Antiobesogenic, Hypocholesterolemic and Antioxidant Effects of the Fungal (1→3)(1→6)-β-D-Glucan (Botryosphaeran) in Obese and Non-Obese Female Wistar Rats [0.03%]
菌类(1→3)(1→6)-β-D-葡聚糖(botryosphaeran)在肥胖和非肥胖级联大鼠中的抗肥胖、降胆固醇及抗氧化作用
Isabelle Zanata Fabiane,Daniel Izidoro Ferreira da Silva,Délcio Francisco Chagas Netto et al.
Isabelle Zanata Fabiane et al.
Botryosphaeran is an exocellular (1 → 3)(1 → 6)-β-d-glucan that promotes significant metabolic effects in male rats, as antiobesogenic and hypoglycemic effects. This study aimed to investigate its metabolic effects in female Wistar rats ...
Acidic pH Greatly Enhances Calbindin-D28K's Inhibitory Effect on Caspase-3: Implications for Alzheimer's Therapeutics [0.03%]
酸性PH可大幅增强钙结合素D28k对半胱天冬酶3的抑制作用：阿尔茨海默病治疗的启示
Jude Kinkead,Richele J Thompson,Morgan E Milton et al.
Jude Kinkead et al.
In Alzheimer's disease (AD), the interaction between many AD-relevant proteins, including amyloid precursor protein (APP) and tau, with the cysteine protease caspase-3 (Cas3) enhances AD pathogenesis. Searching for effective Cas3 inhibitors...
Mitochondrial Dysfunction Drives Oxidative Stress and Energy Imbalance in a Murine Model of Spondyloarthritis [0.03%]
线粒体功能障碍驱动轴突炎症小鼠模型中的氧化应激和能量失衡
Rodrigo Prieto-Carrasco,Susana Aideé González-Chávez,Eduardo Chaparro-Barrera et al.
Rodrigo Prieto-Carrasco et al.
Joint inflammation and structural damage in spondyloarthritis (SpA) are not fully explained by known immune mechanisms. While mitochondrial dysfunction has been implicated in other rheumatic diseases, such as rheumatoid arthritis and lupus,...
Hypoxic Mesenchymal Stem Cell Exosome-Derived SLC25A3 Ameliorates Bronchopulmonary Dysplasia by Modulating Macrophage Polarization and Oxidative Stress [0.03%]
缺氧间充质干细胞外泌体衍生的SLC25A3通过调节巨噬细胞极化和氧化应激来改善支气管肺发育不良
Yanfang Zhang,Aimin Zhang,Jiale Yang et al.
Yanfang Zhang et al.
Bronchopulmonary dysplasia (BPD) is a prevalent chronic lung disease in preterm infants, characterized by dysregulated macrophage polarization and oxidative stress. While mesenchymal stem cell-derived exosomes (MSC-Exos) have shown protecti...
Exploring New Pathways of Advanced Oxidation Protein Products Formation: The Role of Hypochlorous Acid and Potassium Cyanate in Protein Modification [0.03%]
高级氧化蛋白产物形成新途径的探索：次氯酸和氰酸钾在蛋白质修饰中的作用
Carolina Dos Santos Stein,Bruna Garlet Rossato,Andiara Prates Ramos et al.
Carolina Dos Santos Stein et al.
Advanced oxidation protein products (AOPP) are generated from oxidation that is mainly promoted by the action of hypochlorous acid (HOCl) on proteins, such as albumin. However, new pathways and targets associated with AOPP formation must be...
Identification of Critical Hub Genes and Pathways Regulating Chemotherapy Responses in Triple-Negative Breast Cancer: An Integrated Analysis [0.03%]
三阴性乳腺癌化疗反应调控的关键枢纽基因和通路的识别：综合分析
Seyedehfatemeh Ashabi,Elaheh Mavadat,Mahboubeh Moradalizadeh et al.
Seyedehfatemeh Ashabi et al.
Triple-negative breast cancer (TNBC) signifies an enormous risk to women's health globally. TNBC is characterized by its aggressive nature, resistance to existing therapies, and poor prognosis. Understanding the molecular pathogenesis of br...
cGAS-STING Signaling in Central Nervous System Diseases: Neuroinflammatory Mechanisms and Immune Regulation [0.03%]
环苷酸合成酶-干扰素基因刺激剂信号通路在中枢神经系统疾病中的作用：神经炎症机制和免疫调节作用
Wujun Wang,Lijuan Wang,Xintong Zhong et al.
Wujun Wang et al.
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway has emerged as a critical cytosolic DNA-sensing mechanism that orchestrates innate immune activation in response to cellular stress. In the central nervous syst...
Sustained Release of Bone Morphogenetic Protein 2/Chitosan-Collagen Scaffold Repairs Rabbit Knee Joint Cartilage Defects [0.03%]
骨形态生成蛋白2/壳聚糖-胶原支架修复兔膝关节软骨缺损的持续释放效应
Hao Song,Dongxu Tang,Buyu Wang et al.
Hao Song et al.
To explore the effects of a collagen-binding domains-bone morphogenetic protein 2 (CBD-BMP-2) scaffold on repairing cartilage defects. A chitosan-collagen scaffold was prepared and its physicochemical properties were evaluated. A plasmid en...
Exploring the Impact of NRF2 Signaling on Atherosclerosis: Insights Into Hydrogen Sulfide, NLRP3 Inflammasome, microRNAs, and HO-1 [0.03%]
NRF2信号对动脉粥样硬化影响的研究：氢硫化物、NLRP3炎性体、microRNA及HO-1的启示
Chen-Yi Shao,Xing-Lin Feng,Ran Hao et al.
Chen-Yi Shao et al.
Atherosclerosis (AS) is a chronic cardiovascular disorder characterized by lipid accumulation and the formation of atherosclerotic plaques on the arterial walls, leading to arterial stenosis and serving as a principal pathological feature. ...
Prognostic Value and Mechanism of Antibody-Dependent Cellular Cytotoxicity-Related Gene, NEU1, in Oral Squamous Cell Carcinoma [0.03%]
NEU1基因介导的抗体依赖性细胞毒性在口腔鳞癌中的预后价值及机制研究
Weiping Zhao,Chunyu Chen
Weiping Zhao
This study aimed to investigate the prognostic significance and molecular mechanisms of antibody-dependent cell-mediated cytotoxicity-related genes (ADCC-RGs) in oral squamous cell carcinoma (OSCC). Transcriptomic data sets and clinicopatho...