A Tumor Microenvironment-Derived CAF-VEGF Model and Its Application in Biomarker Screening for HCC [0.03%]
一种肿瘤微环境衍生的CAF-VEGF模型及其在HCC生物标志物筛选中的应用
Hao Zheng,Shengwei Tang,Ruida Shi et al.
Hao Zheng et al.
HCC is a highly vascularized solid tumor that develops rapidly and has a poor prognosis. Previous studies have shown that fibroblasts and angiogenesis in the tumor microenvironment play significant roles in the progression of HCC, and the c...
Fatih Çöllü,Hayrettin Kadinşah,Zübeyde Öztel et al.
Fatih Çöllü et al.
Multidrug resistance (MDR) remains a major challenge in small cell lung cancer (SCLC), limiting the efficacy of chemotherapeutics like doxorubicin. This study investigates whether silencing cellular prion protein (PrP), a known MDR-associat...
Ya-An Lan,Jia-Xi Guo,Min-Hua Yao et al.
Ya-An Lan et al.
Itching is an unpleasant sensory experience that induces the desire to scratch and is clinically divided into histamine-dependent and non-dependent types, with the former being the main clinical type. Its pathogenesis mainly involves mast c...
Unveiling the 12-Hour Ultradian Rhythm: Biological Foundations, Mechanistic Insights, and Potential Applications [0.03%]
揭开12小时超日节律：生物学基础、机制洞察及其潜在应用
Jiayi Song,Chuyao Wang,Hongyu Li et al.
Jiayi Song et al.
The ~12-h ultradian rhythm (circasemidian) represents an evolutionarily conserved temporal architecture that complements the canonical 24-h circadian clock. Over the past 5 years, mounting evidence has revealed its ubiquity across biologica...
From Endoplasmic Reticulum Homeostasis to Cardiac Protection: The Role of UFMylation in Cardiovascular Diseases [0.03%]
从内质网稳态到心脏保护：UFMylation在心血管疾病中的作用
Liuhong Chen,Wenyuan Xu,Xishun Zhou et al.
Liuhong Chen et al.
The development and progression of cardiovascular diseases (CVDs) are closely linked to an imbalance in endoplasmic reticulum homeostasis. UFMylation, a recently identified ubiquitin-like post-translational modification, plays a crucial rol...
Molecular and Cellular Mechanisms of Sarcopenia: Integrating Fiber-Type Remodeling, Contractile Protein Dynamics, and Systemic Regulatory Pathways [0.03%]
肌肉减少症的分子及细胞机制：整合肌纤维类型重塑、收缩蛋白动力学和全身调节通路
Nikam Rutuja Dilesh,Divyansh Khatri,Richa Shrivastava et al.
Nikam Rutuja Dilesh et al.
Sarcopenia is an age-associated skeletal muscle disorder characterized by progressive declines in muscle mass, strength, and functional performance. A central feature of sarcopenic remodeling is the preferential loss of fast-twitch (Type II...
Comprehensive Overview of Therapeutic Strategies in Colon Cancer: Chemotherapy, Targeted Therapy, and Immunotherapy [0.03%]
结肠癌治疗策略的全面概述：化疗、靶向治疗和免疫治疗
Seerwan Hamadameen Sulaiman,Hemn A H Barzani,Rebaz Anwar Omer et al.
Seerwan Hamadameen Sulaiman et al.
Colon cancer remains a leading global health challenge driven by substantial molecular heterogeneity, complex carcinogenic pathways, and the persistent emergence of therapeutic resistance. This review provides a comprehensive and integrativ...
Regulation of Choroid Plexus Bicarbonate Transporters Following Intraventricular Hemorrhage in Mice [0.03%]
小鼠脑室内出血后脉络丛碳酸氢盐转运体的调节作用
Laura Øllegaard Johnsen,Rasmus Herløw,Rasmus West Knopper et al.
Laura Øllegaard Johnsen et al.
Posthemorrhagic hydrocephalus is a severe complication to intraventricular hemorrhage. The condition results in enlarged brain ventricles and increased intracranial pressure due to accumulation of cerebrospinal fluid (CSF). In this study, t...
Briefing on Nitric Oxide a Signal Molecule in Cancer Metastasis and Therapeutic Target [0.03%]
一氧化氮：癌症转移信号分子及治疗靶点
Seema Kumari
Seema Kumari
Nitric oxide (NO) is an important signaling molecule in maintaining normal physiological processes like blood flow, neurotransmission and immune regulation. In cancer, it exhibits a dual role in context-dependent mechanism. At low levels, i...
Disruption of Cytoskeleton Induces Physiologically and Morphologically Dysfunctional Mitochondria in B-ALL Cells [0.03%]
细胞骨架紊乱诱导B-ALL细胞生理和形态异常的线粒体
Bhanu Priya Awasthi,Bhanupriya Tanwar,Akshi Shree et al.
Bhanu Priya Awasthi et al.
The interaction of cellular organelles is crucial for maintaining intracellular homeostasis, particularly highlighting the impact of the cytoskeleton on mitochondrial dynamics. The aim of our study is to find direct molecular connections be...