Validation of an LC-MS/MS method for assessment of fenbendazole sulfone drug residue in northern bobwhite liver [0.03%]
高效液相色谱-质谱法测定白喉鹤肝组织中芬苯达唑砜残留量的方法学验证
Brett J Henry,Dhavalkumar Patel,Cassandra Henry et al.
Brett J Henry et al.
The Northern Bobwhite (Colinus virginianus) is an economically important game bird within the Rolling Plains Ecoregion. Within this region, bobwhite is experiencing extreme cyclic population fluctuations which are resulting in a net decline...
Study on the opening effect of eucalyptol on the blood-brain barrier and its brain pharmacokinetics [0.03%]
吴茱萸烯开启血脑屏障效应的研究及其脑药动学研究
Ligema Dao,Li Jiang,Yuanyuan Chen et al.
Ligema Dao et al.
Eucalyptol, a natural epoxide monoterpene, was found in rat brain tissue after oral administration in our previous study, suggesting that the compound may possess the ability to pass the blood-brain barrier (BBB). However, a few studies hav...
A review of various analytical methods for the estimation of olanzapine: An antipsychotic drug [0.03%]
奥氮平的多种分析方法概述及评价：一种抗精神病药物
Reka S,Afsana Sheikh,Waleed H Almalki et al.
Reka S et al.
Olanzapine (OLZ) is an antipsychotic agent and is a thienobenzodiazepine derivative. It is used either in combination with other drugs like carbamazepine, simvastatin, and clozapine or as a single drug. The present work is mainly focused on...
A RP-HPLC-DAD method for analysis of Brazilian southeast brown propolis and its leishmanicidal properties [0.03%]
一种分析巴西东南部褐色プロポリス及其莱什曼氏病细胞毒性作用的RP-HPLC-DAD法
Victor Pena Ribeiro,Jennyfer Andrea Aldana-Mejia,Caroline Arruda et al.
Victor Pena Ribeiro et al.
Propolis is a natural product of great economic and pharmacological importance. The flora surrounding the bee communities is a determining factor in the composition of propolis and therefore in its biological and medicinal properties. Brown...
Dried blood spots for doping controls-Development of a comprehensive initial testing procedure with fully automated sample preparation [0.03%]
用于兴奋剂检测的干血斑检测方法——具有全自动样品准备功能的全面初步检测程序的研发
Ann-Marie Garzinsky,Andreas Thomas,Sven Guddat et al.
Ann-Marie Garzinsky et al.
Currently, primarily urine, whole blood and serum samples are analyzed for doping-relevant substances in professional sports, but recently dried blood spots (DBS) have been introduced as complementary matrix, offering advantageous features,...
Identification of the anti-inflammatory quality markers of Chrysanthemi Flos (Juhua) using spectrum-effect relationships combined with bioactivity re-evaluation [0.03%]
基于谱效关系联合活性再评价的菊花抗炎质量标志物识别研究
Dan Liu,Qianqian Zhu,Lian Zhang et al.
Dan Liu et al.
Chrysanthemi Flos (Juhua), an edible herbal medicine that possesses efficacies of dispersing wind, clearing heat and detoxifying. Studies have demonstrated that the health benefits of Chrysanthemi Flos are largely attributable to its anti-i...
Establishment and validation of a sensitive LC-MS/MS method for the quantification of KRASG12C protein PROTAC molecule LC-2 in rat plasma and its application to in vivo pharmacokinetic studies of LC-2 PEGylated liposomes [0.03%]
一种用于定量KRASG12C蛋白PROTAC分子LC-2的敏感LC-MS/MS方法的建立及其在PEG修饰脂质体包裹LC-2体内药代动力学研究中的应用
Yu Wang,Zhiyu Wang,Xiaowen Wang et al.
Yu Wang et al.
LC-2, is a molecule of proteolysis targeting chimeras (PROTACs), with a large molecular weight, poor water solubility and low system bioavailability, which was designed to degrade KRASG12C protein. In this study, LC-2 PEGylated liposomes we...
Widely targeted metabolomics analysis reveals the differences in nonvolatile compounds of citronella before and after drying [0.03%]
广泛目标代谢组分析揭示了香茅在干燥前后的非挥发性化合物差异
Yun Xiong,Peijie Ma,Yitong Yan et al.
Yun Xiong et al.
Citronella is used as a spice and a traditional herbal medicine. Dried citronella is easy to store and transport, and it is unclear whether dried citronella has more or fewer medicinal components compared to fresh citronella. In the present...
Development and validation of an HPLC-MS/MS method to simultaneously quantify brigatinib, lorlatinib, pralsetinib and selpercatinib in human K2-EDTA plasma [0.03%]
一种同时定量人类K2-EDTA血浆中brigatinib，lorlatinib，pralsetinib和selpercatinib的方法的开发与验证
Judith L Gulikers,Ard J van Veelen,Elishia M J Sinkiewicz et al.
Judith L Gulikers et al.
A liquid chromatography-tandem mass spectrometry method was developed and validated to quantify the small-molecule inhibitors (SMIs) brigatinib, lorlatinib, pralsetinib and selpercatinib, which are used in patients with oncogenic-driven non...
A novel anastrozole intravaginal ring for endometriosis: Pharmacokinetic characteristics and mucosal irritation [0.03%]
一种用于子宫内膜异位症的新型他莫昔芬阴道环：药代动力学特征和粘膜刺激性
Zixia Yang,Jian Dong,Siyi Wu et al.
Zixia Yang et al.
In order to achieve the long-term management of endometriosis, a more economical and environmentally friendly material, ethylene vinyl acetate (EVA), was used to prepare a intravaginal ring with anastrozole (ATZ). This paper has compared th...