Contrasting Effects of HT-2 Toxin Exposure and ZIP6 Knockdown on Chondrocyte Extracellular Matrix Metabolism [0.03%]
HT-2毒素暴露和ZIP6敲低对软骨细胞外基质代谢的相反影响
Yang Liu,Yu Zhang,Ruitian Huang et al.
Yang Liu et al.
Kashin-Beck disease (KBD) is a chronic, endemic osteoarticular disorder associated with T-2 toxin exposure, which is rapidly metabolized to HT-2 toxin in vivo. However, the role of zinc transporter ZIP6 in HT-2 toxin-induced extracellular m...
Hsa_circ_0044097 Serves as a Promising Biomarker of Atherosclerosis and Its Effects on Vascular Smooth Cell Proliferation and Migration [0.03%]
Hsa_circ_0044097可作为动脉粥样硬化的重要生物标志物及其对血管平滑肌细胞增殖和迁移的影响
Cencen Ren,Yungen Jiao
Cencen Ren
Atherosclerosis (AS) is closely related to the pathogenesis and abnormal proliferation and migration of vascular smooth muscle cells (VSMCs). To explore the value of hsa_circ_0044097 in the clinical management of AS and to elucidate its rol...
Apigenin, Selenium, and Combinations Are Effective in Preventing 5-Fluorouracil Induced Cardiovascular Damage [0.03%]
染料木素、硒及其组合可有效预防5-氟尿嘧啶引起的心血管损伤
Gözde Atila Uslu,Hamit Uslu,Taha Abdulkadir Çoban et al.
Gözde Atila Uslu et al.
Although chemotherapy is still a widely used primary treatment modality for many cancers, it is an accepted fact that it causes many undesirable side effects and toxicity. Until a new, side-effect-free treatment modality is developed, new r...
Rupatadine Ameliorates Cisplatin-Induced Hepatotoxicity in Rats: Targeting HMGB1/TLR4/NF-κB and NLRP3/Caspase-1 Signaling Pathways [0.03%]
鲁帕他定改善顺铂诱导的大鼠肝毒性：靶向HMGB1/TLR4/NF-κB和NLRP3/Caspase-1信号通路
Shaimaa Mohamed Abdelrahman,Amany Abdlrehim Bekhit,Olivia N Beshay
Shaimaa Mohamed Abdelrahman
Despite cisplatin (CISP) is broadly employed in cancer therapy, its adverse effects, involving hepatotoxicity, restrict its clinical usage. Thus, this study was designed to explore the prospect of repurposing rupatadine (RUPA), a dual antag...
Sex-Specific Anti-Inflammatory Effects of Alternate Day Fasting via TLR4 and Leptin Signaling in Middle-Aged Rats [0.03%]
交替日斋戒通过TLR4和瘦素信号通路在中年大鼠中产生性别特异性的抗炎效果
Ozgen Kilic-Erkek,Gulsah Gundogdu,Abdullah Coguplugil et al.
Ozgen Kilic-Erkek et al.
Alternate-day fasting (ADF) may exert age-related anti-inflammatory effects by modulating key metabolic and immune pathways. This study aimed to investigate the sex-specific effects of ADF on inflammation in middle-aged male and female rats...
SDCBP Cooperates With YBX1 to Promote ESCC Metastasis by Forming a Positive Feedback Loop With Wnt-β-Catenin Signaling Pathway [0.03%]
SDCBP通过与YBX1合作形成正反馈机制以促进食管鳞癌转移
Ruijuan Du,Bo Bian,Manyu Luo et al.
Ruijuan Du et al.
Syndecan binding protein (SDCBP) has been shown to be upregulated in esophageal squamous cell carcinoma (ESCC) and predicts poor prognosis in our previous research. SDCBP stimulated the proliferation and tumor formation and may be a target ...
ATP7A Orchestrates Tumor Progression and Cuproptosis in Hepatocellular Carcinoma via the LINC02038-miR-506-3p Regulatory Circuit [0.03%]
LINC02038-miR-506-3P调控环介导的ATP7A orchestration在肝细胞癌肿瘤进展和铜死亡中的作用
Zhe Liu,Weixi Shan,Wenyu Zhou et al.
Zhe Liu et al.
Hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment options, underscoring the urgent need for novel therapeutic targets. The copper transporter ATP7A has been implicated in cancer, but its precise role and regulator...
β-Elemene Triggers Drp1-Dependent Mitochondrial Fission Through CDK1/Cyclin B1 Signaling in Cervical Cancer Cells [0.03%]
β-艾叶素通过CDK1/Cyclin B1信号触发Drp1依赖的线粒体分裂在宫颈癌细胞中的作用
Zhifang Li,Ling Tang,Mingyan Wang et al.
Zhifang Li et al.
Mitochondrial dynamics, regulated by fission and fusion, are frequently altered in cancers, influencing cell survival and metabolism. The sesquiterpene β-elemene exhibits anti-tumor activity, but its effect on mitochondrial dynamics in cer...
Morroniside Attenuates Doxorubicin-Induced Cardiotoxicity by Activating the PI3K/AKT/Nrf2/HO-1 Pathway to Inhibit Ferroptosis and Oxidative Stress [0.03%]
毛知丁素通过激活PI3K/Akt/Nrf2/HO-1信号通路抑制铁死亡和氧化应激从而减轻阿霉素致心脏毒性
Zhi-Hui Lin,Xing-Yu Lin,Wen-Jie Lu et al.
Zhi-Hui Lin et al.
Cardiotoxicity induced by doxorubicin (Dox) significantly contributes to increased mortality among cancer patients, yet available pharmacological interventions remain scarce. Recent studies suggest that ferroptosis is a key mechanism in the...
Targeting of Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) Signaling Pathway in Age-Related Eye Diseases: Molecular Mechanisms and Opportunities for therapy [0.03%]
核因子E2相关因子2（ NRF2）信号通路在年龄相关性眼病中的作用：分子机制及治疗前景
Fu XinYu,Luo Yi,Zhang Liu
Fu XinYu
Age-related eye diseases (AREDs), such as diabetic retinopathy (DR), cataract, glaucoma, age-related macular degeneration (AMD), presbyopia, and represent the primary sources of vision impairment globally. Numerous investigations have indic...