Studies on Taxol® Biosynthesis. Preparation and Tritium Labeling of Biosynthetic intermediates by Deoxygenation of a Taxadiene Tetra-acetate Obtained from Japanese Yew [0.03%]
生物合成研究.由日本红豆杉得到的紫杉四乙酸酯去氧制备及氚标记中间体的研究
Tohru Horiguchi,Christopher D Rithner,Rodney Croteau et al.
Tohru Horiguchi et al.
Taxa-4(20),11(12)-diene-5α-acetate 5 and Taxa-4(20), 11(12)-diene-5α-acetate, 10β-ol 6, have been identified as early stage intermediates involved in the biosynthesis of Taxol® (paclitaxel). Tritium-labeled 5 and 6 were successfully pre...
Insights into the mechanisms of flavoprotein oxidases from kinetic isotope effects [0.03%]
源自同位素效应的动力学机制研究方面的见解——黄素蛋白氧化酶类的一个实例
Paul F Fitzpatrick
Paul F Fitzpatrick
Deuterium, solvent, and (15)N kinetic isotope effects have been used to probe the mechanisms by which flavoproteins oxidize carbon-oxygen and carbon-nitrogen bonds in amines, hydroxy acids, and alcohols. For the amine oxidases d-amino acid ...
Synthesis of 2-(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamidoethyl-d(4) Dihydrogen Phosphate, Tetra-deuterated pAEA [0.03%]
2-(5Z,8Z,11Z,14Z)-二十-5,8,11,14-四烯胺基乙基-D4二氢磷酸的合成，四氘代pAEA
Kejun Cheng,Bijali Saha,A Mahadevan et al.
Kejun Cheng et al.
A labile intermediate phospho-anandamide (2-(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenamidoethyl dihydrogen phosphate, pAEA) has been identified in mouse brain and macrophages, but its precise quantitation was difficult because of its low conc...
Synthesis, radiosynthesis and in vivo evaluation of [I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine as a selective tracer for imaging the dopamine transporter [0.03%]
[I]4-[2-（双（4-氟苯基）甲氧基）乙基]-1-（4-碘代苄基）环己基哌啶的合成、放射性标记及体内评价作为一种多巴胺转运体选择性示踪剂
S De Bruyne,T L Boos,L Wyffels et al.
S De Bruyne et al.
Dopamine transporter (DAT) neuroimaging is a useful tool in Parkinson's disease diagnosis, staging and follow-up providing information on the integrity of the dopaminergic neurotransmitter system in vivo. 4-(2-(Bis(4-fluorophenyl)-methoxy)e...
Enantiomeric radiochemical synthesis of R and S (1-(6-amino-9H-purin-9-yl)-3-fluoropropan-2-yloxy)methylphosphonic acid (FPMPA) [0.03%]
(R和S)-1-(6-氨基嘌呤-9-基)-3-氟丙-2-醇氧甲基膦酸的对映体放射化学合成
Dale O Kiesewetter,Kathleen Knudson,Matt Collins et al.
Dale O Kiesewetter et al.
Therapy for human immunodeficiency virus (HIV)-infected patients requires chronic multidrug administration. The eventual failure of therapy in some patients has brought into question the tissue concentration of the drugs. With an appropriat...
Synthesis of 19-Trideuterated ent-Testosterone and the GABA(A) Receptor Potentiators ent-Androsterone and ent-Etiocholanolone [0.03%]
19位三氘代恩-睾酮及恩-雄烷酮和恩-齐奥胆烷醇酮（GABA(A)受体增效剂）的合成
Shirisha Komarapuri,Kathiresan Krishnan,Douglas F Covey
Shirisha Komarapuri
19-Trideuteromethyl enantiomers of androgens namely ent-testosterone, ent-androsterone and ent-etiocholanolone were prepared by total synthesis. The isotope labeling at the carbon-19 angular methyl group was achieved by using deuterated met...
Synthesis of deuterium-labelled 5'-O-[N-(Salicyl)sulfamoyl]adenosine (Sal-AMS-d(4)) as an internal standard for quantitation of Sal-AMS [0.03%]
用于定量分析萨利-腺苷甲硫胺的内标的合成：氘代5'-O-[N-(水杨基)磺酰]-腺苷(Sal-AMS-d(4))
Amol Gupte,Murali Subramanian,Rory P Remmel et al.
Amol Gupte et al.
5'-O-[N-(Salicyl)sulfamoyl]adenosine (Sal-AMS, 1) is a potent inhibitor of the bifunctional enzyme salicyl-AMP ligase in Mycobacterium tuberculosis. This inhibitor acts by disrupting the biosynthesis of the mycobactin siderophores that are ...
Facile preparation of leukotrienes C(4), D(4) and E(4) containing carbon-13 and nitrogen-15 for quantification of cysteinyl leukotrienes by mass spectrometry [0.03%]
用于质谱定量的含碳-13和氮-15的白三烯C(4)、D(4)和E(4)的简便制备方法
Farideh Ghomashchi,James G Bollinger,Michael H Gelb
Farideh Ghomashchi
With the recent ability to use combined liquid chromatography/electrospray tandem mass spectrometry to analyze for several eicosanoids in biological samples in a single and rapid experiment, heavy isotope-labeled eicosanoids are needed as i...
Convenient syntheses of [20,20,20-H(3)]-arachidonic acid and [20,20-H(2)]-20-hydroxyeicosatetraenoic acid [0.03%]
[20,20,20-H(3)]花生四烯酸和[20,20-H(2)]-20-羟基二十碳四烯酸的简便合成方法
J R Falck,Siddam Anjaiah,Venugopal Raju Tuniki et al.
J R Falck et al.
Deuterated arachidonic acid and 20-HETE were prepared in good overall yields and high stereoselectivities. Key transformations include a trans-specific vinyl dibromide reduction and Suzuki cross-couplings to a lithium borate or a 9-BBN bora...