[carbonyl-C]Benzyl acetate: automated radiosynthesis via Pd-mediated [C]carbon monoxide chemistry and PET measurement of brain uptake in monkey [0.03%]
[Boc-C]醋酸苄酯：钯介导的[Pd]-碳一氧化学自动化放射合成及猴脑摄取的PET测定
Shuiyu Lu,Jinsoo Hong,Tetsuji Itoh et al.
Shuiyu Lu et al.
[carbonyl-(11)C]Benzyl acetate ([(11)C]1) has been proposed as a potential agent for imaging glial metabolism of acetate to glutamate and glutamine with positron emission tomography (PET). [(11)C]1 was synthesized from [(11)C]carbon monoxid...
(R)-N-Methyl-3-(3'-[F]fluoropropyl)phenoxy)-3-phenylpropanamine (F-MFP3) as a potential PET imaging agent for norepinephrine transporter [0.03%]
(F)-氟代丙基异噁唑衍生物F-MFP3作为去甲肾上腺素转运蛋白的PET显像剂研究
Vivien L Nguyen,Rama Pichika,Paayal H Bhakta et al.
Vivien L Nguyen et al.
A decline of norepinephrine transporter (NET) level is associated with several psychiatric and neurological disorders. Therefore positron emission tomography (PET) imaging agents are greatly desired to study the NET pathway. We have develop...
Synthesis of site-specifically deuterated arachidonic acid derivatives containing a remote tritium radiolabel [0.03%]
合成特定位置氘代花生四烯酸衍生物，其中含有远程氚放射性标记物
Chris M McGinley,Wilfred A van der Donk
Chris M McGinley
The synthesis of arachidonic acid derivatives containing site-specifically incorporated deuterium atoms and also a remote tritium label are described. Deuterium incorporation at the C11 and/or C15 position was achieved using Wittig chemistr...
The synthesis of deuterium-labeled spermine, N-acetylspermine and N-acetylspermidine [0.03%]
重标记的底物精胺、N-乙酰精胺和N-乙酰脊氨的合成
Vijay Gawandi,Paul F Fitzpatrick
Vijay Gawandi
The synthesis of deuterium labeled spermine, N(1)-acetylspermine and N(1)-acetylspermidine is reported. 1,1,3,3-(2)H(4)-N(1)-Acetylspermine hydrochloride, 1,1,3,3-(2)H(4)-N(1)-acetylspermidine hydrochloride and 1,1,3,3,10,10,12,12-(2)H(8)-s...
Joseph A Kozocas,James E Bupp,Mary J Tanga et al.
Joseph A Kozocas et al.
The preparation of 2',4',6'-[(3)H(3)]-(R,R)-4-methoxyfenoterol, a tritium-labeled derivative of (R,R)-4-methoxyfenoterol was demonstrated on a 15 mCi scale providing material with a specific activity of 57 Ci/mmol.
Studies on Taxol® Biosynthesis. Preparation and Tritium Labeling of Biosynthetic intermediates by Deoxygenation of a Taxadiene Tetra-acetate Obtained from Japanese Yew [0.03%]
生物合成研究.由日本红豆杉得到的紫杉四乙酸酯去氧制备及氚标记中间体的研究
Tohru Horiguchi,Christopher D Rithner,Rodney Croteau et al.
Tohru Horiguchi et al.
Taxa-4(20),11(12)-diene-5α-acetate 5 and Taxa-4(20), 11(12)-diene-5α-acetate, 10β-ol 6, have been identified as early stage intermediates involved in the biosynthesis of Taxol® (paclitaxel). Tritium-labeled 5 and 6 were successfully pre...
Insights into the mechanisms of flavoprotein oxidases from kinetic isotope effects [0.03%]
源自同位素效应的动力学机制研究方面的见解——黄素蛋白氧化酶类的一个实例
Paul F Fitzpatrick
Paul F Fitzpatrick
Deuterium, solvent, and (15)N kinetic isotope effects have been used to probe the mechanisms by which flavoproteins oxidize carbon-oxygen and carbon-nitrogen bonds in amines, hydroxy acids, and alcohols. For the amine oxidases d-amino acid ...
Synthesis of 2-(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamidoethyl-d(4) Dihydrogen Phosphate, Tetra-deuterated pAEA [0.03%]
2-(5Z,8Z,11Z,14Z)-二十-5,8,11,14-四烯胺基乙基-D4二氢磷酸的合成，四氘代pAEA
Kejun Cheng,Bijali Saha,A Mahadevan et al.
Kejun Cheng et al.
A labile intermediate phospho-anandamide (2-(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenamidoethyl dihydrogen phosphate, pAEA) has been identified in mouse brain and macrophages, but its precise quantitation was difficult because of its low conc...
Synthesis, radiosynthesis and in vivo evaluation of [I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine as a selective tracer for imaging the dopamine transporter [0.03%]
[I]4-[2-（双（4-氟苯基）甲氧基）乙基]-1-（4-碘代苄基）环己基哌啶的合成、放射性标记及体内评价作为一种多巴胺转运体选择性示踪剂
S De Bruyne,T L Boos,L Wyffels et al.
S De Bruyne et al.
Dopamine transporter (DAT) neuroimaging is a useful tool in Parkinson's disease diagnosis, staging and follow-up providing information on the integrity of the dopaminergic neurotransmitter system in vivo. 4-(2-(Bis(4-fluorophenyl)-methoxy)e...
Enantiomeric radiochemical synthesis of R and S (1-(6-amino-9H-purin-9-yl)-3-fluoropropan-2-yloxy)methylphosphonic acid (FPMPA) [0.03%]
(R和S)-1-(6-氨基嘌呤-9-基)-3-氟丙-2-醇氧甲基膦酸的对映体放射化学合成
Dale O Kiesewetter,Kathleen Knudson,Matt Collins et al.
Dale O Kiesewetter et al.
Therapy for human immunodeficiency virus (HIV)-infected patients requires chronic multidrug administration. The eventual failure of therapy in some patients has brought into question the tissue concentration of the drugs. With an appropriat...