Potential Therapeutic Effects of Chrysin and Apigenin in a Diethylnitrosamine-Induced Hepatocellular Carcinoma Rat Model [0.03%]
黄茋素和木犀草素对二乙基亚硝胺致肝癌大鼠的潜在治疗作用
Fatma Tedik,Nevin İlhan,Solmaz Bodur et al.
Fatma Tedik et al.
Hepatocellular carcinoma (HCC) is an aggressive cancer with poor prognosis and high mortality rates. The increasing mortality associated with HCC highlights the urgent need for alternative therapeutic approaches. Natural products and their ...
Transgenerational Effect of a Mixture of Pyrethroids in the Testis of Rats: A Transcriptome and Epigenome Analyses [0.03%]
拟除虫菊酯类农药混合物对大鼠睾丸的跨代效应：转录组与表观遗传学分析
Patra Priyadarshini Priyanka,Anandha Rao Ravula,Suresh Yenugu
Patra Priyadarshini Priyanka
Pyrethroids exert toxic effects on multiple organ systems, including the male reproductive tract. We previously demonstrated the toxicity of a mixture of pyrethroids in rats when administered at doses equivalent to human exposure. It is pos...
The Nephroprotective Effects of Nebivolol Against Cyclophosphamide-Induced Toxicity Occur via Antioxidant and Anti-Inflammatory Pathways [0.03%]
nebivorol的肾保护作用通过抗氧化和抗炎途径对抗环磷酰胺引起的毒性
Alessandra O Silva,João M R de Freitas,Cristopher M Carvalho et al.
Alessandra O Silva et al.
Cyclophosphamide is a chemotherapy drug used to treat various types of neoplasms and autoimmune diseases. During its hepatic metabolism, acrolein is formed, a toxic metabolite responsible for increasing oxidative stress in tissues such as t...
Vitexin Ameliorates HG-Induced Injury in Retinal ARPE-19 Cells by Targeting CASP3 [0.03%]
维特辛通过靶向CASP3改善高糖诱导的视网膜ARPE-19细胞损伤
Meng Wang,Guangwei Jiang,Xiangjun Meng et al.
Meng Wang et al.
Diabetic retinopathy (DR) stands as a common microvascular issue associated with diabetes mellitus, a condition defined by progressive structural decline in the retina. Although studies have reported that vitexin exhibits positive pharmacol...
Curcumin Attenuates Aroclor 1254-Induced Oxidative, Genotoxic, and Apoptotic Alterations in HepG2 Cells [0.03%]
姜黄素对Aroclor 1254诱导的HepG2细胞氧化、遗传毒性及凋亡损伤的抑制作用
Pınar Erkekoğlu,Selinay Başak Erdemli Köse,Hülya Tezel Yalçın et al.
Pınar Erkekoğlu et al.
Polychlorinated biphenyls (PCBs), particularly Aroclor 1254 (A1254), are persistent environmental contaminants with hepatotoxic, genotoxic, and pro-oxidant properties. The liver, as the main organ for xenobiotic metabolism, is highly vulner...
MYBL2 Knockdown Enhances Ferroptosis and Bortezomib Sensitivity by Transcriptionally Regulating CDKN3 and Inactivating PI3K/Akt Signaling in Multiple Myeloma [0.03%]
MYBL2敲低通过转录调控CDKN3和失活PI3K/Akt信号通路增强铁死亡和硼替佐米敏感性以抑制多发性骨髓瘤细胞生长
Ping Wang,Tian Liu,Xin Xiong et al.
Ping Wang et al.
MYBL2 is an oncogene that has been found to be upregulated in diverse cancers. However, the role of MYBL2 in multiple myeloma (MM) remains unclear. Here we used bioinformatic analysis to identify the differentially expressed genes in MM. In...
Curcumin Alleviates Methotrexate-Induced Neurobehavioral Deficits and Modulates the Redox-Inflammatory-Neurotrophic Axis in Mice [0.03%]
姜黄素通过调节红氧化-炎症-神经营养轴来缓解甲氨蝶呤致小鼠神经行为缺陷
Durmuş Ali Aslanlar,Mehmet Oz,Mehmet Emre Ay
Durmuş Ali Aslanlar
Methotrexate (MTX), a widely used chemotherapeutic agent, is associated with central nervous system toxicity characterized by oxidative stress, neuroinflammation, and behavioral disturbances. The present study investigated whether curcumin ...
Battling Parkinson's and Alzheimer's: The Neuroprotective Power of Carnosic Acid [0.03%]
肉碱酸的神经保护作用：对抗帕金森症和阿尔茨海默病
Ahsas Goyal,Aanchal Verma,Anshika Kumari et al.
Ahsas Goyal et al.
Neurodegenerative disorders have recently emerged as one of the most difficult worldwide health challenges. Neuronal cell injury is a major factor in neurodegenerative diseases. There seems to be rising interest in developing effective neur...
Sulfonamide Derivatives as Competitive Lactoperoxidase Inhibitors Through Integrated Experimental and Multi-Level Computational Analysis [0.03%]
基于集成实验和多尺度计算的硫胺衍生物竞争性乳过氧化物酶抑制剂研究
Kevser Kübra Kırboğa,Şükran Acar,Zeynep Köksal
Kevser Kübra Kırboğa
Lactoperoxidase (LPO; EC 1.11.1.7) is a milk-derived heme oxidoreductase that plays a central role in the innate antimicrobial defense of mammals by catalyzing the H2O2-dependent oxidation of substrates such as thiocyanate. Beyond this phys...
Sinapic Acid Reduces Hypoxia-Induced Cell Damage in Hep-2 Cells by Regulating TRPM2 Channel Activation [0.03%]
芥子酰烟酸抑制缺氧诱导的Hep-2细胞TRPM2通道活化依赖的损伤
Halil İbrahim Altıner,Tarık Yağcı,Ramazan Çınar et al.
Halil İbrahim Altıner et al.
Hypoxia (HPX) is a significant pathological factor that contributes to mitochondrial dysfunction, oxidative stress, inflammation, and calcium dysregulation in laryngeal squamous cell carcinoma (LSCC). The redox-sensitive TRPM2 channel is cr...