Feselol Ameliorates Acetaminophen-Induced Hepatotoxicity Through Multi-Pathway Modulation of Oxidative Stress, Inflammation, and Apoptosis in Mice [0.03%]
菲塞醇通过多通路调节氧化应激、炎症和凋亡缓解小鼠 acetaminophen 诱导的肝毒性
Maryam Karimi-Dehkordi,Firoozeh Saghaei,Mohammad Saberian et al.
Maryam Karimi-Dehkordi et al.
Background and aim: Acetaminophen (APAP) overdose is a major cause of drug-related acute liver failure around the world. The limited treatment options beyond N-acetylcysteine (NAC) show a clear need for new liver-protecti...
Antiemetic Efficacy of Esculetin via Dopaminergic, Serotonergic, and Muscarinic Pathway Modulation: Insights From In Vivo and In Silico Studies [0.03%]
esculetin的止吐功效通过多巴胺能，血清素能和毒蕈碱通路调节：体内和体外实验研究的新见解
Afiya Ajmee,Anike Chakrabarty,Chinmoy Kumar Saha et al.
Afiya Ajmee et al.
Esculetin (ELN), a naturally occurring coumarin derivative, possesses a range of pharmacological activities, yet its antiemetic potential remains underexplored. This study assessed the efficacy of ELN against copper sulfate pentahydrate (Cu...
Chrysin Inhibited Aß25-35 Induced IL-17 Receptor Signalling Through Act1-TRAF6-NF-κB Axis in Rat Peripheral Blood Mononuclear Cells [0.03%]
染料木素通过Act1-TRAF6-NF-κB信号轴抑制黄酮Aβ25-35诱导的外周血单个核细胞中IL-17受体信号转导
Avtar Singh Gautam,Rakesh Kumar Singh
Avtar Singh Gautam
Alzheimer's disease (AD) is the most prevalent form of age-related dementia, preceded by a prodromal period. The key pathological factor of AD is chronic excessive brain amyloid-beta (Aβ) aggregation, and it occurs much before the initial ...
Isoliquiritigenin, Nrf2 Activator, and NLRP3 Inhibitor Protects Isoniazid-Induced Hepatotoxicity in Sprague-Dawley Rats: Studies on Oxidative Stress, Inflammation, DNA Damage, Ferroptosis, and Steatosis [0.03%]
异甘草素通过激活Nrf2和抑制NLRP3保护异烟肼致大鼠肝毒性：氧化应激、炎症、DNA损伤、铁死亡和脂肪变性的研究
Gurpreet Singh,Mohammad Aabis,Vaishali Maurya et al.
Gurpreet Singh et al.
Isoniazid (INH), a widely used first-line anti-tubercular drug, has significant concern for the hepatotoxicity in humans induced by oxidative stress, inflammation and steatosis. INH activates NLRP3 inflammasome and inhibits Nrf2 activation ...
LncRNA HOXB-AS1 Accelerates Epithelial Ovarian Cancer Progression by Modulating the miR-671-5p/SPTBN2 Axis [0.03%]
长链非编码RNAHOXB-AS1通过调节miR-671-5P/SPTBN2轴促进上皮性卵巢癌进展
Chao He,Wenying Peng,Xuyue Jia et al.
Chao He et al.
Epithelial ovarian cancer has the characteristics of high malignancy and poor survival outcomes. Long non-coding RNAs (lncRNAs) can mediate the biological function through regulating the expression of miRNA or protein in cancers. This study...
Obeticholic Acid and Methyl Ferulic Acid Mitigate Arsenic Trioxide-Induced Hepatotoxicity by Targeting Profibrotic and Proinflammatory Signaling [0.03%]
奥贝胆酸和甲基阿魏酸通过靶向促纤维化和促炎信号缓解三氧化二砷诱导的肝毒性
Souty M Z Sharkawi,Elshaimaa A Arafa,Ehab A M El-Shoura et al.
Souty M Z Sharkawi et al.
Arsenic, a toxic environmental metalloid, induces liver damage by activating oxidative stress, inflammation, and apoptosis. This study examined the potential ameliorative effects of obeticholic acid (OCA) and methyl ferulic acid (MFA) again...
Targeting Cancer Through Oxidative Stress: The Role of Epigallocatechin Gallate in Reactive Oxygen Species Modulation [0.03%]
通过氧化应激针对癌症：表没食子儿茶素没食子酸酯在活性氧调节中的作用
Emon Mia,Md Arif Hossain,Mohammad Y Alshahrani et al.
Emon Mia et al.
Epigallocatechin gallate (EGCG), a major polyphenol found in green tea, has emerged as a promising candidate due to its diverse pharmacological properties, particularly its role in modulating reactive oxygen species (ROS). The objective of ...
Histone Deacetylase 7 Exacerbates the Inflammatory Response by Inhibiting Nur77 Expression to Induce Lesions of Acute Respiratory Distress Syndrome [0.03%]
组蛋白脱乙酰酶7通过抑制Nur77表达加重炎症反应诱导急性呼吸窘迫综合征病变
Dongdong Yang,Rong Zhou,Chenjuan Wang et al.
Dongdong Yang et al.
Acute respiratory distress syndrome (ARDS) is an acute respiratory disease. Nuclear receptor 77 (Nur77) shows anti-ARDS activity. Histone deacetylase 7 (HDAC7) knockdown suppresses inflammatory response in acute lung injury, but its role in...
Remimazolam Inhibits Neuronal Apoptosis, Inflammation, and Ferroptosis in Cerebral Infarction via Promoting TRIM67-Mediated Degradation of ACSL4 [0.03%]
瑞马唑仑通过促进TRIM67介导的ACSL4降解抑制脑梗死后神经元凋亡、炎症和铁死亡
Gaopeng Xiao,Yongqin Zhang,Ji Yang et al.
Gaopeng Xiao et al.
Cerebral infarction is one of the most common ischemic cerebrovascular diseases that can lead to neurological deficits. Remimazolam (RE) is a sedative agent that has been shown to improve neurological disorders. However, the underlying mole...
Multi-Omics and Functional Analyses Identify let-7b-3p as a Negative Regulator of EMT in Lung Adenocarcinoma [0.03%]
多组学和功能分析鉴定出let-7b-3p为肺腺癌中EMT的负调控因子
Donghong Zhang,Mengyao Wang,Li Li et al.
Donghong Zhang et al.
Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC), and its malignant progression involves complex molecular mechanisms. While microRNAs (miRNAs) play a crucial regulatory role in LUAD development, t...