Oxidative Stress and Inflammation in Methylmalonic and Propionic Acidemias: A Review [0.03%]
甲基丙二酸血症和丙酸血症中的氧化应激与炎症：综述
Bianca Gomes Dos Reis,Ana Kalise Böttcher,Franciele Fátima Lopes et al.
Bianca Gomes Dos Reis et al.
Methylmalonic acidemia and propionic acidemia are inherited organic acidemias resulting from deficiencies in the enzymes methylmalonyl-CoA mutase and propionyl-CoA carboxylase, respectively. Impaired activity of these enzymes leads to the a...
Targeting Cancer Signaling Pathways With Plant Sterols: Emerging Roles of Stigmasterol, Campesterol, and β-Sitosterol [0.03%]
植物固醇靶向癌症信号通路的的作用：菜油甾醇、谷甾醇和β-谷甾醇的新角色
Suriyakanthan Menaga,Natesan Geetha
Suriyakanthan Menaga
Plant sterols are naturally occurring tetracyclic triterpenes that serve as essential structural components of plant cell membranes. Structurally similar to cholesterol, these bioactive compounds have gained considerable attention for their...
Isolation and Identification of Bacillus velezensis G52 and Its Growth-Promoting Mechanism on Navel Orange Seedlings [0.03%]
枯草芽孢杆菌G52的分离鉴定及其对脐橙苗木的促生机制研究
Wenyuan Zhao,Tao Peng,Haojie Cao et al.
Wenyuan Zhao et al.
This study isolated and screened a multifunctional plant-growth-promoting bacterium, Bacillus sp. G52, from the rhizosphere soil of Gannan navel oranges. Through pot experiments and genomic analysis, the growth-promoting effects and molecul...
Synergistic Induction of Apoptosis by Apocytochrome C and Sodium Aescinate Is Mediated by Excessive Autophagy via the AKT-mTOR-TFEB Signaling Axis [0.03%]
天青蛋白和七叶皂苷钠通过AKT-mTOR-TFEB信号轴诱导过度自噬而协同促凋亡作用
Jia-Wei Sun,Yin-Kang Chen,Liang Ji et al.
Jia-Wei Sun et al.
Cytochrome C (Cyt C) is a central mediator of intrinsic apoptosis, whereas its heme-free precursor, apocytochrome C (APO-Cyt C), competitively inhibits this process. Sodium aescinate (SA), a natural triterpene saponin, is known to facilitat...
Significance of Lipid Metabolism Reprogramming in Tumor Microenvironment and Development of Novel Therapeutic Intervention [0.03%]
肿瘤微环境中脂质代谢从头合成的重新编程及其重要意义和治疗干预措施的新策略研究进展
Pallabi Mondal,Sankar Bhattacharyya
Pallabi Mondal
The metabolic reprogramming of cancer cell has recently gained heightened attention in the field of tumor metastasis. This metabolic reprogramming helps the cancer cells to meet increased energy and biosynthetic requirements. Beyond their s...
CircRNAs in Cutaneous Squamous Cell Carcinoma: Emerging Biomarkers and Potential Therapeutic Targets [0.03%]
皮肤鳞状细胞癌中的环状RNA：新兴生物标志物和潜在治疗靶点
Jie Zou,Wenkang Qian,Jiangfeng Guo
Jie Zou
The prevalence and invasiveness of cutaneous squamous cell carcinoma (cSCC), one of the most prevalent non-melanoma skin malignancies, are increasing annually. Effective biomarkers and targeted therapeutics for locally advanced, metastatic ...
Aporocactus flagelliformis Aqueous Extract Preserves Mitochondrial Integrity Under Glucose-Induced Oxidative Stress in 3T3-L1 Adipocytes [0.03%]
仙人掌旗状属提取物通过保护葡萄糖诱导的氧化压力下的线粒体完整性来发挥抗糖尿病作用
Eun Hye Park,Sung-Jo Kim
Eun Hye Park
Hyperglycemia-induced oxidative stress disrupts mitochondrial homeostasis in adipocytes. This study investigated the biochemical mechanisms by which Aporocactus flagelliformis aqueous extract (AFAE) preserves mitochondrial integrity under g...
Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons [0.03%]
黑素皮质激素受体3不在培养的人类和啮齿动物神经元的主要纤毛中特异性定位
Niels Vos,Alessandro Moro,Wim Van Hul et al.
Niels Vos et al.
The melanocortin-3 receptor (MC3R) and the melanocortin-4 receptor (MC4R), both expressed in hypothalamic nuclei, are key downstream effectors of leptin signaling and play important roles in energy homeostasis. While pathogenic variants in ...
Optogenetic Control of the Integrated Stress Response Limits Glioblastoma Invasion [0.03%]
光遗传学控制应激反应限制胶质母细胞瘤侵袭
Lisa K Månsson,Ethan Dickson,Lun Hao et al.
Lisa K Månsson et al.
The integrated stress response (ISR) is a highly conserved signaling network, allowing cells to adapt and respond to various stressors. With its aggressive spread and high recurrence rates, glioblastoma multiforme (GBM) is one of the toughe...
Hypercapnia-Regulated Molecular Pathways: Mechanistic Insights Into CO₂-Driven Cellular Signaling and Therapeutic Implications [0.03%]
二氧化碳相关的高碳酸血症调节的分子通路：二氧化碳驱动的细胞信号转导机制及治疗意义
Mohammad-Taher Moradi,Sepideh Nouraei,Habibolah Khazaie et al.
Mohammad-Taher Moradi et al.
Long dismissed as a passive marker of ventilatory failure, elevated carbon dioxide (PaCO₂ > 45 mmHg) is now recognized as a potent signaling molecule that orchestrates complex cellular responses. This review synthesizes recent advances rev...