al-Shabib,Javed Masood Khan,Ajamaluddin Malik et al.
Nasser Abdulatif Al-Shabib et al.
This study investigates the aggregation behavior of human serum albumin (HSA) in its cationic (pH 2.0) and anionic (pH 8.0) states upon exposure to hexametaphosphate (HMP), a polyanionic compound. UV-Vis turbidity measurements revealed that...
Nanohydrogel of Curcumin/Berberine Co-Crystals Induces Apoptosis via Dual Covalent/Noncovalent Inhibition of Caspases in Endometrial Cancer Cell Lines: The Synergy Between Pharmacokinetics and Pharmacodynamics [0.03%]
姜黄素/小檗碱共晶纳米水凝胶通过胱天蛋白酶的双共价/非共价抑制诱导子宫癌细胞系凋亡：药代动力学和药效学之间的协同作用
Feiyan Yan,Yan Wang,Lin Chen et al.
Feiyan Yan et al.
Endometrial cancer remains a significant therapeutic challenge due to drug resistance and heterogeneity. This study leverages the synergistic potential of curcumin (CUR) and berberine (BBR) co-crystals encapsulated in a nanohydrogel to addr...
Signal Transduction by Phase Separation-Unnoticed Revolution in Molecular Biology [0.03%]
通过相分离进行信号转导—分子生物学中不被注意的革命
Semen V Nesterov,Nikolay S Ilyinsky,Alexander V Fonin et al.
Semen V Nesterov et al.
Recent scientific findings highlight the crucial role of liquid-liquid phase separation (LLPS) in the compartmentalization of enzyme systems. A synthesis of the extant data indicates that lipid rafts and condensates formed by phase separati...
Inhibitory Potential and Binding Thermodynamics of Scyllatoxin-Based BH3 Domain Mimetics Targeting Repressor BCL2 Proteins [0.03%]
基于天青毒素的模拟BH3结合抑制抗凋亡Bcl-2蛋白的潜力及热力学研究
H A D B Amarasiri,Danushka Arachchige,Matthew J K Vince et al.
H A D B Amarasiri et al.
The B-cell lymphoma 2 (BCL2) proteins are a class of apoptosis regulators that control the release of apoptogenic factors from mitochondria. Under normal physiological conditions, apoptosis is inhibited through the actions of anti-apoptotic...
A Serum D-Fucose Binding Lectin With B Cell Mitogenic Activity From the Grub of the Darkling Beetle Zophobas morio [0.03%]
来自暗谷虫Zophobas morio的幼虫的一种具有B细胞增殖活性的血清D-岩藻糖结合伴刀豆蛋白A素
Ramanathan Nivetha,Mani Meenakumari,Sreeramulu Bhuvaragavan et al.
Ramanathan Nivetha et al.
Lectins that can recognize and bind to carbohydrates and glycoconjugates are at the epicentre of research owing to their prospective applications. In the present study, a D-fucose binding lectin from the serum of darkling beetle, Zophobas m...
Deciphering Saquinavir-Bovine Serum Albumin Interactions: Spectroscopic and Computational Insights [0.03%]
克拉维酶-牛血清白蛋白相互作用的光谱和计算研究
Vijayakumar Rajendran,Saravanan Kandasamy,Seshan Gunalan et al.
Vijayakumar Rajendran et al.
Bovine serum albumin (BSA) plays a crucial role as a carrier protein in plasma, binding various ligands, including drugs. Understanding the interaction between BSA and saquinavir, an antiretroviral drug, is essential for predicting its phar...
TAZ-hTrap: A Rationally Designed, Disulfide-Stapled Tead Helical Hairpin Trap to Selectively Capture Hippo Signaling Taz With Potent Antigynecological Tumor Activity [0.03%]
TAZ-hTrap：一种理性设计的二硫键环化的TEAD螺旋发夹陷阱，可选择性捕获Hippo信号通路TAZ，并具有强大的抗妇科肿瘤活性
Bin Tang,Yu Du,Jun Wang
Bin Tang
Transcriptional enhanced associate domain (Tead)-mediated Hippo signaling pathway regulates diverse physiological processes; its dysfunction has been implicated in an increasing number of human gynecological cancers. The transcriptional coa...
Probing the Molecular Basis of Aminoacyl-Adenylate Affinity With Mycobacterium tuberculosis Leucyl-tRNA Synthetase Employing Molecular Dynamics, Umbrella Sampling Simulations and Site-Directed Mutagenesis [0.03%]
运用分子动力学、伞采样模拟和定点突变研究氨酰腺苷酸亲和力的分子基础——以结核分枝杆菌亮氨酰tRNA合成酶为例
Galyna P Volynets,Olga I Gudzera,Mariia O Usenko et al.
Galyna P Volynets et al.
Leucyl-tRNA synthetase (LeuRS) is clinically validated molecular target for antibiotic development. Recently, we have reported several classes of small-molecular inhibitors targeting aminoacyl-adenylate binding site of Mycobacterium tubercu...
Role of Circular RNA MMP9 in Glioblastoma Progression: From Interaction With hnRNPC and hnRNPA1 to Affecting the Expression of BIRC5 by Sequestering miR-149 [0.03%]
环状RNA MMP9在胶质母细胞瘤进展中的作用：从与hnRNPC和hnRNPA1相互作用到通过吸附miR-149影响BIRC5的表达
Javad Amini,Nikta Zafarjafarzadeh,Sara Ghahramanlu et al.
Javad Amini et al.
Glioblastoma multiforme (GBM) presents a significant challenge in neuro-oncology due to its aggressive behavior and self-renewal capacity. Circular RNAs (circRNAs), a subset of non-coding RNAs (ncRNAs) generated through mRNA back-splicing, ...