Cryptotanshinone Inhibits Staphylococcus aureus-Induced Mastitis by Inhibiting Ferroptosis Through Activating Nrf2/GPX4 Pathway [0.03%]
Cryptotanshinone通过激活Nrf2/GPX4途径抑制铁死亡治疗金黄色葡萄球菌诱导的乳腺炎
Zimeng Liu,Yunpeng Gao,Musen Li et al.
Zimeng Liu et al.
Mastitis is a prevalent gynecological disorder in women, with Staphylococcus aureus (S. aureus) serving as a primary etiological pathogen of this condition. Cryptotanshinone (CPT) has been demonstrated to exert anti-oxidative stress and ant...
Thymol Attenuates Klebsiella pneumoniae Induced Lung Injury via Modulation of Peroxidase-Driven Oxidative Stress and Host-Pathogen Interactions: In Vivo and In Silico Insights [0.03%]
百里酚通过调节氧化应激和宿主病原体相互作用减轻克雷伯氏菌引起的肺损伤：体内和计算机模拟研究见解
Meriem Amarni,Amina Ladjel-Mendil,Fawzi Allala et al.
Meriem Amarni et al.
Klebsiella pneumoniae pneumonia drives excessive inflammatory and oxidative responses that culminate in acute lung injury (ALI) and impaired bacterial clearance. Effective therapies capable of restoring host-pathogen balance remain limited,...
Synthesis, Characterization, Antioxidant Evaluation, Cytotoxicity Studies, and Molecular Docking of Novel Sulfonamide Derivatives [0.03%]
新型磺胺衍生物的合成、表征、抗氧化评价、细胞毒性研究及分子对接
Ouissal Bouraoui,Güldeniz Şekerci,Khaled Mesbah et al.
Ouissal Bouraoui et al.
A series of novel sulfonamide derivatives (4a-i) was synthesized via a three-step sequence involving Schiff base formation, sodium borohydride reduction to the corresponding secondary amines (2a-i), and subsequent treatment with p-toluenesu...
2-Pyrazoline-5-One Derivative Suppresses Cell Proliferation and Induces Apoptosis With Upregulation of Bax in Breast Cancer Cells [0.03%]
一种2-吡唑啉衍生物通过上调BAX蛋白在乳腺癌细胞中发挥抑瘤和促凋亡作用
Sevgi Kocyigit Sevinc,Ş Güniz Küçükgüzel,Sevim Rollas et al.
Sevgi Kocyigit Sevinc et al.
The most common cancer in women worldwide is still breast cancer. Among its subtypes, luminal A and triple-negative breast cancers present significant therapeutic challenges due to intrinsic drug resistance and absence of effective targeted...
Polydatin as a Mixed-Type Inhibitor of CYP1B1: An Integrative Study Combining Enzymatic Assays and Molecular Simulations [0.03%]
姜黄素茋通过酶动力学和分子模拟研究的混合机制抑制CYP1B1
Liwei Jia,Lei Zhou,Jinyue Lu et al.
Liwei Jia et al.
Cytochrome P450 1B1 (CYP1B1) is often upregulated in tumor tissues, whereas its expression in many normal tissues is relatively low. This expression pattern makes CYP1B1 a possible enzymatic target in cancer-related studies. Polydatin posse...
Carboplatin Elicits ROS Responses and Potentially Regulates Translation Program in Cancer Systems [0.03%]
卡铂诱导ROS反应并可能调节癌症系统的翻译程序
Qin Li,Si Qin,Liuxin Yang et al.
Qin Li et al.
Platinum-based chemotherapeutic agents display broad-spectrum and high anticancer activity, the primary target of which is nuclear DNA. During platinum chemotherapeutics, the steady-state levels of reactive oxygen species (ROS) are generall...
Cardioprotective Effect of Aloin Against Ischemia/Reperfusion Injury: Experimental and Computational POM Approaches [0.03%]
大黄素的护心作用对抗缺血再灌注损伤：实验和计算POM方法
Mounime Kadi,Taibi Ben Hadda,Faisal A Almalki et al.
Mounime Kadi et al.
This study investigates the antihypertensive, antioxidant, and cardioprotective effects of Aloin following Langendorff rat isolated heart technique, the main bioactive compound of Aloe vera L., using both experimental (The myocardial ischem...
Correlates of MAPK/Nrf2/STAT-3 Pathway Protein Expression With Morin Treatment in Helicobacter pylori-Infected Gastric Epithelial Cells-1 Cells: An Exploratory In Vitro Study [0.03%]
Morin对胃粘膜上皮细胞中MAPK/Nrf2/STAT-3信号通路相关蛋白表达的影响：一项体外实验性研究
Yanping Zhang
Yanping Zhang
Helicobacter pylori infection is a major risk factor for gastric cancer (GC), but the molecular mechanisms remain incompletely understood. This exploratory in vitro study investigated whether treatment with the flavonoid morin correlates wi...
Amelioration of Acrolein-Induced Cytotoxicity, Oxidative Stress, DNA Damage, Apoptosis and Mitochondrial Dysfunction in Human Pancreas Cells by Pycnogenol [0.03%]
法国松果提取物(PYC)改善丙烯醛诱导的细胞毒性和氧化应激以及人胰腺细胞中的DNA损伤、凋亡和线粒体功能障碍的作用
Zülal Atlı Şekeroğlu,Vedat Şekeroğlu,Şükrüye Kamanlı et al.
Zülal Atlı Şekeroğlu et al.
Acrolein (AC) is a potential environmental contaminant that poses a serious threat to human health and the environment. Studies on human diseases that can result from AC have rapidly increased in recent years. Pycnogenol (PYC), a natural ph...
Therapeutic Effect of Alpha-Lipoic Acid Against Hepatotoxicity Induced by Multi-Walled Carbon Nanotubes in Male Albino Rats [0.03%]
α-型乙酰辅酶A对抗多壁碳纳米管诱导的雄性大鼠肝毒性的作用效果研究
Esraa Emad El Dien,Yasmine H Ahmed,Yasmine A Mansour et al.
Esraa Emad El Dien et al.
Multi-walled carbon nanotubes (MWCNTs) are advantageous for several medical and industrial applications. Alpha-lipoic acid (ALA) is a potent antioxidant. This study aimed to investigate the efficacy of ALA in mitigating hepatotoxicity cause...