Hesperidin Methyl Chalcone Inhibits Hallmarks of Cancer by Targeting the AKT, PI3K/GSK-3β/β-Catenin/STAT3 Signaling Axis in Oral Squamous Cell Carcinoma Models [0.03%]
桔皮素甲基查尔康因通过靶向PI3K/GSK-3β/β-连环蛋白/STAT3信号轴抑制口腔鳞状细胞癌模型的癌症标志物
Saranya Jawaharlal,Ramachandhiran Duraisamy,Vinothkumar Veerasamy
Saranya Jawaharlal
Oral squamous cell carcinoma (OSCC) is the most prevalent and drug-resistant cancer. We studied the chemopreventive effects of Hesperidin Methyl Chalcone (HMC) on DMBA-induced hamster buccal pouch carcinogenesis (HBPCs). Male golden Syrian ...
Diacerein Ameliorates Gentamicin-Induced Nephrotoxicity via Regulating PI3k/AKT-Mediated Nrf-2 and NF-κB Pathways: Forge the Mechanistic Insight [0.03%]
二氯醋酸二异丙胺通过调节PI3K/AKT介导的Nrf-2和NF-κB信号通路改善庆大霉素诱导的肾毒性：为机制见解提供证据
Heba A Habib,Gehan H Heeba,Rania Abdel-Latif
Heba A Habib
Nephrotoxicity is one of the most significant therapeutic limitations of gentamicin (GM) antibiotics, strongly linked to oxidative stress and apoptotic pathways. In this study, diacerein (DIA), an antiarthritic agent with potent antioxidant...
Posttranscriptional Regulation of Metabolism in Glioblastoma: A Multipathway Review [0.03%]
胶质母细胞瘤代谢的转录后调控：多通路综述
Suleiman Ibrahim Mohammad,Asokan Vasudevan,Favian Bayas Morejón et al.
Suleiman Ibrahim Mohammad et al.
Glioblastoma (GBM) is the most aggressive and lethal form of primary brain tumor. A hallmark of GBM metabolism is the Warburg effect, whereby tumor cells preferentially utilize aerobic glycolysis despite oxygen availability, producing ATP i...
Molecular Docking and Experimental Evaluation of Trolox and Neocuproine in Targeting Neuroinflammation in Neuropathic Pain Model [0.03%]
基于分子对接的Trolox和Neocuproine抗神经炎症作用研究及痛模型中的实验验证
Selma Yaman,Güven Akcay,Fatma Yesilyurt et al.
Selma Yaman et al.
This study was carried out to evaluate the therapeutic efficacy of Neocuproine/Trolox treatment on chronic neuropathy induced by Chronic Constriction Injury (CCI). Rats (n = 40) were grouped as Sham, CCI, CCI+Trolox, and CCI+Neocuproine. Ra...
Molecular Mechanisms Involved in the Pathophysiology of Sepsis: Role of Signaling Pathways [0.03%]
参与脓毒症病理生理的分子机制：信号通路的作用
Seher Yilmaz,Şükrü Ateş,Sümeyye Uçar et al.
Seher Yilmaz et al.
Sepsis is characterized as an aberrant and dysregulated physiological reaction to infection, resulting in severe and potentially fatal organ impairment. Globally, it poses a substantial public health burden, with nearly 48.9 million inciden...
Anti-Neuroinflammatory and Neuroprotective Effects of Caffeic Acid in Experimental Models of Neurodegeneration: A Systematic Review and Meta-Analysis [0.03%]
咖啡酸在神经退行性病变实验模型中的抗神经炎症和神经保护作用的系统评价和meta分析
Radhika Bhat,Alosh Greeny,Gollapalle Lakshminarayanashastry Viswanatha et al.
Radhika Bhat et al.
Caffeic acid, a naturally occurring polyphenol found in various dietary sources, has gained considerable interest for its antioxidant, anti-inflammatory, and neuroprotective properties. Preclinical studies suggest that caffeic acid may exer...
Exosomes as Biomimetic Nanoplatforms for Synergistic Targeted Chemotherapy and Photothermal Treatment of Breast Cancer [0.03%]
乳腺癌的协同靶向化疗和光热治疗的类仿生纳米平台外泌体研究
Harsha Sanil,Valliyodu Revathi,Sufina Sudhina et al.
Harsha Sanil et al.
Breast cancer remains the most common cancer in women worldwide, with approximately 2.3 million new cases and 685,000 deaths annually (WHO, 2024). Triple-negative breast cancer (TNBC), the most aggressive subtype, has < 15% 5-year survival ...
N-Acetylcysteine Attenuates Mancozeb-Induced Hepatorenal Injury by Modulating Oxidative Stress, Inflammatory Signaling, and Apoptotic Pathways in Rats [0.03%]
N-乙酰半胱氨酸通过调节氧化应激、炎症信号和凋亡途径减轻曼祖布诱导的大鼠肝肾损伤
Ali Çakırlı,Metin Deniz Karakoç,Özlem Özmen et al.
Ali Çakırlı et al.
Mancozeb (MNZ), a widely used dithiocarbamate fungicide, has been associated with oxidative stress-mediated organ toxicity in nontarget species. The present study investigated the potential protective effects of N-acetylcysteine (NAC) again...
Natural Products and Long Noncoding RNAs: A Complex Regulatory Network in Pancreatic Cancer Progression and Treatment [0.03%]
天然产物和长链非编码RNA：在胰腺癌发展及治疗中的复杂调控网络
Hanan Elimam,Abdullah F Radwan,Nourhan Elfar et al.
Hanan Elimam et al.
Pancreatic cancer (PC) is among the most lethal malignancies, characterized by late-stage diagnosis, limited treatment options, and high therapeutic resistance. Growing evidence indicates that long noncoding RNAs (lncRNAs) are key regulator...
Alpha-Tomatine Inhibits Human Oral Epidermoid Carcinoma Cells Through DNA Damage and Activation of Apoptotic Signaling Pathways [0.03%]
α-番茄碱通过dna损伤和凋亡信号途径抑制人类口腔鳞状细胞癌细胞生长
Nihal Ahamed Abulkalam Azad,Suresh Kathiresan,Theerthu Azhamuthu et al.
Nihal Ahamed Abulkalam Azad et al.
Oral cancer still poses a serious threat to world health and has limited feasible remedies. Recently, Alpha-tomatine (AT), a naturally occurring glycoalkaloid, has attracted attention due to its possible anticancer effects. The study invest...