The IGF1-PGM5 Axis Inhibits Aerobic Glycolysis and Serves As a Tumor Suppressor in Nasopharyngeal Carcinoma [0.03%]
IGF1-PGM5轴抑制鼻咽癌的糖酵解并发挥抑癌作用
Xiaolin Ji,Lin Li,Jingyuan Wang et al.
Xiaolin Ji et al.
Nasopharyngeal carcinoma (NPC) is a prevalent malignancy with a distinct geographical distribution. This study aimed to identify core glycolysis-related genes and investigate their functional roles in NPC pathogenesis. Integrated transcript...
Exploring Novel Compounds and Nanocomplexes to Target Cellular and Molecular Interactions in the Glioblastoma Microenvironment [0.03%]
探索新颖化合物和纳米复合物以靶向胶质母细胞瘤微环境中的细胞和分子相互作用
Ghaleb Oriquat,Amr Ali Mohamed Abdelgawwad El-Sehrawy,Bahjat Alhasso et al.
Ghaleb Oriquat et al.
Glioblastoma is the most lethal primary brain tumor, characterized by a profoundly immunosuppressive microenvironment. This stroma includes various immunosuppressive and tumor-killing cells. This review critically evaluates emerging strateg...
Perspectives in Nanotoxicity Studies for Carbon-Based Nanomaterials in 3D Platform [0.03%]
基于碳纳米材料三维平台的纳米毒理学研究展望
Ayimgül Uzunyol,Fatih Inci
Ayimgül Uzunyol
The conventional two-dimensional (2D) in vitro cell culture system has been a staple in biological research for decades. However, due to numerous limitations, this strategy is being replaced by 3D cell culture, representing a significant ad...
Synthesis of Dihydrothiophene Ureidoformamide Derivatives and Exploration of Their Potential Anticancer Activity [0.03%]
二氢噻吩脲基甲酰胺衍生物的合成及其潜在抗肿瘤活性的研究
Khawla Boudebbous,Arif Mermer,Tuğba Kul Köprülü et al.
Khawla Boudebbous et al.
Dihydrothiophene ureidoformamide derivatives are sulfur-containing heterocyclic frameworks that remain relatively underexplored for their anticancer potential, despite possessing structural features that may enable interactions with biologi...
MAPK12 Upregulates PD-L1 Expression in Hepatocellular Carcinoma to Induce Immune Suppression Through the PI3K/AKT/mTOR Pathway [0.03%]
MAPK12通过PI3K/Akt/mTOR信号通路上调肝癌细胞PD-L1表达诱导免疫抑制
Qian Zhang,Jun-Jie Li,Jin-Hai Wang et al.
Qian Zhang et al.
This study sought to investigate the impact of MAPK12 on immune evasion in hepatocellular carcinoma (HCC) by modulating PD-L1 expression through the PI3K/AKT/mTOR pathway. Using GEPIA, Kaplan-Meier plotter, and TIMER databases, MAPK12 expre...
MiR-30a-5p Suppresses the ERK Signaling Pathway by Targeting Vimentin to Inhibit the Migration and Epithelial-Mesenchymal Transition of Colorectal Cancer Cells [0.03%]
MiR-30a-5p通过靶向波形蛋白抑制ERK信号通路从而抑制结直肠癌细胞迁移及上皮间质转化
Fei Tu,Fengyuan He,Yiqiu Zhang et al.
Fei Tu et al.
MicroRNAs regulate development, progression, and metastasis in colorectal cancer (CRC). Although miR-30a-5p participates in the pathogenesis of various malignancies, detailed molecular mechanisms in CRC remain largely uncharacterized. By an...
Vinpocetine Attenuates Hepatic Steatosis by Modulating Key Lipogenic and Lipid Transport Genes (PPAR- γ, SREBP, and FAT/CD36) in Experimental Non-Alcoholic Fatty Liver Disease [0.03%]
长春西汀通过调节关键生脂和脂质转运基因（过氧化物酶体增殖激活受体γ、固醇调节元件结合蛋白和脂肪细胞分化相关抗原）来缓解实验性非酒精性脂肪肝病中的肝脏脂变性
Ekram N Abdalhaleem,Bashir A Yousef
Ekram N Abdalhaleem
Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder characterized by excessive lipid accumulation in hepatocytes and is strongly associated with obesity, insulin resistance, and dyslipidaemia. Targeting key regulators o...
METTL3 Promotes Castration-Resistant Prostate Cancer Progression by Enhancing AKR1C3 Expression [0.03%]
METTL3通过增强AKR1C3表达促进去势抵抗性前列腺癌进展
Qihong Nie,Xiaoyuan Wu,Xin Huang et al.
Qihong Nie et al.
Castration-resistant prostate cancer (CRPC) is a lethal stage of prostate cancer (PC). This research sought to examine the functions and underlying mechanisms of N6-methyladenosine (m6A) methyltransferases in CRPC. Transcriptomic datasets f...
Regulation of Endoplasmic Reticulum Stress Suppresses Early Pro-Tumorigenic Events During N-Nitrosodiethylamine-Induced Hepatocarcinogenesis [0.03%]
内质网应激的调节可抑制N-亚硝基二乙胺致肝癌过程中的早期原肿瘤事件
Maya P Shetty,Smita Hegde,Sanjay Bharati
Maya P Shetty
Carcinogenesis is a dynamic, multistep process in which the initiation stage represents a critical and irreversible event that determines cellular fate. Although genetic alterations play a central role in tumor development, dysregulation of...
Robinin Attenuates Xenobiotic Enzymes, Inflammation, and Apoptosis on DMH-Induced Colon Cancer via Modulating Ras/PI3K/Akt/mTOR and NF-κB/Bax/Caspase-3 Signalling Pathways in Wistar Rats [0.03%]
robinin通过调节Wistar大鼠Ras/PI3K/Akt/mTOR和NF-κB/Bax/Caspase-3信号通路对DMH诱导的结肠癌的作用研究
Wang Anlei,Wang Kaihao,Gong Yazhao et al.
Wang Anlei et al.
With a high death rate, colorectal cancer (CRC) is the third most frequent cancer worldwide. Despite advances in medical therapeutics, effective treatments for CRC remain a significant challenge. Understanding the fundamental molecular mech...