Chemoprotective of Nimbolide Against Diethylnitrosamine Induced Hepatic Cancer via Alteration of NF-κB and PI3K/Akt/mTOR Signaling Pathways [0.03%]
雷公藤内酯醇通过调节NF-κB和PI3K/Akt/mTOR信号途径抑制N-亚硝基化合物所致肝癌化学预防作用的研究
Simiao Zhang,Qi Chen,Shiqi Peng et al.
Simiao Zhang et al.
Hepatocellular carcinoma (HCC) is the 5th rank among all types of cancers, the incidence of the HCC increases globally. The current study was scrutinized the chemoprotective effect of nimbolide against dimethylnitrosamine (DEN) induced HCC ...
Polymeric Nanoparticles for Modulating Reactive Oxygen Species in the Periodontitis Microenvironment [0.03%]
用于调节牙周炎微环境中活性氧的聚合物纳米颗粒
Suleiman Ibrahim Mohammad,Asokan Vasudevan,Ghaleb Oriquat et al.
Suleiman Ibrahim Mohammad et al.
Periodontitis is a chronic inflammatory disease, associated with immune reaction between pathogenic bacteria and host. It is characterized by localized reactive oxygen species (ROS) accumulation. Increased ROS accumulation leads to oxidativ...
AMPK Enhances Autophagy and Inhibits Ferroptosis by Upregulating ULK1 to Ameliorate Acute Skeletal Muscle Ischemia-Reperfusion Injury [0.03%]
AMPK通过上调ULK1增强自噬并抑制铁死亡以改善急性骨骼肌缺血再灌注损伤
Wanghai Li,Jiaoqing Zhou,Jiandong Guo et al.
Wanghai Li et al.
Skeletal muscle ischemia-reperfusion (I/R) injury is a critical clinical condition. AMP-activated protein kinase (AMPK) during IR injury remains unclear. A hindlimb I/R model was established in Sprague-Dawley rats using vascular occlusion. ...
Ergothioneine Ameliorates Alcoholic Fatty Liver Disease: A Dual Strategy of Accelerated Ethanol Elimination and Reducing Oxidative Stress [0.03%]
麦角硫因通过加速酒精消除和降低氧化应激改善酒精性脂肪肝病：一种双重策略
Wei Ding,Juan Cao,Cong Guo et al.
Wei Ding et al.
Alcoholic fatty liver disease (AFLD) is a progressive hepatic pathology triggered by chronic ethanol consumption, serving as the initial stage of severe liver injury. Currently, there are no Food and Drug Administration (FDA)-approved pharm...
LncRNA DLEU1 Regulates TNRC6A Expression to Exacerbate Acute Myocardial Infarction by Adsorbing miR-23a-3p [0.03%]
长链非编码RNA DLEU1通过吸附miR-23a-3p来调控TNRC6A表达从而加重急性心肌梗死
Lushuang Huang,Fei Chai,Nina Chen et al.
Lushuang Huang et al.
Hypoxia-treated H9c2 cells were used to create an in vitro cells injury model. RT-qPCR analysis revealed DLEU1, miR-23a-3p, and TNRC6A expressions in serum of AMI patients and H9c2 cells. The viability and apoptosis of cardiomyocytes were a...
AKT2 Counteracts Hypoxia-Induced Suppression of Homologous Recombination in Triple-Negative Breast Cancer: A Targeted Approach to Sensitize Tumors to PARP Inhibition [0.03%]
Akt2通过对抗缺氧介导的同源重组抑制来诱导三阴性乳腺癌耐药：一种使肿瘤对PARP抑制剂敏感的靶向策略
Ying Liang,Deyu Kong,Yi Zhang et al.
Ying Liang et al.
Triple-negative breast cancer (TNBC) is characterized by hypoxia and impaired fidelity to DNA repair and the activation of survival pathways. However, the role of specific AKT isoforms, particularly AKT2, in regulating residual homologous r...
NF-κB Signaling Pathway Activation in Aflatoxin B1-Induced Hepatocellular Toxicity: Molecular Crosstalk With Oxidative Stress and IκB Degradation [0.03%]
黄曲霉毒素B1诱导肝细胞毒性中NF-κB信号通路活化的分子交叉对话：与氧化应激和IκB降解的相互作用
Salman Hosawi
Salman Hosawi
The highly hepatotoxic and carcinogenic Aspergillus-derived mycotoxin aflatoxin B1 (AFB1) stimulates hepatotoxicity and hepatocarcinogenesis by activating the nuclear factor-κB (NF-κB) signaling pathway. This review summarizes the existin...
Quercetin Attenuates Cytokine Storm in Viral Pneumonia via Inhibition of the TLR3-NF-κB-IL-6 Signaling Axis [0.03%]
檞皮素通过抑制TLR3-NF-κB-IL-6信号轴减轻病毒性肺炎的细胞因子风暴
Yiqun Zhou,Yu Chen,Yanping Shen et al.
Yiqun Zhou et al.
Cytokine storm is a critical determinant of mortality in viral pneumonia. The TLR3-NF-κB signaling pathway mediates excessive inflammatory responses, with IL-6 as a key effector molecule. This study aimed to identify natural compounds capa...
Ginsenoside Rh2 Alleviates Alzheimer Disease Models via Effects on Ferroptosis-Related Neuroinflammation [0.03%]
绞股蓝皂苷Rh2通过影响铁死亡相关神经炎症缓解阿尔茨海默病模型
Qingfu Meng,Jianning Li,Gaungxu Xu et al.
Qingfu Meng et al.
Ginsenosides are the primary active constituents derived from the dried roots of ginseng, a staple in traditional Chinese medicine. This study aimed to evaluate the therapeutic efficacy of the Ginsenoside Rh2 (Rh2) monomer in both in vitro ...
Promising Synthetic Antioxidants of Dimethyltin(IV) Formulations Derived From 4-Acylated Edaravone: Design, DFT Assisted Optimized Molecular Structure and Mechanistic Insights into SET Versus HAT Pathways for Antioxidant Activity [0.03%]
基于4-酰基化edaravone的四甲基锡（IV）制剂的有前景的合成抗氧化剂的设计，DFT辅助优化分子结构以及SET与HAT途径抗氧化活性机制研究
Anita Kumawat,Komal Soni,Sanjiv Saxena et al.
Anita Kumawat et al.
Generation of some new complexes of dimethyltin(IV) of sterically congested 4-acylated amphiphilic edaravone having the general formula Me2SnLL' and Me2Sn(L')2 (where LH= , R = ─CH3, L(1)H; R = ─CH2CH3, L(2)H; R = ─C6H5, L(3)H; R = p-ClC...