The Role of the p62-Keap1-Nrf2 Pathway in Protecting Sertoli Cells Against Mono-(2-ethylhexyl)phthalate-induced Ferroptosis [0.03%]
p62-Keap1-Nrf2信号通路在支持Sertoli细胞抵抗邻苯二甲酸二丁酯诱导的铁死亡中的作用研究
Siyuan Wang,Dinggang Li,Wei Deng et al.
Siyuan Wang et al.
Di-(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer linked to testicular toxicity. Mono-(2-ethylhexyl) phthalate (MEHP) is the main bioactive metabolite of DEHP. The aim of this study was to investigate the protective role of th...
Toxicological Assessment of Melamine-Functionalized Graphene Oxide and Carbon Nanotubes Using Zebrafish Models [0.03%]
基于斑马鱼模型的三聚氰胺功能化氧化石墨烯和碳纳米管的毒理学评估研究
Aybek Yiğit,Serkan Yıldırım,Mine Köktürk et al.
Aybek Yiğit et al.
Graphene oxide (GO) and carbon nanotube (CNT)-based nanomaterials have attracted significant interest in various industrial and biomedical applications due to their unique physicochemical properties; however, concerns about their potential ...
Novel Toxicokinetics and Metabolic Insights Into Arsenic in Biological Systems From Realgar-Indigo naturalis Formula [0.03%]
红砒丸中药复方中砷的新毒代动力学及代谢机制生物学效应研究
Kaifeng Huang,Yunxia Shi,Youhui Xu et al.
Kaifeng Huang et al.
Realgar-Indigo naturalis Formula (RIF) is the only oral arsenic formulation approved globally and serves as a first-line treatment for acute promyelocytic leukemia (APL), and its safety profile remains a critical clinical concern though. Fo...
Nickel Ferrite Nanoparticles Potentiate the Anticancer Effects of Doxorubicin in Human Lung A549 Cancer Cells [0.03%]
镍铁尖晶石纳米颗粒增强多柔比星对人类肺腺癌A549细胞的抗癌作用
Seda Askin,Bahri Avci,Hilal Kiziltunc Ozmen et al.
Seda Askin et al.
Nickel ferrite (NiFe₂O₄) nanoparticles, a class of Fe-based magnetic nanoparticles (MNPs), have attracted increasing attention for cancer therapy because of their biocompatibility, magnetic responsiveness, and potential to enhance the eff...
Use of the TIPS Technique as a Possible Method of Acute Inhalation Toxicity Assessment [0.03%]
TIPS技术作为急性吸入毒性评估的一种可能方法的使用
Dina Mourad Saleh,Omnia Hosny Mohamed Ahmed,David B Alexander et al.
Dina Mourad Saleh et al.
Acute inhalation toxicity studies provide crucial information regarding short-term exposure to volatile chemicals and help to ensure the safe handling and use of these chemicals. However, acute inhalation toxicity assessment requires specia...
Dysregulation of mTOR, GADD45a, and CDKN1A in HepG2/C3A Spheroids Treated With Ursolic Acid [0.03%]
白桦脂酸处理的HepG2/C3A类器官球中mTOR、GADD45a和CDKN1A失调
Maria Claudia Terkelli de Assis,Luan Vitor Alves de Lima,Liana Martins de Oliveira et al.
Maria Claudia Terkelli de Assis et al.
Phytochemicals are plant-derived compounds extensively studied for the discovery and development of new drugs. Ursolic acid (UA), a pentacyclic triterpenoid phytochemical extracted from the bark and leaves of plants in the Lamiaceae family,...
The Genotoxic Ambiguity of 4-Aminoquinolines: Resolving Hydroxychloroquine's Mechanistic Safety Profile Through Integrated Toxicology Assessment [0.03%]
关于4-氨基喹啉的基因毒模糊性：通过整合毒理学评估解决羟氯喹的安全机制性质问题
Hatice Yildiz,Hasan Basri İla
Hatice Yildiz
Hydroxychloroquine sulfate (HCQ), widely prescribed for autoimmune disorders, carries unresolved concerns regarding potential genotoxic risks. This integrated in vitro assessment comprehensively evaluated HCQ's cytogenotoxic profile using b...
Therapeutic Potential of Phycocyanin in Attenuating Uranium-Induced Neurophysiological Alterations in Adult Male Albino Rats [0.03%]
藻蓝蛋白对减轻铀诱导的雄性 albino 大鼠神经生理变化的治疗潜力
Doaa Mousa,Mohamed M Rezk,Ali Osman et al.
Doaa Mousa et al.
Phycocyanin is a pigment-binding protein extracted from different algae for its great antioxidant and protecting properties. Uranium is a naturally radioactive metal showing many hazards effects on living organisms when exposed to it. The p...
Urbanization and Water Insecurity in Semi-Arid Regions: A Multi-Index Assessment of Water Quality, Ecological Risk, and Public Health Impacts [0.03%]
半干旱地区的城市化与供水安全问题：基于水质、生态风险及公众健康影响的多指标评估方法研究
Muzhda Qasim Qader
Muzhda Qasim Qader
Degradation of water quality remains a critical environmental and public health issue in semi-arid regions, where limited freshwater resources are increasingly stressed by rapid urbanization, intensive agriculture, and industrial activities...
In Vivo Evaluation of the Potential Protective Effect of Prolactin Against Histological Damage Caused by Methylmercury in Testicles of Mice (Mus musculus) [0.03%]
体内评估 prolactin 对甲基汞导致的小鼠睾丸组织损伤的潜在保护作用
Evandro da Conceição Araújo,José Matheus Almeida da Silva,Maria Luiza Cunha E Souza Ferreira et al.
Evandro da Conceição Araújo et al.
Mercury is a heavy metal that naturally occurs in the environment or may be released through anthropogenic activities. Its toxicological impacts are well documented. Prolactin (PRL) is a hormone involved in several physiological processes, ...