Determination of Coblopasvir in Mouse Plasma by Liquid Chromatography-Tandem Mass Spectrometry and Its Application to Pharmacokinetic Study [0.03%]
LC-MS/MS测定小鼠血浆中coboltasvir及其药动学研究
Zhongjie Shi,Yunhui Chen,Jinfang Jiang et al.
Zhongjie Shi et al.
This study aims to develop and validate a highly sensitive and high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of coblopasvir in mouse plasma and to apply it to a pharmacokinetic study....
Pharmacokinetic Characteristics of 6-Hydroxykaempferol-3,6-Diglucoside in Normal and Diabetic Cardiomyopathy Mice [0.03%]
6-羟基京尼 Rud 曲环酮-3,6-二葡萄糖苷在正常和糖尿病心肌病小鼠体内的药代动力学特征
Rui Yao,Fuxin Han,Xiaoju Zhang
Rui Yao
6-Hydroxykaempferol-3,6-diglucoside is an important flavonoid constituent of Carthamus tinctorius L., with potential antioxidant and myocardial protective effects. However, its pharmacokinetic characteristics in normal and diabetic cardiomy...
Correction to "Exploring the Pharmacological Mechanisms of Xiaochaihu Tang in Treating Postmenopausal Osteoporosis: A Study Based on Network Pharmacology and Experimental Validation" [0.03%]
小柴胡汤治疗绝经后骨质疏松症药理机制的补遗：基于网络药理学及实验验证的研究
Published Erratum
Biomedical chromatography : BMC. 2026;40(7):e70488. DOI:10.1002/bmc.70488 2026
Combining Online HPLC-ABTS Screening With Machine Learning to Predict the Bioactivity of Antioxidant Components in Pandani Tectorii Radix et Rhizoma [0.03%]
基于HPLC-ABTS联用筛选结合机器学习预测潘大尼根及根茎抗氧化成分生物活性
Shu-Zhen Chen,Yong-Lin Ma,Dong-Xiao Li et al.
Shu-Zhen Chen et al.
This study developed an online HPLC-ABTS method to screen antioxidant phenolic acids in Pandani tectorii radix et rhizoma (PT) from 20 geographical origins. Six common constituents were screened and assigned by standards: neochlorogenic aci...
Comprehensive Analytical Method Development for Related Substance Determination in Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solutions: Multi-Method Approach and Regulatory Compliance [0.03%]
多佐胺盐酸盐-美开朗马来酸盐眼科溶液的全方位相关物质测定分析方法开发：多种方法途径及符合法规要求
Ramakrishna Kapavarapu,Srujan Kumar Mantena
Ramakrishna Kapavarapu
This study presents the development and validation of three selective chromatographic methods for the identification and quantification of related substances, including process-related impurities and degradation products, in combined ophtha...
Simultaneous Determination of Amlodipine and Naringin in Rat Plasma by LC-MS: Method Development and Validation [0.03%]
LC-MS法同时测定氨氯地平和柚皮素在大鼠血浆中的含量：方法的建立及验证
Vishala Rani Baraily,Bhupendra Shrestha,Sunanda Tuladhar et al.
Vishala Rani Baraily et al.
Naringin, a citrus flavanone glycoside, inhibits CYP3A4 and P-glycoprotein, making it a clinically relevant modulator of drug bioavailability. Amlodipine, a widely prescribed calcium channel blocker, metabolised by CYP3A4, is susceptible to...
UPLC Multiwavelength Quantification and PLS-DA Reveal Stir-Baking Degree-Dependent Marker Dynamics in Paeoniae Radix Alba [0.03%]
基于UPLC多波长定量及PLS-DA的白芍炮制品中标志物成分动态变化研究
Lixia Chen,Weiting Liang,Yonglin Guo et al.
Lixia Chen et al.
Paeoniae Radix Alba (PRA, roots of Paeonia lactiflora Pall.) yields stir-baked (sbPRA), charred (cPRA), and carbonized (caPRA) specifications through increasing degrees of stir-baking. In this study, an ultrahigh-performance liquid chromato...
Liquid Chromatographic Methods for Microsampling in Sports Drug Monitoring: Progress in DBS and VAMS [0.03%]
用于运动反兴奋剂检测微采样液相色谱法的发展：DBS和VAMS的进展
Chunli Zhang
Chunli Zhang
Sports drug monitoring has long relied on urine testing and, to a lesser extent, venous blood collection. Although this framework remains effective for many prohibited substances, it is increasingly challenged by demands for minimally invas...
Solvent-Dependent GC-MS and LC-MS/MS Phytochemical Profiling of Echium italicum L. Aerial Part Extracts and In Vitro Enzyme Inhibitory and DNA-Protective Effects [0.03%]
基于溶剂的ECHIUM ITALICUM L. 药理作用研究
İçim Gökkaya,Gökçe Seyhan,Elçin Güney et al.
İçim Gökkaya et al.
Echium italicum is a medicinal plant traditionally used in Türkiye for wound healing and inflammatory conditions. In this study, chloroform, ethyl acetate, ethanol, and 70% ethanol extracts prepared from the aerial parts were comparatively...