Cinnamaldehyde Attenuates Collagen-Induced Arthritis in Rats Through Immunomodulation and Alteration of Intestinal Flora Homeostasis and Repair of Intestinal Barrier Damage [0.03%]
肉桂醛通过免疫调节、改变肠道菌群平衡及修复肠屏障损伤干预胶原诱导型大鼠关节炎
Shuai Wang,Wanqing Dai,Yue Liu et al.
Shuai Wang et al.
Rheumatoid arthritis (RA) is a complex autoimmune disease, the present study aimed to investigate the effects of cinnamaldehyde (CA) on collagen-induced arthritis (CIA) in rats, with particular attention to changes in intestinal barrier-rel...
The Protective Effects of Crocin and Pentoxifylline, Alone and in Combination, in Alleviating Acrylamide-Induced Hepatic Injury in NMRI Mice [0.03%]
姜黄素和潘妥拉明单独或联合应用对NMRI小鼠丙烯酰胺致肝损伤的保护作用研究
Yaser Mohammadi,Reyhaneh Taebi,Elham Bahreini et al.
Yaser Mohammadi et al.
Acrylamide (ACR) is formed as a byproduct during high-temperature processing of carbohydrate-rich, low-protein foods and represents a widespread dietary contaminant. Given the extensive daily human exposure, its hepatotoxic potential is a g...
Inflammation and Stress: The Resemblance and Variance Between Atherosclerosis and Carcinogenesis-A Pilot Study [0.03%]
炎症与压力：动脉粥样硬化和癌变的相似性和差异性——一项试点研究
Varsha Suryan,Amit Kumar,Nimai Chand Chandra
Varsha Suryan
While atherosclerosis is a disease of vascular hypercholesterolemia, reports have also shown the presence of intracellular hypercholesterolemia in cancer tumor cells. Since the dietary cholesterol in the blood vessel is the major source of ...
Crocin Ameliorates Testicular Damage in Type 1 Diabetic Rats: Role of Akt-Mediated Nrf-2 Activation [0.03%]
小檗红碱改善1型糖尿病大鼠睾丸损伤：Akt介导的Nrf-2激活的作用机制研究
Gözdenur Güneş,Neslihan Akarsu,Serap Sancar et al.
Gözdenur Güneş et al.
Diabetes, a prevalent global concern, leads to severe complications, with an increasing number of diabetic individuals each year. Reproductive function disorders and infertility associated with diabetes primarily arises due to oxidative str...
Novel Cellular Signalling Axes in Neurodegenerative Diseases: From NLRP3 Inflammasome to Wnt/β-Catenin and Hippo-YAP Pathways [0.03%]
神经退行性疾病中的新型细胞信号轴：从NLRP3炎性体到Wnt/β-连环蛋白和Hippo-YAP通路
Kuldeep Singh,Iftakhar Ahmad,Divya Jain et al.
Kuldeep Singh et al.
Neurodegenerative diseases (NDs), including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's disease (PD), are characterised by impaired cellular homeostasis and progressive neuronal ...
Patulin Affects the Hydroxylation of Vitamin D by Downregulating 25-hydroxylase (CYP2R1) and 25-hydroxyvitamin D 1-alpha-hydroxylase (CYP27B1) Expression and Interfering Their Substrate Binding Sites [0.03%]
Patulin通过下调维生素D羟基化酶(CYP2R1和CYP27B1)表达及干扰其底物结合位点影响维生素D羟基化
Shangyun Lu,Jing Gao,Huixia Zhang et al.
Shangyun Lu et al.
Patulin (PAT) is a mycotoxin that grows on various fruits and grains, and its toxicity research mainly focuses on organ toxicity. However, the research on its impact on nutritional metabolism is still unclear. Vitamin D is an important nutr...
Circ_RPPH1/miR-326 Axis Blocks Chronic Stress-Promoted Progression and Metastasis of Lung Adenocarcinoma [0.03%]
环状RNA Circ_RPPH1/miR-326轴抑制慢性压力促进的肺腺癌进展和转移
Ying Xiang,Yangfeng Huang,Dan Zhao et al.
Ying Xiang et al.
Chronic stress resulted in poor prognosis of cancer patients in the clinic. This study aimed to explore the mechanism by which chronic stress promotes the progression of lung adenocarcinoma (LUAD) through circ_RPPH1/miR-326 axis. Chronic st...
SOX9, the Master Regulator of Lung Cancer, and a Therapeutic Approach [0.03%]
SOX9肺癌调控 master 调节因子与治疗策略
Yongli Chen,Xiaoming Meng,Yanling Chen et al.
Yongli Chen et al.
Dysregulation of transcription factors is a hallmark of lung tumorigenesis, and Sex-determining region Y-box 9 (SOX9) has emerged as a putative master regulator at the intersection of development and malignancy. Building on evidence from lu...
Indirubin Sensitizes Prostate Cancer to Docetaxel by Inhibiting Autophagy Through the circ-Vav3/miR-204-5p/MAPK1 Pathway [0.03%]
天青素通过circ-Vav3 / miR-204-5p / MAPK1轴抑制自噬增强前列腺癌对多西他赛的敏感性
Minghao Zheng,Gan Cai,Long Ma et al.
Minghao Zheng et al.
Accumulating evidence indicates that indirubin exerts inhibitory effects on prostate cancer (PCa) progression. However, the role and underlying mechanisms of indirubin in sensitizing PCa to docetaxel remain unclear. CCK-8 assays were initia...
Transcriptional Activation of SKA3 by SOX9 Promotes the Malignant Progression of Laryngeal Squamous Cell Carcinoma by Regulating AKR1C1 [0.03%]
SOX9通过调控AKR1C1转录激活SKA3促进喉部鳞状细胞癌恶性进展
Jing Peng,Zeying Pan,Yan Ruan et al.
Jing Peng et al.
Laryngeal squamous cell carcinoma (LSCC) is one of the most common types of head and neck cancer, posing a significant threat to public health. The spindle and kinetochore-associated complex subunit 3 (SKA3), a microtubule-binding subcomple...