BRD4 Aggravates Acute Lung Injury by Inducing Ferroptosis in Alveolar Epithelial Cells [0.03%]
BRD4通过诱导肺泡上皮细胞铁死亡加重急性肺损伤
Xiuli Liu,Ying Gu,Fang Yuan
Xiuli Liu
To investigate the mechanism by which BRD4 accelerates acute lung injury (ALI) by promoting ferroptosis mediated by ANP32B/H3K27ac/MYC/HOXB8/BACH1 in alveolar epithelial cells. Gene co-expression was analyzed with bioinformatics. Eighteen S...
Sleep Deprivation Inhibits CD8+ T Cell Function by Elevating Galectin-9 Expression in Colorectal Cancer Cells [0.03%]
睡眠剥夺通过提高结直肠癌细胞半乳糖凝集素-9的表达抑制CD8+t细胞功能
Li Siwei,Pi Guoliang,Wang Jinglong et al.
Li Siwei et al.
Sleep disturbance is thought to impair immune regulation and reduce the effectiveness of cancer immunotherapies such as immune checkpoint blockade, but the mechanisms in colorectal cancer are not well defined. This study investigated how re...
Protective Effect of Gigantol Against Streptozotocin-Induced Gestational Diabetes Mellitus via Modulation of the Nrf2/HO-1, TLR4/MyD88/NF-κB, and PI3K/Akt/GSK-3β Signaling Pathways [0.03%]
甘遂醇通过调节Nrf2/HO-1、TLR4/MyD88/NF-κB和PI3K/Akt/GSK-3β信号通路对链脲佐菌素诱导的妊娠糖尿病 mellitus 的保护作用
Yeqing Su,Jiejie Xing,Xian Zheng
Yeqing Su
Gestational diabetes mellitus (GDM) is a chronic metabolic disease occur during the pregnancy which is characterized via insulin resistance, hyperglycemia, inflammation and oxidative stress. Gigantol, a naturally occurring bibenzyl phytocon...
Unraveling the Potential of Empagliflozin to Counteract 1,2-Dimethylhydrazine-Induced Colorectal Cancer in Rats: Involvement of Redox Imbalance, Inflammatory Cascades, and Unprogrammed Cell Proliferation [0.03%]
恩格列净解除1,2-二甲基肼诱导的大鼠结直肠癌的潜在机制：涉及氧化应激，炎症级联和非程序性细胞增殖
Hager Abd Al-Hamid,Mohamed O Mahmoud,Mona R El-Ansary et al.
Hager Abd Al-Hamid et al.
Globally, colorectal cancer ranks second in terms of mortality and is the third most frequent cancer. This study was designed to evaluate empagliflozin ability to suppress the progression of 1,2-dimethylhydrazine (DMH)-induced colorectal ca...
Punicalagin Inhibits the Growth and Proliferation of Ovarian Epithelial Adenocarcinoma Cells Via Apoptosis and Autophagic Cell Death [0.03%]
番石榴素通过凋亡和自噬依赖性细胞死亡抑制卵巢上皮腺癌细胞的生长和增殖
Zeeshan Ahmad Bhutta,Cho-Won Kim,Hwayoung Na et al.
Zeeshan Ahmad Bhutta et al.
Ovarian cancer remains a leading cause of gynecologic cancer-related mortality and is frequently associated with therapeutic resistance. Punicalagin (PCG), a pomegranate-derived polyphenol, has demonstrated anticancer activity in multiple t...
Lyoniresinol Attenuates Cobalt-Induced Neurobehavioral Deficits and Inflammatory Responses Associated With NF-κB/GSK3β/JNK Signaling in Rats [0.03%]
lyoniresinol通过NF-κB/GSK3β/JNK信号通路减轻钴致大鼠神经行为缺损及炎症反应
Yuming Zhang,Jun Wang,Qifan Huo et al.
Yuming Zhang et al.
Cobalt exposure, increasingly encountered in industrial and medical contexts, represents a rising neurotoxic threat, yet its underlying mechanisms and effective treatments remain poorly characterized. Here, we investigated the neuroprotecti...
Comparative Efficacy of Quercetin, Catechin and Genistein in Restoring Hepatic Thiols Homeostasis and Histopathological Alterations in Cisplatin-Induced Acute Hepatotoxicity [0.03%]
檞皮素、儿茶素和染料木素在恢复顺铂诱导的急性肝毒性大鼠肝脏硫醇稳态失衡及组织病理损伤方面的疗效比较研究
Pawan K Verma,Priyanka Sharma,Bhawani Singh et al.
Pawan K Verma et al.
The study aimed to determine the efficacy of quercetin, catechin and genistein in restoring plasma hepatic biomarkers, oxidative indices and histopathological alterations in the liver following cisplatin (cDDP) exposure in Wistar rats. Admi...
Comparison of Rapamycin and 3-Methyladenine in Cisplatin-Induced Experimental Cardiotoxicity [0.03%]
雷帕霉素和3-甲基腺嘌呤对顺铂诱导的心肌损伤的比较研究
Derya Karabulut,Emin Kaymak,Emel Öztürk et al.
Derya Karabulut et al.
In this study, we evaluated how cisplatin cardiotoxicity affects the histological and endocrine functions of the heart and autophagy while using Rapamycin(Rapa) and 3-methyladenine(3-MA) as autophagy activators and inhibitors. Control, Cisp...
Heba Ibrahim Abd El-Moaty,Ahmed S Doghish,Ahmed I Abulsoud et al.
Heba Ibrahim Abd El-Moaty et al.
Kaposi sarcoma (KS) is a vascular malignancy caused by human herpesvirus 8 (HHV-8), also known as Kaposi sarcoma-associated herpesvirus (KSHV). Clinically, KS presents with characteristic lesions on the skin or mucosal surfaces and may exte...
Escin Attenuates Amyloid Beta 1-42-Induced Oxidative Stress, Apoptosis, and Neuroinflammation in Neuron-Like SH-SY5Y Cells [0.03%]
escin通过减轻氧化应激、凋亡和促炎细胞因子的产生来预防淀粉样β蛋白（Aβ1-42）诱导的神经毒性作用
Sakine Akar,Ozge Alvur,Gulsah Evyapan et al.
Sakine Akar et al.
The pathogenesis of Alzheimer's disease (AD) involves amyloid beta (Aβ)-induced oxidative stress, apoptotic cell death, and neuroinflammation, contributing to neuronal dysfunction. In our study, a differentiation protocol using retinoic ac...