Yamiao Fan,Linchen Ji,Tianqi Wang et al.
Yamiao Fan et al.
Cadmium (Cd) is a toxic heavy metal that accumulates in organisms and threatens health via the food chain. The kidney is a key target organ for Cd toxicity. Ferroptosis, a novel form of cell death distinct from apoptosis, necrosis, and auto...
Monocrotophos-Induced Oxidative Stress Disrupts Locomotion and Metabolic Function in Drosophila melanogaster [0.03%]
单环虫毒磷诱导的氧化应激会破坏果蝇(Drosophila melanogaster)的运动和代谢功能
Kanchana Das,Abhratanu Ganguly,Sayantani Nanda et al.
Kanchana Das et al.
The study unveils potential toxic effects of a widespread organophosphate pesticide, monocrotophos, in a non-target model organism Drosophila melanogaster. Monocrotophos has been used in cotton, sugarcane, and paddy fields for many decades....
β-Sitosterol Restored Intestinal Barrier Integrity and Reduced Intestinal Hypermotility in Stress-Induced IBS: Comparison With Sertraline [0.03%]
β-谷固醇恢复应激诱导的肠易激综合症(IBS)小鼠的肠道屏障功能及减少肠道高动力：与舍曲林对比研究
Sepideh Hajivand,Mohammadreza Sharifi,Ardeshir Talebi et al.
Sepideh Hajivand et al.
Irritable bowel syndrome (IBS) is characterized by visceral hypersensitivity, intestinal hypermotility, and impaired barrier integrity. This study evaluated the effects of β-sitosterol and sertraline on colonic motility, tight junction pro...
Zebularine Boosts Imatinib Efficacy in Cells of Colorectal Cancer via Wnt-Survivin-P-Glycoprotein Pathway [0.03%]
泽来替尼通过Wnt-survivin-P-糖蛋白途径增强伊马替尼对结直肠癌细胞的疗效
Yasmin M Attia,Abeer Elkhoely,Fatma M Abdelwahed et al.
Yasmin M Attia et al.
Colorectal cancer (CRC) remains one of the leading causes of cancer mortality, with a poor survival rate of less than 15%. Imatinib (IM) and Zebularine (ZEB) alone have shown potential effects in CRC treatment, but their combination has not...
In Vitro Studies on Induction of Ferroptosis Upon Low-level Exposure of Bisphenol A on Rat Erythrocytes [0.03%]
双酚A低剂量暴露诱导大鼠红细胞铁死亡的体外研究
M Naga Vaishnavi,Nidhi Srivastava,Ankita Sharma
M Naga Vaishnavi
Bisphenol A (BPA), is a xenoestrogen used in plastic manufacturing companies. Some countries are limiting the use of BPA. The widespread use of BPA has resulted in its accumulation in the natural environment. This compound is extensively ut...
miR-371a-3p Overexpression Alleviates Cognitive Dysfunction Via Targeted Negative Regulation of FKBP5 [0.03%]
miR-371a-3p过表达通过靶向负调控FKBP5缓解认知障碍
Zhenzhen Sun,Yanyan Sun,Yaqi Guo et al.
Zhenzhen Sun et al.
The study aims to explore the role of miR-371a-3p in cognitive dysfunction and its underlying mechanisms. This research comprised 143 elderly orthopedic patients undergoing anesthesia. They were further categorized into POCD and NPOCD group...
Potential of Caffeic Acid in Combating Aluminum and Beryllium Induced Oxidative Injury in Multiorgan: Insight From Hematology, Biochemistry and Histology in Rats [0.03%]
氯ogenic酸在对抗铝和铍诱导的多器官氧化损伤中的潜力：来自大鼠血液学、生化及组织病理学的见解
Pavitra Behra,Pratima Dutta,Anurag Singh et al.
Pavitra Behra et al.
Metal contamination poses a significant health concern driven by industrialization, landscape modifications, and rapid urbanization. Aluminum and beryllium exposure has been associated with multiple organ dysfunction, including liver, kidne...
Flavokawain A Mitigates Mycoplasma pneumoniae-Induced Pneumonia by Inhibiting ERK/JNK/NF-κB Pathway in a Mouse Model [0.03%]
flavokawain A通过抑制erk/jnk/nf-κb信号通路缓解我的支原体感染的小鼠肺炎
Helong Zhou,Fatimah S Al-Khattaf,Anis Ahamed et al.
Helong Zhou et al.
Pneumonia, a respiratory infection that primarily affects the lungs, is a significant health concern in the pediatric population, often leading to hospitalization and, in severe cases, mortality. The present study was performed to investiga...
Ameliorative Effects of Quercetin on Tartrazine-Induced Hepatotoxicity in Rats: Insights Into Body Weight, Caspase Signaling, Cytokine Storm, Oxidative Stress, and Hepatocellular Proliferation [0.03%]
槲皮素改善 tartrazine 致大鼠肝毒性：对体重、半胱天冬酶信号转导、细胞因子风暴、氧化应激及肝细胞增殖的洞察
Bülent Aylaz,Zeynep Erdemli,Mehmet Gul et al.
Bülent Aylaz et al.
Protective role of Quercetin against the possible harmful effects of Tartrazine, which is widely used. These doses have been studied for the first time in the literature. Rats were divided: Control, Tartrazine, Quercetin, and Tartrazine + Q...
Protective Effect of Saroglitazar Against Acute Lung Injury Induced by LPS in Rats [0.03%]
沙罗昔帕对内毒素致大鼠急性肺损伤的保护作用
Marina R Francis,Ahmed R El-Sheakh,Ghada M Suddek
Marina R Francis
Sepsis-induced acute lung injury (ALI) is a grave pathological syndrome correlated with high morbidity and fatality rates. This experiment investigated the prophylactic impact of saroglitazar (SAR) against acute lung injury induced through ...