Allogeneic Stem Cell Transplantation-A Salvage Option for High-Risk Chronic Lymphocytic Leukemia Patients: A 15-Year Single-Center Experience [0.03%]
异基因干细胞移植对高危慢性淋巴细胞白血病患者的挽救治疗：单一中心15年的经验
Natalia B Mikhailova,Maria I Kislova,Maria O Ivanova et al.
Natalia B Mikhailova et al.
The role of allogeneic hematopoietic cell transplantation (alloSCT) in chronic lymphocytic leukemia (CLL) has decreased in recent years due to the emergence of new effective targeted agents for the treatment of this disease. However, for a ...
Targeting a CDH1-TK1-dependent DNA Synthesis Pathway Overcomes Chemoresistance in Acute Myeloid Leukemia [0.03%]
靶向CDH1-TK1依赖的DNA合成途径可克服急性髓系白血病的化疗耐药性
Xiaomin Feng,Li Huo,Clifford Pang et al.
Xiaomin Feng et al.
Relapsed and refractory acute myeloid leukemia (AML) remains difficult to treat, in part because leukemic cells adapt to nucleoside analogue-induced replication stress. Here, we identify thymidine kinase 1 (TK1) as a functional contributor ...
Studying Chronic Lymphocytic Leukemia Microenvironment in the Multi Omics Era [0.03%]
多组学时代慢性淋巴细胞白血病微环境的研究
Bucci Antonella,Notarpietro Giulia,Apollonio Benedetta et al.
Bucci Antonella et al.
In recent years, chronic lymphocytic leukemia (CLL) has undergone a radical change in the therapeutic landscape, allowing for the complete omission of chemotherapy in favor of targeted drugs. This reflects the improved understanding of the ...
DNA Replication Stress-Induced Transcriptome of Human Burkitt's Lymphoma Identifies Reciprocal Regulation Between MBD1 and BCL6 During Germinal Center-Derived B-Lymphomagenesis [0.03%]
人伯基特淋巴瘤中的DNA复制压力诱导转录组鉴定出MBD1和BCL6在生发中心来源的B细胞系淋巴瘤发生过程中的互为调节关系
Santosh Kumar Gothwal,Kyoko Oichai,Hongtae Kim et al.
Santosh Kumar Gothwal et al.
BCL6 is a master transcriptional regulator of germinal center (GC) B cells. BCL6 is frequently translocated at the major translocation cluster (MTC) within intron 1 of the BCL6 locus, a hotspot commonly rearranged in diffuse large B cell ly...
Defining a Therapeutic Window for Venetoclax in Post-Transplant Maintenance Therapy for High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndromes [0.03%]
定义移植物抗宿主病后维奈克拉治疗高危急性髓系白血病和骨髓增生异常综合征的治疗窗口期
Cuicui Lyu,Tianle Xie,Yedi Pu et al.
Cuicui Lyu et al.
Patients with high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) continue to face a substantial risk of relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which remains a leading cause of tr...
Decoding the Heterogeneity of Diffuse Large B-Cell Lymphomas: A Comprehensive Genetic, Transcriptomic, and Phenotypic Profiling of B-Cell Lymphoma Cell Lines [0.03%]
解码弥漫性大B细胞淋巴瘤的异质性：B细胞淋巴瘤细胞系的全面基因组、转录组和表型分析
Marina Pérez-Aguilera,Lucía Pedrosa,Sagrario Gómez et al.
Marina Pérez-Aguilera et al.
Diffuse large B-cell lymphoma (DLBCL) is the most prevalent form of non-Hodgkin lymphoma, exhibiting significant molecular and clinical heterogeneity. Advances in classification integrating phenotypic, genetic, and transcriptomic features h...
Early Serum Free Light Chain Response in Newly Diagnosed Multiple Myeloma: Documented Earlier Than MRD and Complementary in Prognosis [0.03%]
新诊断的多发性骨髓瘤中早期血清游离轻链反应比MRD更早出现且在预后判断方面互为补充
Yubiao Pan,Yue Wang,Yaqin Xiong et al.
Yubiao Pan et al.
Minimal residual disease (MRD) is the standard for deep response assessment in multiple myeloma but requires bone marrow sampling. Whether early serum free light chain (sFLC) response provides independent prognostic information in real-worl...
A Phase 1 Trial of Duvelisib and Oral Azacitidine in Relapsed/Refractory T-Cell Lymphoma [0.03%]
Duvelisib和口服Azacitidine治疗复发/难治性T细胞淋巴瘤的I期临床试验
Hayder Saeed,Melanie Mediavilla Varela,Eva Sahakian et al.
Hayder Saeed et al.
Mature T-cell lymphomas (TCL) are aggressive malignancies with limited effective therapies. Duvelisib (DUV), a dual inhibitor of PI3K-δ and PI3K-γ, has shown promising activity in TCL. Azacitidine (AZA), a hypomethylating agent, has demon...
Clinical Trial
Hematological oncology. 2026 Sep;44(5):e70235. DOI:10.1002/hon.70235 2026
Longitudinal Monocyte Subset Dynamics as Biomarker in Adult Histiocytosis: Association With Mutational Status, Kinase Inhibitor Exposure and Relapse Risk [0.03%]
成人组织细胞增生症中单核细胞亚群纵向动态变化的生物标志物意义：与突变状态、激酶抑制剂暴露及复发风险的相关性研究
Jerome Razanamahery,Caroline Raymond,Matthias Papo et al.
Jerome Razanamahery et al.